Fetal hippocampal CA3 cell grafts enriched with fibroblast growth factor‐2 exhibit enhanced neuronal integration into the lesioned aging rat hippocampus in a kainate model of temporal lobe epilepsy

The efficiency of systematic sampling in stereology and its prediction*

1987 • 3,508 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

The unbiased estimation of number and sizes of arbitrary particles using the disector

1984 • 2,539 citations

Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

1993 • 2,272 citations

Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.

1986 • 1,669 citations

Stereology of arbitrary particles*

1986 • 1,404 citations

Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain.

1995 • 1,014 citations

Cell replacement therapies for central nervous system disorders

2000 • 948 citations

Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS

1999 • 916 citations

Neuropathological Evidence of Graft Survival and Striatal Reinnervation after the Transplantation of Fetal Mesencephalic Tissue in a Patient with Parkinson's Disease

1995 • 857 citations

Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

1978 • 745 citations

Mitochondrial defect in Huntington's disease caudate nucleus

1996 • 737 citations

Kainic acid seizures in the rat

1994 • 693 citations

Basic and acidic fibroblast growth factors have trophic effects on neurons from multiple CNS regions

1988 • 529 citations

Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate‐treated rats

1997 • 501 citations

Fetal Nigral Transplantation as a Therapy for Parkinson’s Disease

2006 • 411 citations

Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats

1997 • 400 citations

Mosaic organization of the hippocampal neuroepithelium and the multiple germinal sources of dentate granule cells

1990 • 395 citations

Selective reinnervation of hippocampal area CA1 and the fascia dentata after destruction of CA3-CA4 afferents with kainic acid

1980 • 380 citations

Stimulation of Neonatal and Adult Brain Neurogenesis by Subcutaneous Injection of Basic Fibroblast Growth Factor

1999 • 375 citations

Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin

1995 • 339 citations

Improving the Survival of Grafted Dopaminergic Neurons: A Review over Current Approaches

2000 • 328 citations

Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain

1991 • 295 citations

Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease

1998 • 295 citations

Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis

2000 • 281 citations

Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus

1991 • 280 citations

Highly Specific Neuron Loss Preserves Lateral Inhibitory Circuits in the Dentate Gyrus of Kainate-Induced Epileptic Rats

1999 • 273 citations

Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid

1980 • 257 citations

Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats

1998 • 219 citations

BDNF mRNA expression in the developing rat brain following kainic acid-induced seizure activity

1992 • 215 citations

Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease

1995 • 211 citations

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

1993 • 198 citations

Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD

2001 • 164 citations

Induction of activin A is essential for the neuroprotective action of basic fibroblast growth factor in vivo

2000 • 153 citations

Endogenous BDNF Protein Is Increased in Adult Rat Hippocampus after a Kainic Acid Induced Excitotoxic Insult but Exogenous BDNF Is Not Neuroprotective

1998 • 144 citations

Neuronal Cell Loss in the CA3 Subfield of the Hippocampus Following Cortical Contusion Utilizing the Optical Disector Method for Cell Counting

1997 • 139 citations

Are you using neuronal densities, synaptic densities or neurochemical densities as your definitive data? there is a better way to go

1994 • 138 citations

In vitro survival and differentiation of neurons derived from epidermal growth factor-responsive postnatal hippocampal stem cells: Inducing effects of brain-derived neurotrophic factor

1998 • 137 citations

Fibroblast Growth Factor-2 Promotes Axon Branching of Cortical Neurons by Influencing Morphology and Behavior of the Primary Growth Cone

2001 • 136 citations

Recurrent Mossy Fiber Pathway in Rat Dentate Gyrus: Synaptic Currents Evoked in Presence and Absence of Seizure-Induced Growth

1999 • 131 citations

Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion

2001 • 128 citations

Prolonged increases in neurotrophic activity associated with kainate-induced hippocampal synaptic reorganization

1993 • 126 citations

Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide

1998 • 118 citations

Regeneration and Proliferation of Embryonic and Adult Rat Hippocampal Neurons in Culture

1999 • 114 citations

Insulin‐like growth factor‐1 mRNA is increased in deafferented hippocampus: Spatiotemporal correspondence of a trophic event with axon sprouting

1995 • 114 citations

Fetal Hippocampal Grafts Containing CA3 Cells Restore Host Hippocampal Glutamate Decarboxylase-Positive Interneuron Numbers in a Rat Model of Temporal Lobe Epilepsy

2000 • 110 citations

Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons

1991 • 104 citations

Fibroblast Growth Factor 2 Activation of Stromal Cell Vascular Endothelial Growth Factor Expression and Angiogenesis

2001 • 100 citations

Diminished Viability, Growth, and Behavioral Efficacy of Fetal Dopamine Neuron Grafts in Aging Rats with Long-Term Dopamine Depletion: An Argument for Neurotrophic Supplementation

1999 • 87 citations

Functional repair of striatal systems by neural transplants: evidence for circuit reconstruction

1995 • 83 citations

Epidemiology and Drug Treatment of Epilepsy in Elderly People

1999 • 78 citations

aFGF, bFGF and flg mRNAs Show Distinct Patterns of Induction in the Hippocampus Following Kainate‐induced Seizures

1994 • 78 citations

Neural Transplantation in Parkinson's Disease

2000 • 73 citations

DEVELOPMENT OF FETAL HIPPOCAMPAL GRAFTS IN INTACT AND LESIONED HIPPOCAMPUS

1996 • 71 citations

Hippocampal neurons transplanted into ischemically lesioned hippocampus: anatomical assessment of survival, maturation and integration

1991 • 71 citations

Vulnerability of the Dentate Gyrus to Aging and Intracerebroventricular Administration of Kainic Acid

1999 • 65 citations

Neurochemical Changes in the Hippocampus of the Brown Norway Rat During Aging

1997 • 63 citations

Fetal Hippocampal Cells Grafted to Kainate-Lesioned CA3 Region of Adult Hippocampus Suppress Aberrant Supragranular Sprouting of Host Mossy Fibers

1997 • 63 citations

BDNF, and full length and truncated TrkB expression in the hippocampus of the rat following kainic acid excitotoxic damage. Evidence of complex time-dependent and cell-specific responses

1998 • 62 citations

Enhanced cell survival in fetal hippocampal suspension transplants grafted to adult rat hippocampus following kainate lesions: A three-dimensional graft reconstruction study

1995 • 58 citations

Selective Hippocampal Lesions Differentially Affect the Phenotypic Fate of Transplanted Neuronal Precursor Cells

1996 • 57 citations

Implantation of Bioactive Growth Factor-Secreting Rods Enhances Fetal Dopaminergic Graft Survival, Outgrowth Density, and Functional Recovery in a Rat Model of Parkinson's Disease

2000 • 54 citations

Aging impairs axonal sprouting response of dentate granule cells following target loss and partial deafferentation

1999 • 53 citations

Increased NGF-like activity in young but not aged rat hippocampus after septal lesions

1994 • 49 citations

Treatment of epilepsy in the elderly

1999 • 48 citations

Changing Presentation of Seizures with Aging: Clinical and Etiological Factors

1999 • 46 citations

IGF-I and bFGF Improve Dopamine Neuron Survival and Behavioral Outcome in Parkinsonian Rats Receiving Cultured Human Fetal Tissue Strands

2001 • 40 citations

Development of long-distance efferent projections from fetal hippocampal grafts depends upon pathway specificity and graft location in kainate-lesioned adult hippocampus

1997 • 39 citations

Combined neurotrophic supplementation and caspase inhibition enhances survival of fetal hippocampal CA3 cell grafts in lesioned CA3 region of the aging hippocampus

2002 • 39 citations

Entorhinal axons exhibit sprouting in CA1 subfield of the adult hippocampus in a rat model of temporal lobe epilepsy

2002 • 38 citations

Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells

2000 • 37 citations

Non-phosphorylated neurofilament protein immunoreactivity in adult and developing rat hippocampus: specificity and application in grafting studies

1995 • 36 citations

Quantitative Graft Integration of Fetal Hippocampal Transplants Labeled with 5′ Bromodeoxyuridine into Normal Adult Hippocampus

1994 • 35 citations

FGF Induces a Switch in Death Receptor Pathways in Neuronal Cells

2001 • 35 citations

Survival of Grafted Fetal Neural Cells in Kainic Acid Lesioned CA3 Region of Adult Hippocampus Depends upon Cell Specificity

2000 • 33 citations

Fetal Hippocampal CA3 Cell Grafts Transplanted to Lesioned CA3 Region of the Adult Hippocampus Exhibit Long-Term Survival in a Rat Model of Temporal Lobe Epilepsy

2001 • 32 citations

Bilateral Fetal Striatal Grafts in the 3-Nitropropionic Acid-Induced Hypoactive Model of Huntington's Disease

1998 • 28 citations

FGF‐2 Induces Nerve Growth Factor Expression in Cultured Rat Hippocampal Neurons

1997 • 24 citations

Neural grafting of cholinergic neurons in the hippocampal formation

1996 • 23 citations

Prolonged Postlesion Transplantation Delay Adversely Influences Survival of Both Homotopic and Heterotopic Fetal Hippocampal Cell Grafts in Kainate-Lesioned CA3 Region of Adult Hippocampus

2001 • 23 citations

Effects of transplantation of fetal hippocampal or hindbrain tissue into the brains of adult rats with hippocampal lesions on water maze acquisition.

1992 • 23 citations

Effects of transplantation of fetal hippocampal or hindbrain tissue into the brains of adult rats with hippocampal lesions on water maze acquisition.

1992 • 21 citations

Neural Transplantation in Parkinson's Disease

2000 • 20 citations

Biomarkers of 3‐Nitropropionic Acid (3‐NPA)‐Induced Mitochondrial Dysfunction as Indicators of Neuroprotection

2001 • 19 citations

Early onset Alzheimer's disease in a South American pedigree from Argentina

1995 • 16 citations

Neural transplantation to the normal and lesioned brain. An experimental study of the rat hippocampus.

1995 • 11 citations