Genetics of drug transformation

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 • 647 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Metabolic oxidation phenotypes as markers for susceptibility to lung cancer

1984 • 386 citations

MEDICAL NEMESIS

1974 • 377 citations

Pharmacogenetics of mephenytoin: A new drug hydroxylation polymorphism in man

1984 • 368 citations

Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative drug metabolism.

1985 • 319 citations

Principles of medical pharmacology

1989 • 307 citations

ON DISTRIBUTION AND INHERITANCE OF ATYPICAL FORMS OF HUMAN SERUM CHOLINESTERASE, AS INDICATED BY DIBUCAINE NUMBERS

1957 • 296 citations

Frontiers in Biochemical and Pharmacological Research in Depression

1984 • 278 citations

Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis.

1954 • 231 citations

Relationship between facial flushing and blood acetaldehyde levels after alcohol intake

1979 • 221 citations

Differential stereoselective metabolism of metoprolol in extensive and poor debrisoquin metabolizers

1983 • 215 citations

Isolation and purification of cytochrome P-450, and the existence of multiple forms

1979 • 210 citations

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.

1985 • 173 citations

Psychopharmacology of alcohol

1980 • 170 citations

Genetic polymorphism of mephenytoin p(4′)‐hydroxylation: difference between Orientals and Caucasians.

1985 • 111 citations

Human cytochromes P-450

1984 • 99 citations

Influence of genetic polymorphism on the metabolism and disposition of encainide in man.

1984 • 90 citations

Enzymatische Inaktivierung von Isonicotins�urehydrazid im menschlichen und tierischen Organismus

1953 • 88 citations

Polymorphic ability to metabolize propranolol alters 4-hydroxypropranolol levels but not beta blockade

1984 • 81 citations

Polymorphic hydroxylation of perhexiline maleate in man.

1984 • 69 citations

Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation

1986 • 68 citations

Influence of the defective metabolism of sparteine on its pharmacokinetics

1979 • 67 citations

Biology of disease. Alcoholism and aldehydism: new biomedical concepts.

1984 • 66 citations

The role of alcohol dehydrogenase and aldehyde dehydrogenase isozymes in alcohol metabolism, alcohol sensitivity, and alcoholism.

1983 • 66 citations

Hepatology: A Festschrift for Hans Popper

1985 • 64 citations

Assay and characterisation of debrisoquine 4‐hydroxylase activity of microsomal fractions of human liver.

1982 • 64 citations

Dissociation of co-regulatory control of debrisoquin/phenformin and sparteine oxidation in Ghanaians

1985 • 63 citations

Role of oxidation polymorphism on blood and urine concentrations of amitriptyline and its metabolites in man

1982 • 61 citations

Influence of oxidation polymorphism on phenformin kinetics and dynamics

1983 • 60 citations

Genetically determined oxidation capacity and the disposition of debrisoquine.

1983 • 60 citations

The polymorphic 4-hydroxylation of debrisoquine in a Saudi arab population

1980 • 59 citations

A Population and Familial Study of the Defective Alicyclic Hydroxylation of Debrisoquine among Egyptians

1979 • 57 citations

Stereoselective metabolism and disposition of the enantiomers of mephenytoin during chronic oral administration of the racemic drug in man.

1982 • 52 citations

Genetic variability in responses to chemical exposure

1985 • 47 citations

Inter-ethnic difference in sparteine oxidation among Ghanaians and Germans

1985 • 44 citations

Bufuralol metabolism in human liver: a sensitive probe for the debrisoquine‐type polymorphism of drug oxidation

1984 • 40 citations

Influence of DH/DL alleles regulating debrisoquine oxidation on phenytoin hydroxylation

1981 • 39 citations

A method for studying drug metabolism in populations: Racial differences in amobarbital metabolism

1979 • 39 citations

Metabolism of methoxyphenamine in extensive and poor metabolizers of debrisoquin

1985 • 37 citations

Clinical pharmacology of antidepressant drugs: pharmacogenetics.

1984 • 33 citations

Relationship of N-demethylation of amiflamine and its metabolite to debrisoquine hydroxylation polymorphism

1984 • 32 citations

Genetically determined debrisoquine oxidation capacity in bladder cancer

1984 • 32 citations

A human cytochrome P-450 characterized by inhibition studies as the sparteine–debrisoquine monooxygenase

1984 • 32 citations

The genetic defect of mephenytoin hydroxylation

1986 • 27 citations

Sparteine sulfate: A potent, capricious oxytocic

1966 • 24 citations

Pharmacogenetic Perspectives: Genes, Drugs and Disease

1984 • 21 citations

The polymorphisms of alcohol and aldehyde dehydrogenase and their significance for acetaldehyde toxicity

1983 • 20 citations

Oxidation phenotype and the metabolism and action of beta-blockers

1985 • 20 citations

The fate of orally administered [4-^l4C]phenytoin in two healthy male volunteers

1983 • 8 citations

Debrisoquine phenotyping in epileptic patients treated with phenytoin and carbamazepine

1985 • 6 citations

High affinity of quinidine for a stereoselective microsomal binding site as determined by a radioreceptor assay

1984 • 6 citations

The occurrence of two hepatic microsomal sites for amobarbital hydroxylation

1983 • 6 citations

Commentary: drug metabolism and pharmacogenetics.

1983 • 5 citations