T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection

Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412

2006 • 2,010 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses

2007 • 1,603 citations

TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES

2004 • 1,320 citations

Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity

2004 • 1,213 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Mechanisms of Immune Evasion by Tumors

2006 • 665 citations

The Emerging Role of CTLA-4 as an Immune Attenuator

1997 • 637 citations

Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15

2003 • 630 citations

Centrosome polarization delivers secretory granules to the immunological synapse

2006 • 603 citations

Targeting tumours with genetically enhanced T lymphocytes

2003 • 508 citations

Adoptive cellular therapy for early cytomegalovirus infection after allogeneic stem-cell transplantation with virus-specific T-cell lines

2003 • 461 citations

Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB

2002 • 438 citations

B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse

2004 • 415 citations

Cytotoxic T-Lymphocyte-Associated Antigen-4 Blockage Can Induce Autoimmune Hypophysitis in Patients With Metastatic Melanoma and Renal Cancer

2005 • 350 citations

Priming of naive T cells inside tumors leads to eradication of established tumors

2004 • 344 citations

Formulation and delivery issues for monoclonal antibody therapeutics

2006 • 330 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activation

2004 • 297 citations

A randomized phase II study of concurrent docetaxel plus vaccine versus vaccine alone in metastatic androgen-independent prostate cancer.

2006 • 291 citations

Eradication of established tumors in mice by a combination antibody-based therapy

2006 • 252 citations

Improving T Cell Therapy for Cancer

2006 • 248 citations

Cancer Patient T Cells Genetically Targeted to Prostate-Specific Membrane Antigen Specifically Lyse Prostate Cancer Cells and Release Cytokines in Response to Prostate-Specific Membrane Antigen

1999 • 229 citations

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

2002 • 225 citations

Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway

1998 • 218 citations

Vascular Targeted Therapy With Anti–Prostate-Specific Membrane Antigen Monoclonal Antibody J591 in Advanced Solid Tumors

2007 • 214 citations

Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells

2000 • 180 citations

Human 4-1BB (CD137) Signals Are Mediated by TRAF2 and Activate Nuclear Factor-κB

1998 • 165 citations

CD8+ Tumor-Infiltrating T Cells Are Deficient in Perforin-Mediated Cytolytic Activity Due to Defective Microtubule-Organizing Center Mobilization and Lytic Granule Exocytosis

2001 • 153 citations

Supernatural T cells: genetic modification of T cells for cancer therapy

2005 • 149 citations

Ex Vivo Expansion and Prophylactic Infusion of CMV-pp65 Peptide-Specific Cytotoxic T-Lymphocytes following Allogeneic Hematopoietic Stem Cell Transplantation

2007 • 131 citations

4-1BBL Cooperates with B7-1 and B7-2 in Converting a B Cell Lymphoma Cell Line into a Long-Lasting Antitumor Vaccine

1999 • 130 citations

Cytotoxic T lymphocytes form an antigen-independent ring junction

2004 • 120 citations

Overview of Tumor Cell–Based Vaccines

2006 • 112 citations

Targeted Elimination of Prostate Cancer by Genetically Directed Human T Lymphocytes

2005 • 110 citations

Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo

2007 • 95 citations

Adenovirus Vector-Mediatedin VivoGene Transfer of OX40 Ligand to Tumor Cells Enhances Antitumor Immunity of Tumor-Bearing Hosts

2004 • 88 citations

Activation of CD4⁺ T cells by delivery of the B7 costimulatory signal on bystander antigen‐presenting cells (trans‐costimulation)

1994 • 86 citations

The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes

1997 • 69 citations

Rapid expansion of cytomegalovirus–specific cytotoxic T lymphocytes by artificial antigen-presenting cells expressing a single HLA allele

2003 • 69 citations

Cross-Linking of 4-1BB Activates TCR-Signaling Pathways in CD8+ T Lymphocytes

2005 • 64 citations

CD80 Cytoplasmic Domain Controls Localization of CD28, CTLA-4, and Protein Kinase Cθ in the Immunological Synapse

2005 • 62 citations

Costimulatory ligand CD70 is delivered to the immunological synapse by shared intracellular trafficking with MHC class II molecules

2007 • 59 citations

Production of Recombinant Human Trimeric CD137L (4-1BBL)

2005 • 56 citations

Human Fibroblasts Transduced with CD80 or CD86 Efficientlytrans-Costimulate CD4+ and CD8+ T Lymphocytes in HLA-Restricted Reactions: Implications for Immune Augmentation Cancer Therapy and Autoimmunity

1999 • 38 citations

Engagement of CD28 Outside of the Immunological Synapse Results in Up-Regulation of IL-2 mRNA Stability but Not IL-2 Transcription

2006 • 34 citations

Impact of the Immunological Synapse on T Cell Signaling

2006 • 14 citations