Type I Interferons in Host Defense

Pathogen Recognition and Innate Immunity

2006 • 11,197 citations

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Toll-like receptor control of the adaptive immune responses

2004 • 4,092 citations

HOW CELLS RESPOND TO INTERFERONS

1998 • 3,937 citations

Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8

2004 • 3,766 citations

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

2004 • 3,745 citations

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 • 3,607 citations

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 • 3,351 citations

Virus interference. I. The interferon

1957 • 3,331 citations

Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA

2004 • 3,325 citations

Approaching the Asymptote? Evolution and Revolution in Immunology

1989 • 3,079 citations

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

2005 • 3,059 citations

Antiviral Actions of Interferons

2001 • 2,683 citations

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 • 2,449 citations

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 • 2,312 citations

Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

2002 • 2,276 citations

IRF-7 is the master regulator of type-I interferon-dependent immune responses

2005 • 2,108 citations

Innate immune recognition of viral infection

2006 • 1,790 citations

Recognition of single-stranded RNA viruses by Toll-like receptor 7

2004 • 1,777 citations

VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

2005 • 1,761 citations

Plasmacytoid dendritic cells in immunity

2004 • 1,645 citations

Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

2003 • 1,456 citations

Cell Type-Specific Involvement of RIG-I in Antiviral Response

2005 • 1,311 citations

Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

2006 • 1,292 citations

Potent and Selective Stimulation of Memory-Phenotype CD8+ T Cells In Vivo by IL-15

1998 • 1,262 citations

Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling

2002 • 1,228 citations

DNA Deamination Mediates Innate Immunity to Retroviral Infection

2003 • 1,219 citations

Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling

1998 • 1,218 citations

TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction

2003 • 1,203 citations

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

2003 • 1,189 citations

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

2006 • 1,130 citations

Recognition of Cytosolic DNA Activates an IRF3-Dependent Innate Immune Response

2006 • 983 citations

Type I Interferon in Systemic Lupus Erythematosus and Other Autoimmune Diseases

2006 • 926 citations

Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection

2005 • 919 citations

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

2002 • 909 citations

Toll-like receptor 3 promotes cross-priming to virus-infected cells

2005 • 902 citations

Type 1 Interferons and the Virus-Host Relationship: A Lesson in Détente

2006 • 859 citations

Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

2003 • 835 citations

Regulation of Interferon Regulatory Factor-3 by the Hepatitis C Virus Serine Protease

2003 • 799 citations

Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

2003 • 787 citations

Features of systemic lupus erythematosus in Dnase1-deficient mice

2000 • 781 citations

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

2005 • 755 citations

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

2004 • 719 citations

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9

2003 • 690 citations

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1998 • 667 citations

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

2005 • 649 citations

Poxviruses and Immune Evasion

2003 • 639 citations

Recognition and Response in the Plant Immune System

2003 • 596 citations

Coordinated and Distinct Roles for IFN-αβ, IL-12, and IL-15 Regulation of NK Cell Responses to Viral Infection

2002 • 594 citations

The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses

2006 • 588 citations

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

2003 • 512 citations

Complex Modulation of Cell Type-Specific Signaling in Response to Type I Interferons

2006 • 500 citations

Essential Role for the dsRNA-Dependent Protein Kinase PKR in Innate Immunity to Viral Infection

2000 • 491 citations

Essential role of IPS-1 in innate immune responses against RNA viruses

2006 • 483 citations

Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection

2004 • 480 citations

Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

2002 • 476 citations

Antiviral Function of APOBEC3G Can Be Dissociated from Cytidine Deaminase Activity

2005 • 475 citations

Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes

1992 • 447 citations

Cellular APOBEC3G restricts HIV-1 infection in resting CD4+ T cells

2005 • 442 citations

Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes

2004 • 436 citations

Viral and therapeutic control of IFN-β promoter stimulator 1 during hepatitis C virus infection

2006 • 393 citations

Virus interference. II. Some properties of interferon

1957 • 389 citations

Type I Interferon Sensitizes Lymphocytes to Apoptosis and Reduces Resistance to Listeria Infection

2004 • 386 citations

The sor Gene of HIV-1 Is Required for Efficient Virus Transmission in Vitro

1987 • 365 citations

Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA

2004 • 347 citations

Regulation of the type I IFN induction: a current view

2005 • 342 citations

Innate recognition of bacteria by a macrophage cytosolic surveillance pathway

2002 • 282 citations

A FADD-dependent innate immune mechanism in mammalian cells

2004 • 281 citations

Toll-like receptor–independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

2005 • 268 citations

Double-Stranded RNA-Mediated TLR3 Activation Is Enhanced by CD14

2006 • 243 citations

Retroviruses and primate evolution

2000 • 242 citations

An Endogenous Inhibitor of Human Immunodeficiency Virus in Human Lymphocytes Is Overcome by the Viral Vif Protein

1998 • 238 citations

Distinct Requirements for IFNs and STAT1 in NK Cell Function

2000 • 214 citations

IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism

2004 • 203 citations

Transgenic mice with intracellular immunity to influenza virus

1990 • 187 citations

Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes

2006 • 133 citations

Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity

2003 • 130 citations

Connecting Mitochondria and Innate Immunity

2005 • 112 citations

Immune Activation of Type I IFNs by Listeria monocytogenes Occurs Independently of TLR4, TLR2, and Receptor Interacting Protein 2 but Involves TANK-Binding Kinase 1

2005 • 88 citations

Mx Proteins: Gtpases Involved in the Interferon‐Induced Antiviral State

2007 • 56 citations

[Inhibition of vaccinia infection by a liquid factor in tissues infected by homologous virus].

1958 • 41 citations

Bacterial invasion of fibroblasts induces interferon production.

1987 • 37 citations