Recognition of viruses by innate immunity

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Gout-associated uric acid crystals activate the NALP3 inflammasome

2006 • 4,851 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

2004 • 3,745 citations

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 • 3,607 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

2005 • 3,059 citations

Cryopyrin activates the inflammasome in response to toxins and ATP

2006 • 2,874 citations

IKKε and TBK1 are essential components of the IRF3 signaling pathway

2003 • 2,536 citations

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 • 2,449 citations

Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway

2002 • 2,438 citations

5'-Triphosphate RNA Is the Ligand for RIG-I

2006 • 2,329 citations

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 • 2,312 citations

RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

2006 • 2,116 citations

IRF-7 is the master regulator of type-I interferon-dependent immune responses

2005 • 2,108 citations

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

2005 • 1,761 citations

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

2003 • 1,625 citations

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

2005 • 1,602 citations

Cell Type-Specific Involvement of RIG-I in Antiviral Response

2005 • 1,311 citations

Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

2006 • 1,292 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

2003 • 1,226 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

2003 • 1,189 citations

Intracellular pattern recognition receptors in the host response

2006 • 1,170 citations

Type I Interferons in Host Defense

2006 • 1,155 citations

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

2006 • 1,130 citations

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

2004 • 1,109 citations

Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

2006 • 1,099 citations

Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF

2005 • 1,062 citations

Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

2004 • 994 citations

NOD-LRR PROTEINS: Role in Host-Microbial Interactions and Inflammatory Disease

2005 • 970 citations

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN -β promoter

2004 • 947 citations

Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1

2006 • 947 citations

Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases

2006 • 926 citations

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6

2005 • 915 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction

2005 • 886 citations

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

2005 • 847 citations

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

2002 • 844 citations

Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells

2007 • 829 citations

RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation

2004 • 821 citations

Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

2005 • 799 citations

GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large

2006 • 775 citations

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

2005 • 755 citations

Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency

2006 • 721 citations

The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9

2006 • 704 citations

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

2006 • 700 citations

Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling

2003 • 692 citations

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9

2003 • 690 citations

Critical Role for Cryopyrin/Nalp3 in Activation of Caspase-1 in Response to Viral Infection and Double-stranded RNA

2006 • 681 citations

A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region

2006 • 677 citations

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

2002 • 619 citations

The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I

2005 • 602 citations

The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses

2006 • 588 citations

The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection

2004 • 563 citations

NF-kappa B activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

1999 • 554 citations

IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts

2003 • 524 citations

Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

2004 • 520 citations

Detrimental Contribution of the Toll-Like Receptor (TLR)3 to Influenza A Virus–Induced Acute Pneumonia

2006 • 487 citations

Essential role of IPS-1 in innate immune responses against RNA viruses

2006 • 483 citations

Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction

2005 • 468 citations

A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling

2000 • 456 citations

Herpes simplex virus type-1 induces IFN-α production via Toll-like receptor 9-dependent and -independent pathways

2004 • 437 citations

Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125

2007 • 429 citations

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

2006 • 411 citations

Loss of DExD/H Box RNA Helicase LGP2 Manifests Disparate Antiviral Responses

2007 • 389 citations

Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection

2004 • 380 citations

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells

2006 • 373 citations

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

2004 • 355 citations

Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence

2005 • 348 citations

Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA

2004 • 347 citations

Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria

2007 • 343 citations

IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9

2006 • 339 citations

Osteopontin expression is essential for interferon-α production by plasmacytoid dendritic cells

2006 • 333 citations

Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity

2007 • 326 citations

Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

2006 • 293 citations

EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN

2006 • 289 citations

A FADD-dependent innate immune mechanism in mammalian cells

2004 • 281 citations

Inhibition of Toll-Like Receptor 7- and 9-Mediated Alpha/Beta Interferon Production in Human Plasmacytoid Dendritic Cells by Respiratory Syncytial Virus and Measles Virus

2005 • 234 citations

Modulation of the Interferon Antiviral Response by the TBK1/IKKi Adaptor Protein TANK

2007 • 212 citations

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK

2007 • 194 citations

Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells

2006 • 189 citations

MDA-5 Is Cleaved in Poliovirus-Infected Cells

2007 • 189 citations

Cutting Edge: Roles of Caspase-8 and Caspase-10 in Innate Immune Responses to Double-Stranded RNA

2006 • 177 citations

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling

2007 • 172 citations

Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors

2007 • 155 citations

NAK-Associated Protein 1 Participates in Both the TLR3 and the Cytoplasmic Pathways in Type I IFN Induction

2006 • 137 citations

Overexpression of Helicard, a CARD-Containing Helicase Cleaved during Apoptosis, Accelerates DNA Degradation

2002 • 137 citations

Interferon‐regulatory‐factor 1 controls Toll‐like receptor 9‐mediated IFN‐β production in myeloid dendritic cells

2007 • 136 citations

Drosophila IKK-Related Kinase Regulates Nonapoptotic Function of Caspases via Degradation of IAPs

2006 • 129 citations

TLR3 Deletion Limits Mortality and Disease Severity due to Phlebovirus Infection

2006 • 126 citations

Autophagy in Innate Immunity against Intracellular Bacteria

2006 • 125 citations

NF‐κB activation through IKK‐i‐dependent I‐TRAF/TANK phosphorylation

2000 • 101 citations

Cutting Edge: Role of TANK-Binding Kinase 1 and Inducible IκB Kinase in IFN Responses against Viruses in Innate Immune Cells

2006 • 86 citations

Differential regulation and role of interleukin-1 receptor associated kinase-M in innate immunity signaling

2007 • 48 citations