A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System

1996 • 903 citations

Following a diabetogenic T cell from genesis through pathogenesis

1993 • 708 citations

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

1993 • 688 citations

A full genome search in multiple sclerosis

1996 • 666 citations

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

1996 • 650 citations

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

1996 • 638 citations

A genetic basis for familial aggregation in multiple sclerosis

1995 • 626 citations

A Critical Evaluation

1964 • 577 citations

HLA class II-associated genetic susceptibility in multiple sclerosis: A critical evaluation

1991 • 487 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

Genomewide Scan of Multiple Sclerosis in Finnish Multiplex Families

1997 • 308 citations

Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis

1998 • 299 citations

Crystal Structure of HLA-DR2 (DRA*0101, DRB1*1501) Complexed with a Peptide from Human Myelin Basic Protein

1998 • 288 citations

Linkage of the MHC to familial multiple sclerosis suggests genetic heterogeneity. The Multiple Sclerosis Genetics Group

1998 • 284 citations

Progress in determining the causes and treatment of multiple sclerosis

1999 • 280 citations

Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide.

1994 • 237 citations

Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

1993 • 201 citations

Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis

1995 • 181 citations

Cassette vectors directing expression of T cell receptor genes in transgenic mice

1995 • 159 citations

CD4+ T Cells Prevent Spontaneous Experimental Autoimmune Encephalomyelitis in Anti–Myelin Basic Protein T Cell Receptor Transgenic Mice

1998 • 159 citations

The multiple sclerosis‐ and narcolepsy‐associated HLA class II haplotype includes the DRB5*0101 allele

1995 • 129 citations

Specificity of an HLA‐DRB1*0401‐restricted T cell response to type II collagen

1996 • 115 citations

Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response.

1994 • 90 citations

A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice

1993 • 87 citations

Induction of Apoptosis and T Helper 2 (Th2) Responses Correlates with Peptide Affinity for the Major Histocompatibility Complex in Self-reactive T Cell Receptor Transgenic Mice

1997 • 75 citations

Genetics of Multiple Sclerosis

1998 • 74 citations

Chronic experimental autoimmune encephalomyelitis induced by the 89‐101 myelin basic protein peptide in B10RIII (H2^r) mice

1991 • 63 citations

HLA typing in the United Kingdom multiple sclerosis genome screen

1998 • 58 citations

Tolerance and autoimmunity in TCR transgenic mice specific for myelin basic protein

1999 • 44 citations

The HLA‐DQ(α1*0102, β1*0602) heterodimer may confer susceptibility to multiple sclerosis in the absence of the HLA‐DR(α1*01, β1*1501) heterodimer

1997 • 37 citations

Inheritance of susceptibility to multiple sclerosis

1998 • 17 citations