T‐ and B‐cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis

Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination

2000 • 3,258 citations

Identification of autoantibodies associated with myelin damage in multiple sclerosis

1999 • 881 citations

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

1996 • 741 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H‐2^b mice: Fine specificity and T cell receptor Vβ expression of encephalitogenic T cells

1995 • 600 citations

Autoimmunity to Myelin Oligodendrocyte Glycoprotein in Rats Mimics the Spectrum of Multiple Sclerosis Pathology

1998 • 524 citations

IL-6-Deficient Mice Are Resistant to Experimental Autoimmune Encephalomyelitis: Roles of IL-6 in the Activation and Differentiation of Autoreactive T Cells

1998 • 448 citations

Multiple sclerosis: In situ evidence for antibody‐ and complement‐mediated demyelination

1998 • 423 citations

Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells

2000 • 399 citations

Differential Ultrastructural Localization of Myelin Basic Protein, Myelin/Oligodendroglial Glycoprotein, and 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase in the CNS of Adult Rats

1989 • 388 citations

Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice.

1994 • 384 citations

A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease.

1987 • 368 citations

Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectives

1997 • 365 citations

Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study

1999 • 345 citations

Uncoupling the Proinflammatory from the Immunosuppressive Properties of Tumor Necrosis Factor (Tnf) at the P55 TNF Receptor Level

2001 • 334 citations

Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.

1993 • 319 citations

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

1996 • 319 citations

A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody

1984 • 318 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate.

1995 • 314 citations

IL-6-deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis

1998 • 307 citations

B cells are critical to induction of experimental allergic encephalomyelitis by protein but not by a short encephalitogenic peptide

1999 • 290 citations

Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: A case for antigen-specific antibody mediation

1999 • 289 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 284 citations

Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis

1997 • 267 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

MHC haplotype-dependent regulation of MOG-induced EAE in rats.

1998 • 257 citations

IFN-gamma is critical to the control of murine autoimmune encephalomyelitis and regulates both in the periphery and in the target tissue: a possible role for nitric oxide.

1999 • 246 citations

Vesicular removal by oligodendrocytes of membrane attack complexes formed by activated complement

1989 • 243 citations

B Lymphocytes Producing Demyelinating Autoantibodies: Development and Function in Gene-targeted Transgenic Mice

1998 • 241 citations

Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily

1992 • 240 citations

Human Nerve Growth Factor Protects Common Marmosets against Autoimmune Encephalomyelitis by Switching the Balance of T Helper Cell Type 1 and 2 Cytokines within the Central Nervous System

2000 • 233 citations

The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat

1995 • 231 citations

IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligodendrocyte glycoprotein

1998 • 229 citations

Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex.

1993 • 221 citations

Antibody responses in chronic relapsing experimental allergic encephalomyelitis: correlation of serum demyelinating activity with antibody titre to the myelin/oligodendrocyte glycoprotein (MOG)

1987 • 217 citations

B-cell-deficient mice develop experimental allergic encephalomyelitis with demyelination after myelin oligodendrocyte glycoprotein sensitization.

1998 • 208 citations

Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions

1988 • 206 citations

IFN-γ Is Critical to the Control of Murine Autoimmune Encephalomyelitis and Regulates Both in the Periphery and in the Target Tissue: A Possible Role for Nitric Oxide

1999 • 204 citations

Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1

1999 • 201 citations

Soluble recombinant complement receptor 1 inhibits inflammation and demyelination in antibody-mediated demyelinating experimental allergic encephalomyelitis.

1994 • 201 citations

Antibodies to myelin-oligodendrocyte glycoprotein in cerebrospinal fluid from patients with multiple sclerosis and controls

1991 • 196 citations

Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia.

1994 • 186 citations

Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis.

1995 • 185 citations

Cutting Edge: B Cell-Deficient Mice Develop Experimental Allergic Encephalomyelitis with Demyelination After Myelin Oligodendrocyte Glycoprotein Sensitization

1998 • 177 citations

Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: Reactivity to the extracellular domain of MOG is directed against three main regions

1997 • 169 citations

Chronic relapsing experimental autoimmune encephalomyelitis with a delayed onset and an atypical clinical course, induced in PL/J mice by myelin oligodendrocyte glycoprotein (MOG)‐derived peptide: Preliminary analysis of MOG T cell epitopes

1995 • 157 citations

THE ROLE OF COMPLEMENT IN THE PATHOGENESIS OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

1989 • 156 citations

Multiple sclerosis: B- and T-cell responses to the extracellular domain of the myelin oligodendrocyte glycoprotein

1999 • 152 citations

Butyrophilin, a Milk Protein, Modulates the Encephalitogenic T Cell Response to Myelin Oligodendrocyte Glycoprotein in Experimental Autoimmune Encephalomyelitis

2000 • 151 citations

The M2 autoantigen of central nervous system myelin, a glycoprotein present in oligodendrocyte membrane.

1986 • 151 citations

Myelin Oligodendrocyte Glycoprotein Induces Experimental Autoimmune Encephalomyelitis in the “Resistant” Brown Norway Rat: Disease Susceptibility Is Determined by MHC and MHC-Linked Effects on the B Cell Response

1999 • 144 citations

Active and passively induced experimental autoimmune encephalomyelitis in common marmosets: A new model for multiple sclerosis

1995 • 136 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 136 citations

Myelin/Oligodendrocyte Glycoprotein-Induced Autoimmune Encephalomyelitis in Common Marmosets: The Encephalitogenic T Cell Epitope pMOG24–36 Is Presented by a Monomorphic MHC Class II Molecule

2000 • 116 citations

Increased reactivity to myelin oligodendrocyte glycoprotein peptides and epitope mapping in HLA DR2(15)+ multiple sclerosis

1998 • 116 citations

The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls

2001 • 115 citations

Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG)

1999 • 114 citations

A new primate model for multiple sclerosis in the common marmoset

2000 • 112 citations

Structure and evolution of the extended B7 family

1999 • 107 citations

Myelin oligodendrocyte glycoprotein‐induced autoimmune encephalomyelitis is chronic/relapsing in perforin knockout mice, but monophasic in Fas‐ and Fas ligand‐deficient lpr and gld mice

1997 • 101 citations

In healthy primates, circulating autoreactive T cells mediate autoimmune disease.

1994 • 99 citations

Elevated Levels of Antibody to Myelin Oligodendrocyte Glycoprotein Is Not Specific for Patients With Multiple Sclerosis

1999 • 98 citations

Central Nervous System-Targeted Expression of the Complement Inhibitor sCrry Prevents Experimental Allergic Encephalomyelitis

1999 • 93 citations

Antibody-mediated demyelination in experimental allergic encephalomyelitis is independent of complement membrane attack complex formation

1991 • 86 citations

Antibody Association with a Novel Model for Primary Progressive Multiple Sclerosis: Induction of Relapsing‐Remitting and Progressive Forms of EAE in H2^S Mouse Strains

2000 • 85 citations

Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern

1998 • 80 citations

Investigation of Myelin/Oligodendrocyte Glycoprotein Membrane Topology

1996 • 77 citations

BTL-II : a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse

2000 • 77 citations

A Review of the Molecular and Cellular Biology of Butyrophilin, the Major Protein of Bovine Milk Fat Globule Membrane

1993 • 74 citations

Antibodies to Myelin/Oligodendrocyte‐Specific Protein and Myelin/Oligodendrocyte Glycoprotein Signal Distinct Changes in the Organization of Cultured Oligodendroglial Membrane Sheets

1994 • 74 citations

Screening of several H-2 congenic mouse strains identified H-2q mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement

2000 • 73 citations

The central nervous sytem-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS)

2000 • 71 citations

Autoreactivity to myelin antigens: myelin/oligodendrocyte glycoprotein is a prevalent autoantigen

1999 • 68 citations

Linkage Analysis of Myelin Oligodendrocyte Glycoprotein-Induced Experimental Autoimmune Encephalomyelitis in the Rat Identifies a Locus Controlling Demyelination on Chromosome 18

1999 • 67 citations

Interferon‐γ potentiates antibody‐mediated demyelination in vivo

1992 • 65 citations

Rhesus monkeys are highly susceptible to experimental autoimmune encephalomyelitis induced by myelin oligodendrocyte glycoprotein: characterisation of immunodominant T- and B-cell epitopes

2000 • 63 citations

Induction of EAE in mice with recombinant human MOG, and treatment of EAE with a MOG peptide

1997 • 62 citations

Susceptibility and Resistance to Experimental Allergic Encephalomyelitis: Relationship with Hypothalamic-Pituitary-Adrenocortical Axis Responsiveness in the Rat²

1999 • 53 citations

Myelin oligodendrocyte glycoprotein-DNA vaccination induces antibody-mediated autoaggression in experimental autoimmune encephalomyelitis

2000 • 52 citations

Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55.

1996 • 47 citations

Demyelinating Antibodies to Myelin Oligodendrocyte Glycoprotein and Galactocerebroside Induce Degradation of Myelin Basic Protein in Isolated Human Myelin

1997 • 47 citations

Encephalitogenic and neuritogenic T cell responses to the myelin-associated glycoprotein (MAG) in the Lewis rat

1999 • 46 citations

Inhibition of Complement as a Therapeutic Approach in Inflammatory Central Nervous System (CNS) Disease

1999 • 44 citations

Physical mapping of the human and mouse MOG gene at the distal end of the MHC class Ib region

1995 • 44 citations

Membrane topology of the myelin/oligodendrocyte glycoprotein

1998 • 41 citations

The immunopathology of chronic experimental allergic encephalomyelitis induced in rabbits with bovine proteolipid protein.

1986 • 40 citations

Genetics of rat neuroinflammation

2000 • 35 citations

Development of Myelin Oligodendrocyte Glycoprotein Autoreactive Transgenic B Lymphocytes: Receptor Editing In Vivo After Encounter of a Self-Antigen Distinct from Myelin Oligodendrocyte Glycoprotein

2000 • 34 citations

Mapping of H2-M homolog and MOG genes in the rat MHC

1995 • 29 citations

High‐Dose Soluble Antigen: Peripheral T‐Cell Proliferation or Apoptosis

1994 • 28 citations

Autoimmune Demyelination in the Central Nervous Systema

1988 • 27 citations

Susceptibility and Resistance to Experimental Allergic Encephalomyelitis: Relationship with Hypothalamic-Pituitary-Adrenocortical Axis Responsiveness in the Rat

1999 • 23 citations

Transgenic Models of Tnf Induced Demyelination

1999 • 19 citations

Cloning, expression analysis, and chromosomal localization of a novel butyrophilin-like receptor

1999 • 10 citations