Enhancement of Peroxynitrite-Induced Apoptosis in PC12 Cells by Fibroblast Growth Factor-1 and Nerve Growth Factor Requires p21Ras Activation and Is Suppressed by Bcl-2

Exploratory Data Analysis

1977 • 12,265 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.

1995 • 1,968 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide.

1985 • 1,068 citations

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

1996 • 771 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

1996 • 341 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Transducing signals of life and death

1997 • 275 citations

Induction of nitrotyrosine-like immunoreactivity in the lower motor neuron of amyotrophic lateral sclerosis

1995 • 266 citations

Sensitivity of the Essential Zinc-Thiolate Moiety of Yeast Alcohol Dehydrogenase to Hypochlorite and Peroxynitrite

1995 • 246 citations

The Protooncogene bcl‐2 Inhibits Apoptosis in PC12 Cells

1993 • 222 citations

Colocalization of NOS and SOD1 in neurofilament accumulation within motor neurons of amyotrophic lateral sclerosis: an immunohistochemical study

1996 • 157 citations

Peroxynitrite Causes Apoptosis in Rat Thymocytes

1995 • 153 citations

Phosphorylation of Bcl-2 Protein and Association with p21Ras in Ras-induced Apoptosis

1996 • 132 citations

Ras controls coupling of growth factor receptors and protein kinase C in the membrane to Raf-1 and B-Raf protein serine kinases in the cytosol.

1992 • 111 citations

The apoptosis endonuclease and its regulation.

1992 • 108 citations

Nerve growth factor induces rapid accumulation of the GTP-bound form of p21ras in rat pheochromocytoma PC12 cells.

1992 • 98 citations

p53 modulation of anchorage independent growth and experimental metastasis.

1996 • 80 citations

Nerve Growth Factor Protects PC12 Cells Against Peroxynitrite‐Induced Apoptosis via a Mechanism Dependent on Phosphatidylinositol 3‐Kinase

1997 • 75 citations

Release from G1 growth arrest by transforming growth factor beta 1 requires cellular ras activity.

1993 • 69 citations

Acidic Fibroblast Growth Factor Enhances Peroxynitrite-Induced Apoptosis in Primary Murine Fibroblasts

1996 • 44 citations

Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2.

1995 • 36 citations

Early changes in protein synthesis induced by basic fibroblast growth factor, nerve growth factor, and epidermal growth factor in PC12 pheochromocytoma cells.

1994 • 32 citations