Phosphatidylinositol 3′-Kinase-independent p70 S6 Kinase Activation by Fibroblast Growth Factor Receptor-1 Is Important for Proliferation but Not Differentiation of Endothelial Cells

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

Molecular mechanisms of angiogenesis: fibroblast growth factor signal transduction

1995 • 461 citations

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

1991 • 443 citations

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity

1992 • 441 citations

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

1995 • 441 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Point mutation of an FGF receptor abolishes phosphatidylinositol turnover and Ca2+ flux but not mitogenesis

1992 • 414 citations

Phosphatidylinositol 3-Kinase Is an Early Intermediate in the Gβγ-mediated Mitogen-activated Protein Kinase Signaling Pathway

1996 • 372 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

When is a lipid kinase not a lipid kinase? When it is a protein kinase

1995 • 315 citations

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1994 • 303 citations

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

1995 • 298 citations

The 70 kDa S6 Kinase Complexes with and Is Activated by the Rho Family G Proteins Cdc42 and Rac1

1996 • 293 citations

Wortmannin and Its Structural Analogue Demethoxyviridin Inhibit Stimulated Phospholipase A2 Activity in Swiss 3T3 Cells

1995 • 252 citations

The Principal Rapamycin-Sensitive p70^s6k Phosphorylation Sites, T-229 and T-389, Are Differentially Regulated by Rapamycin-Insensitive Kinase Kinases

1996 • 245 citations

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

1995 • 243 citations

An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

1992 • 242 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

Multiple Independent Inputs Are Required for Activation of the p70 S6 Kinase

1995 • 234 citations

Identification and characterization of a mitogen-activated S6 kinase.

1988 • 223 citations

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

1995 • 208 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras

1994 • 207 citations

p70 S6 kinase: an enigma with variations

1996 • 202 citations

Nuclear localization of p85s6k: functional requirement for entry into S phase.

1994 • 202 citations

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.

1991 • 182 citations

Rapamycin, Wortmannin, and the Methylxanthine SQ20006 Inactivate p70s6k by Inducing Dephosphorylation of the Same Subset of Sites

1995 • 168 citations

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs.

1992 • 166 citations

EGF induces biphasic S6 kinase activation: Late phase is protein kinase C-dependent and contributes to mitogenicity

1989 • 122 citations

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.

1992 • 119 citations

Fibroblast growth factor receptor 1-induced differentiation of endothelial cell line established from tsA58 large T transgenic mice.

1996 • 119 citations

Diverse receptors for fibroblast growth factors

1992 • 119 citations

FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.

1995 • 116 citations

Shc and a Novel 89-kDa Component Couple to the Grb2-Sos Complex in Fibroblast Growth Factor-2-stimulated Cells

1995 • 114 citations

Rapamycin-FKBP12 blocks proliferation, induces differentiation, and inhibits cdc2 kinase activity in a myogenic cell line.

1993 • 105 citations

The Rapamycin and FKBP12 Target (RAFT) Displays Phosphatidylinositol 4-Kinase Activity

1995 • 85 citations

Phosphatidylinositol 3-OH Kinase Activity Is Not Required for Activation of Mitogen-activated Protein Kinase by Cytokines

1996 • 57 citations

Normal Activation of P70 S6 Kinase by Insulin in Cells Overexpressing Dominant Negative 85-kDa Subunit of Phosphoinositide 3-Kinase

1995 • 45 citations

Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin.

1992 • 44 citations

cDNA Cloning and Expression of a Human FGF Receptor which Binds Acidic and Basic FGF

1991 • 38 citations