Labetalol

PHARMACOLOGICAL CHARACTERIZATION OF THE PRESYNAPTIC α‐ADRENOCEPTORS REGULATING CHOLINERGIC ACTIVITY IN THE GUINEA‐PIG ILEUM

1978 • 233 citations

LABETALOL AND PLATELET FUNCTION IN PRE-ECLAMPSIA

1982 • 220 citations

Pharmacology of AH 5158; a drug which blocks both α‐ and β‐adrenoceptors

1972 • 212 citations

Labetalol: A Review of Its Pharmacology, Pharmacokinetics, Clinical Uses and Adverse Effects

1983 • 169 citations

A review of the animal pharmacology of labetalol, a combined alpha- and beta-adrenoceptor-blocking drug.

1976 • 138 citations

A comparison of labetalol plus hospitalization versus hospitalization alone in the management of preeclampsia remote from term

1988 • 134 citations

Prazosin, a selective antagonist of post-synaptic alpha-adrenoceptors [proceedings].

1977 • 123 citations

Use of labetalol in the treatment of severe hypertension during pregnancy.

1979 • 114 citations

Metabolism of labetalol by animals and man.

1976 • 114 citations

A comparative trial of labetalol and hydralazine in the acute management of severe hypertension complicating pregnancy

1988 • 109 citations

Intravenous labetalol in the treatment of severe hypertension and hypertensive emergencies

1983 • 105 citations

THE α‐ AND β‐ADRENOCEPTOR BLOCKING POTENCIES OF LABETALOL AND ITS INDIVIDUAL STEREOISOMERS IN ANAESTHETIZED DOGS AND IN ISOLATED TISSUES

1982 • 105 citations

Labetalol

1978 • 96 citations

Comparison of antihypertensive efficacy and perinatal safety of labetalol and methyldopa in the treatment of hypertension in pregnancy: a randomized controlled trial

1988 • 95 citations

Pharmacological basis for antihypertensive effects of intravenous labetalol.

1977 • 85 citations

Labetalol does not alter the placental and fetal blood flow or maternal prostanoids in pre‐eclampsia

1986 • 84 citations

The use of labetalol for attenuation of the hypertensive response to endotracheal incubation in preeclampsia

1988 • 83 citations

Pharmacological effects of labetalol in man.

1976 • 79 citations

Decreased first-pass metabolism of labetalol in chronic liver disease.

1978 • 77 citations

Drug Kinetics and Hepatic Blood Flow

1979 • 76 citations

"Third drug" trial: comparative study of antihypertensive agents added to treatment when blood pressure remains uncontrolled by a beta blocker plus thiazide diuretic.

1984 • 65 citations

The acute changes seen in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients during the early phases of digoxin therapy are not found during chronic therapy: pharmacological and therapeutic implications for chronic digoxin therapy.

1979 • 64 citations

Intravenous Labetalol and Intravenous Dihydralazine in Severe Hypertension in Pregnancy

1982 • 64 citations

The influence of food on the oral and intravenous pharmacokinetics of a high clearance drug: a study with labetalol.

1982 • 63 citations

Drug Therapy in Patients Undergoing Peritoneal Dialysis Clinical Pharmacokinetic Considerations

1985 • 63 citations

Intravenous labetalol in the management of severe hypertension and hypertensive emergencies

1984 • 60 citations

Acute effect of an antihypertensive drug, labetalol, on uteroplacental blood flow

1982 • 60 citations

Intravenous Labetalol for Treatment of Postoperative Hypertension

1987 • 59 citations

Bullous lichen planus caused by labetalol.

1978 • 58 citations

Clinical Pharmacokinetics of Labetalol

1984 • 58 citations

LABETALOL TO CONTROL BLOOD PRESSURE AFTER CEREBROVASCULAR SURGERY

1988 • 55 citations

Pharmacological effects of labetalol in man.

1976 • 55 citations

Bioavailability of labetalol increases with age.

1982 • 54 citations

Effects of combined alpha and beta adrenoceptor blockade in patients with angina pectoris. A double blind study comparing labetalol with placebo.

1985 • 53 citations

Labetalol infusion in acute myocardial infarction with systemic hypertension.

1979 • 53 citations

Pharmacokinetics of labetalol in healthy volunteers.

1981 • 52 citations

Labetalol therapy in patients with systemic hypertension and angina pectoris: effects of combined alpha and beta adrenoceptor blockade

1981 • 52 citations

Pharmacokinetics and pharmacodynamic studies of labetalol in hypertensive subjects.

1979 • 51 citations

Some Haemodynamic Effects of Compound AH 5158 Compared with Propranolol, Propranolol plus Hydrallazine, and Diazoxide: The Use of AH 5158 in the Treatment of Hypertension

1974 • 51 citations

Labetalol disposition and concentration‐effect relationships during pregnancy.

1983 • 51 citations

Monotherapy with labetalol compared with propranolol. Differential effects by race.

1985 • 50 citations

Hypertension in pregnancy: evaluation of two beta blockers atenolol and labetalol

1983 • 49 citations

Transfer of labetalol into amniotic fluid and breast milk in lactating women

1985 • 46 citations

Controlled comparison of labetalol and propranolol in the management of severe hypertension.

1976 • 46 citations

Comparison of labetalol and dihydralazine in hypertensive emergencies of pregnancy.

1987 • 45 citations

Antihypertensive and metabolic effects of nifedipine and labetalol alone and in combination in primary hypertension

1985 • 45 citations

The evaluation of labetalol in the treatment of hypertension complicating pregnancy.

1982 • 44 citations

Induced hypotension with labetalol for orthognathic surgery

1987 • 44 citations

Intravenous Labetalol and Intravenous Diazoxide in Severe Hypertension Complicating Pregnancy

1986 • 43 citations

Labetalol-induced toxic myopathy.

1981 • 43 citations

Study of single and multiple dose pharmacokinetic/pharmacodynamic modeling of the antihypertensive effects of labetalol

1983 • 42 citations

Multiclinic comparison of labetalol to metoprolol in treatment of mild to moderate systemic hypertension

1983 • 40 citations

Hemodynamic and coronary effects of intravenous labetalol in coronary artery disease

1982 • 40 citations

Circulatory effects of labetalol during halothane anaesthesia

1978 • 38 citations

Elimination kinetics of labetalol in severe renal failure.

1982 • 37 citations

Short- and long-term (six-year) hemodynamic effects of labetalol in essential hypertension

1983 • 36 citations

Labetalol infusion in hypertensive emergencies

1985 • 34 citations

I.V. LABETALOL IN THE TREATMENT OF HYPERTENSION FOLLOWING CORONARY-ARTERY SURGERY

1982 • 34 citations

Chronic effects of labetalol, pindolol, and propranolol on calf blood flow in intermittent claudication

1985 • 33 citations

A Double-Blind Comparison of Verapamil and Labetalol in Hypertensive Patients with Coexisting Chronic Obstructive Airways Disease

1982 • 33 citations

Effects of labetalol on left ventricular mass and function in hypertension — An assessment by serial echocardiography

1984 • 32 citations

Experience with labetalol in hypertension.

1976 • 32 citations

Labetalol in the treatment of patients with hypertension and renal function impairment.

1979 • 31 citations

Multicenter clinical evaluation of long-term efficacy and safety of labetalol in treatment of hypertension

1983 • 31 citations

Labetalol as a hypotensive agent for middle ear microsurgery

1987 • 29 citations

Labetalol: Bioavailability, Drug Plasma Levels, Plasma Renin and Catecholamines in Acute and Chronic Treatment of Resistant Hypertension

1978 • 27 citations

Effect of food on the bioavailability of labetalol.

1980 • 27 citations

DIRECT VASODILATATION BY LABETALOL IN ANAESTHETIZED DOGS

1980 • 27 citations

The effects of enzyme induction and enzyme inhibition on labetalol pharmacokinetics.

1984 • 26 citations

Labetalol, Beta Blockers, and Acute Deterioration of Chronic Airway Obstruction

1982 • 25 citations

Comparative haemodynamic dose response effects of propranolol and labetalol in coronary heart disease.

1982 • 25 citations

Determination of labetalol in human plasma by high-performance liquid chromatography

1979 • 24 citations

Renal haemodynamics after chronic treatment with labetalol and propranolol.

1982 • 24 citations

A Comparative Study of the Effects of Adrenoceptor Antagonists on Platelet Aggregation and Thromboxane Generation

1985 • 24 citations

Alpha-adrenoceptor blockade by labetalol during long-term dosing

1983 • 23 citations

Effect of labetalol on indices of myocardial necrosis in patients with suspected acute infarction

1987 • 23 citations

Comparison of the effects of single doses of atenolol and labetalol on airways obstruction in patients with hypertension and asthma.

1983 • 22 citations

Antihypertensive effectiveness of intravenous labetalol in accelerated hypertension.

1983 • 22 citations

Review of long‐term treatment with labetalol.

1982 • 22 citations

CHARACTERIZATION AND LOCALIZATION OF [³H]-CLONIDINE BINDING IN MEMBRANES PREPARED FROM GUINEA-PIG SPLEEN

1982 • 22 citations

Comparison of beta-adrenoceptor blockers and calcium antagonists in hypertension.

1983 • 21 citations

Comparison of the clinical pharmacokinetics and concentration‐effect relationships for medroxalol and labetalol.

1984 • 21 citations

A study of labetalol in patients of European, West Indian and West African origin.

1976 • 21 citations

The disposition and dynamics of labetalol in patients on dialysis

1986 • 21 citations

The short term effects of propranolol, atenolol and labetalol on antipyrine kinetics in normal subjects.

1982 • 21 citations

Intravenous labetalol in severe hypertension.

1982 • 21 citations

Propranolol vs metoprolol vs labetalol: A comparative study in essential hypertension

1984 • 20 citations

The use of labetalol in Japan: results of multicentre clinical trials.

1982 • 20 citations

Effects of Labetalol on Plasma Renin, Aldosterone, and Catecholamines in Hypertensive Patients

1979 • 19 citations

Some further evidence for partial agonist activity of labetalol.

1980 • 19 citations

Influence of labetalol, propranolol and practolol in patients with asthma.

1982 • 19 citations

A comparison of labetalol, acebutolol, and lidocaine for controlling the cardiovascular responses to endotracheal intubation for oral surgical procedures

1987 • 19 citations

Comparison of the effects of propranolol and labetalol on renal haemodynamics at rest and during exercise in essential hypertension

1980 • 19 citations

Labetalol steady‐state pharmacokinetics in hypertensive patients.

1982 • 18 citations

Clinical Evaluation of Intravenous Labetalol for the Treatment of Hypertensive Urgency

1988 • 18 citations

The treatment of hypertension in pregnancy

1982 • 18 citations

Treatment of hypertension following endotracheal intubation. A study comparing the efficacy of labetalol, practolol and placebo.

1983 • 18 citations

Hemodynamic effects of intravenous labetalol in essential hypertension

1983 • 17 citations

Comparison of the effects of labetalol and hydrochlorothiazide on the ventilatory function of hypertensive patients with mild chronic obstructive pulmonary disease

1983 • 17 citations

PROLACTIN STIMULATION BY INTRAVENOUS LABETALOL IS MEDIATED INSIDE THE CENTRAL NERVOUS SYSTEM

1982 • 17 citations

The Combined Alpha‐ and Beta‐Adrenergic Blocker Labetalol and Propranolol in the Treatment of High Blood Pressure: Similarities and Differences

1984 • 17 citations

Labetalol in the Treatment of Hypertension in Elderly and Younger Patients

1987 • 17 citations

The effects of treatments with labetalol and hydrochlorothiazide on ventilatory function of asthmatic hypertensive patients with demonstrated bronchosensitivity to propranolol.

1985 • 16 citations

Comparative trial of labetalol and acebutolol, alone or associated with dihydralazine, in treatment of essential hypertension.

1980 • 15 citations

Intravenous Labetalol for the Control of Hypertension Following Repair of Coarctation of the Aorta

1988 • 15 citations

A Modification of Allen's Test to Detect Aberrant Ulnar Collateral Circulation

1983 • 15 citations

Evaluation of I.V. labetalol for treatment of posttraumatic hyperdynamic state

1984 • 15 citations

Response of the systemic pulmonary circulation to labetalol at rest and during exercise.

1982 • 15 citations

Effects of chronic alpha and beta adrenoceptor blockade with labetalol on plasma catecholamines and renal function in hypertension

1980 • 15 citations

Comparison of the Effects of Labetalol and Hydrochlorothiazide on the Ventilatory Function of Hypertensive Patients with Asthma and Propranolol Sensitivity

1985 • 15 citations

Labetalol in general practice: a review.

1982 • 15 citations

Acute Hemodynamic Effects of Labetalol in Severe Hypertension

1982 • 14 citations

A long‐term study of labetalol in general practice.

1979 • 14 citations

Raynaud's Phenomenon Caused by β‐Receptor Blocking Drugs

1984 • 14 citations

Treatment of severe hypertension with intravenous labetalol

1982 • 14 citations

Labetalol compared with propranolol in the treatment of black hypertensive patients.

1987 • 14 citations

Effects of Long‐term Therapy with Labetalol on Lipoprotein Metabolism in Patients with Mild Hypertension

1985 • 14 citations

Labetalol, a combined α– and β–blocker, in hypertension of pregnancy

1982 • 14 citations

Intrinsic activity of labetalol on guinea-pig isolated trachea

1981 • 14 citations

Treatment of hypertension in the elderly with labetalol

1982 • 14 citations

Systemic, pulmonary, and coronary hemodynamic effects of labetalol in hypertensive subjects

1983 • 13 citations

Comparison of labetalol and propranolol in hypertension.

1980 • 13 citations

Treatment of severe hypertension with labetalol compared with methyldopa and furosemide

1983 • 12 citations

Endocrine and Metabolic Effects of Labetalol in Man

1981 • 12 citations

Rising Multiple‐Dose Pharmacokinetics of Labetalol in Hypertensive Patients

1986 • 11 citations

Labealol in the treatment of stable exertional angina pectoris: a comparison with nifedipine

1988 • 11 citations

Role of labetalol in acute myocardial infarction.

1982 • 11 citations

Intrinsic Sympathomimetic Activity of Labetalol

1986 • 11 citations

Effect of indoramin, labetalol and alinidine on sympathetic function in normal man.

1984 • 10 citations

Side-effects with long-term labetalol: an open study of 251 patients in a single centre.

1983 • 10 citations

Effects of Combined α- and β-Receptor Blockade on Peripheral Circulation in Essential Hypertension

1981 • 10 citations

Effect of labetalol on plasma catecholamines at rest and during increased sympathetic activity.

1980 • 10 citations

EFFECT OF LABETALOL ON HUMAN PLATELET FUNCTION

1988 • 10 citations

Effects of combined alpha‐ and beta‐blockade by labetalol in patients with coronary artery disease.

1982 • 10 citations

Clinical evaluation of labetalol alone and combined with chlorthalidone in essential hypertension: A double-blind multicentre controlled study

1982 • 10 citations

Monotherapy with labetalol in the treatment of mild hypertension: A double-blind study

1983 • 10 citations

Double-blind trial comparing labetalol with atenolol in the treatment of systemic hypertension with angina pectoris

1985 • 9 citations

Hemodynamic Effects of Labetalol in Patients with Combined Hypertension and Left Ventricular Failure

1988 • 9 citations

Labetalol and hydrochlorothiazide in hypertension

1985 • 9 citations

Labetalol as monotherapy in hypertensive black patients.

1985 • 9 citations

Labetalol by continuous intravenous infusion in severe hypertension.

1986 • 9 citations

Oral labetalol in the management of stable angina pectoris in normotensive patients.

1985 • 9 citations

Fever induced by labetalol.

1986 • 9 citations

Diazoxide and labetalol in acute hypertension during haemodialysis

1983 • 8 citations

Changes in blood pressure and thermographic values resulting from use of a beta-blocker plus diuretic and of an alpha-beta-blocker plus diuretic.

1985 • 8 citations

Comparative effects of adimolol, labetalol and propranolol on heart rate and blood pressure in man.

1985 • 8 citations

Systemic and coronary hemodynamics of labetalol in normotensive patients with ischemic heart disease

1988 • 8 citations

The treatment of hypertension by labetalol‐a new alpha‐ and beta‐adrenoreceptor blocking agent

1982 • 8 citations

The Effect of Labetalol on Contractility of Human Myometrial Preparations

1987 • 8 citations

Improved liquid-chromatographic assay of labetalol in plasma.

1987 • 8 citations

The response of plasma catecholamines to intravenous labetalol: A comparison with sodium nitroprusside

1983 • 7 citations

Beta blockade by oral propranolol and labetalol

1985 • 7 citations

LONG‐TERM EXPERIENCES WITH LABETALOL

1980 • 7 citations

Properties of labetalol, a combined ?-and ?-blocking agent, relevant to the treatment of myocardial ischemia

1988 • 7 citations

On the combination of α- and β-adrenoceptor blockade in hypertension

1983 • 7 citations

Effect of Single Doses of Labetalol, Metoprolol, and Placebo on Ventflatory Function in Patients with Bronchial Asthma: Interaction with Isoproterenol

1986 • 7 citations

An Analysis of the Blood Pressure Response to Labetalol in Hypertensive Patients

1981 • 7 citations

[Maternal effects and perinatal safety of labetalol in the treatment of hypertension in pregnancy. Comparison with methyldopa in a randomized cooperative trial].

1987 • 7 citations

Mean steady‐state plasma concentrations of labetalol in patients undergoing antihypertensive therapy.

1979 • 7 citations

Haemodynamic and metabolic effects of combined adrenergic α‐ and β‐receptor blockade with labetalol in the exercising human forearm

1980 • 7 citations

Effect of Labetalol on Preload in Acute Myocardial Infarction with Systemic Hypertension

1984 • 7 citations

BEAT-BY-BEAT CARDIOVASCULAR RESPONSES TO RAPID SEQUENCE INDUCTION IN HUMANS

1987 • 6 citations

Magnitude and mechanisms of the antihypertensive action of labetalol, including ambulatory assessment.

1983 • 6 citations

Labetalol in the treatment of elderly patients with mild essential hypertension

1988 • 6 citations

Effect of labetalol and propranolol on human cutaneous vasoconstrictor response to adrenaline.

1984 • 6 citations

Comparison of labetalol and clonidine in hypertension

1982 • 6 citations

Diazoxide vs labetalol: a cross-over comparison of short-term effects in hypertension.

1983 • 6 citations

Effects of labetalol and propranolol on the peripheral circulation in hypertensive patients

1982 • 6 citations

Proceedings: The effects of AH 5158 on the overflow of transmitter and the uptake of (3H)-(--)-noradrenaline in the cat spleen.

1976 • 6 citations

Haemodynamic dose-response effects of intravenous labetalol in acute myocardial infarction.

1983 • 6 citations

Low starting dose labetalol — a new approach for the elderly hypertensive

1986 • 5 citations

Cutaneous reaction to labetalol.

1978 • 5 citations

Effects of atenolol, labetalol and propranolol on the peripheral circulation in hypertensive patients without obstructive vascular disease

1985 • 5 citations

Single–dose pharmacokinetics of labetalol in healthy young men

1982 • 5 citations

Use of labetalol in trauma

1988 • 5 citations

Comparison of labetalol and prazosin in hypertensive patients using automated ambulatory monitoring

1988 • 4 citations

Labetalol blockade of central α- and β-noradrenergic receptors in rat brain homogenates

1980 • 4 citations

[Arterial hypertension in the elderly. Double-blind study versus placebo of the efficacy and tolerability of an alpha-beta blocker: labetalol].

1987 • 4 citations

Antihypertensive and metabolic effects of increasing doses of atenolol and labetalol. A comparative study in primary hypertension

1982 • 4 citations

Beneficial effect of labetalol in hypertensive patients with angina pectoris.

1983 • 4 citations

A comparison of glyceryl trinitrate and labetalol as hypotensive agents in microsurgery of the middle ear

1988 • 4 citations

INTRAVENOUS LABETALOL FOR BLOOD PRESSURE REDUCTION FOLLOWING MYOCARDIAL REVASCULARIZATION

1987 • 4 citations

Acute effect of labetalol on hypertensive brachial artery.

1987 • 4 citations

Labetalol in the treatment of elderly patients with mild essential hypertension

1988 • 4 citations

Antihypertensive therapy with diuretics and beta-blockers at fixed dosage: comparison between the combinations labetalol plus chlorthalidone and atenolol plus chlorthalidone.

1985 • 3 citations

Combined labetalol plus flunarizine treatment for arterial hypertension.

1984 • 3 citations

Evolution of renal function under chronic oral administration of labetalol.

1987 • 3 citations

Haemodynamic effects of intravenous labetalol in hypertensive patients with obstructive coronary heart disease complicated by acute myocardial infarction of recent origin

1983 • 3 citations

Hemodynamic effects of labetalol in healthy volunteers.

1982 • 3 citations

Acute effect of labetalol on blood pressure in relation to the sympathetic nervous system and plasma renin activity

1984 • 3 citations

A comparison of the effects of combined or separate alpha- and beta-blockade in the treatment of hypertension in the acute stage of myocardial infarction

1986 • 3 citations

Effects of Labetalol (400 mg/day) on Plasma Lipids, Lipoproteins and Apolipoproteins in Hypertensive Patients

1985 • 2 citations

Cold sensitivity in essential hypertension: the effect of beta- and combined alpha- and beta-blockade

1985 • 2 citations

A comparison of labetalol and prazosin combined with atenolol in non-responders to atenolol plus hydrochlorothiazide in uncomplicated hypertension

1985 • 2 citations

Labetalol in resistant hypertension

1982 • 2 citations

IV. Labetalol in the management of severe hypertension.

1981 • 1 citations

[Hemodynamic effects of labetalol on the humeral artery of the hypertensive patient. A double-blind study versus placebo].

1987 • 1 citations

Low starting dose labetalol--a new approach for the elderly hypertensive.

1986 • 1 citations

Interaction of Clonidine and Labetalol in Hypertension

1983 • 1 citations

Intravenous Labetalol in the Management of Resistant Hypertensive Emergency

1987 • 1 citations