Neural Transplantation in Parkinson's Disease

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Quantitative recording of rotational behavior in rats after 6-hydroxy-dopamine lesions of the nigrostriatal dopamine system

1970 • 1,980 citations

Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease

1988 • 1,881 citations

Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells

2000 • 1,262 citations

Grafts of Fetal Dopamine Neurons Survive and Improve Motor Function in Parkinson's Disease

1990 • 1,194 citations

TRANSPLANTATION OF EMBRYONIC DOPAMINE NEURONS FOR SEVERE PARKINSON'S DISEASE

2001 • 1,013 citations

Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System

1979 • 963 citations

Cell replacement therapies for central nervous system disorders

2000 • 948 citations

Neuropathological Evidence of Graft Survival and Striatal Reinnervation after the Transplantation of Fetal Mesencephalic Tissue in a Patient with Parkinson's Disease

1995 • 857 citations

Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants

1979 • 830 citations

Immunologically Privileged Sites

1978 • 815 citations

Engraftable human neural stem cells respond to development cues, replace neurons, and express foreign genes

1998 • 776 citations

Survival of Implanted Fetal Dopamine Cells and Neurologic Improvement 12 to 46 Months after Transplantation for Parkinson's Disease

1992 • 757 citations

Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

2000 • 720 citations

Transplantation of adrenal medullary tissue to striatum in parkinsonism

1985 • 601 citations

Time course of nigrostriatal degeneration in parkinson's disease

1976 • 561 citations

Reinnervation of the denervated striatum by substantia nigra transplants: Functional consequences as revealed by pharmacological and sensorimotor testing

1980 • 551 citations

Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats

1998 • 539 citations

Unilateral Transplantation of Human Fetal Mesencephalic Tissue into the Caudate Nucleus of Patients with Parkinson's Disease

1992 • 516 citations

Human Fetal Dopamine Neurons Grafted Into the Striatum in Two Patients With Severe Parkinson's Disease

1989 • 516 citations

In Vitro Expansion of a Multipotent Population of Human Neural Progenitor Cells

1999 • 501 citations

Bilateral Fetal Mesencephalic Grafting in Two Patients with Parkinsonism Induced by 1-Methyl-4-Phenyl-L,2,3,6-Tetrahydropyridine (MPTP)

1992 • 499 citations

Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease

1997 • 469 citations

Evidence for long‐term survival and function of dopaminergic grafts in progressive Parkinson's disease

1994 • 455 citations

NTera 2 Cells: A human cell line which displays characteristics expected of a human committed neuronal progenitor cell

1993 • 435 citations

Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behaviour

1981 • 415 citations

Fetal Nigral Transplantation as a Therapy for Parkinson’s Disease

2006 • 411 citations

Intracerebral grafting of neuronal cell suspensions. I. Introduction and general methods of preparation.

1983 • 403 citations

Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease

1995 • 401 citations

Adrenal Medulla Grafts Enhance Recovery of Striatal Dopaminergic Fibers

1987 • 398 citations

Induction of a midbrain dopaminergic phenotype in Nurr1-overexpressing neural stem cells by type 1 astrocytes

1999 • 373 citations

Transplantation of Cryopreserved Human Embryonal Carcinoma-Derived Neurons (NT2N Cells) Promotes Functional Recovery in Ischemic Rats

1998 • 361 citations

Transplantation of fetal dopamine neurons in Parkinson's disease: One‐year clinical and neurophysiological observations in two patients with putaminal implants

1992 • 360 citations

An [¹⁸F]dopa–PET and clinical study of the rate of progression in Parkinson’s disease

1996 • 359 citations

Short‐ and long‐term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease

1997 • 358 citations

Long-term Evaluation of Bilateral Fetal Nigral Transplantation in Parkinson Disease

1999 • 351 citations

Restoration of dopaminergic function by grafting of fetal rat substantia nigra to the caudate nucleus: Long‐term behavioral, biochemical, and histochemical studies

1980 • 340 citations

The Ethical Problems with Sham Surgery in Clinical Research

1999 • 331 citations

Improving the Survival of Grafted Dopaminergic Neurons: A Review over Current Approaches

2000 • 328 citations

Human Neural Precursor Cells Express Low Levels of Telomerase in Vitro and Show Diminishing Cell Proliferation with Extensive Axonal Outgrowth following Transplantation

2000 • 309 citations

Functional fetal nigral grafts in a patient with Parkinson's disease: Chemoanatomic, ultrastructural, and metabolic studies

1996 • 308 citations

Neuroprotection through Delivery of Glial Cell Line-Derived Neurotrophic Factor by Neural Stem Cells in a Mouse Model of Parkinson's Disease

2001 • 303 citations

Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease

2000 • 299 citations

Differentiation of Mesencephalic Progenitor Cells into Dopaminergic Neurons by Cytokines

1998 • 298 citations

Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis

1988 • 296 citations

Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats

1998 • 295 citations

Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease

1998 • 295 citations

Multicenter Study of Autologous Adrenal Medullary Transplantation to the Corpus Striatum in Patients with Advanced Parkinson's Disease

1989 • 291 citations

Caspase inhibition reduces apoptosis and increases survival of nigral transplants

1999 • 283 citations

Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon

1994 • 277 citations

Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release

1988 • 277 citations

Sequential bilateral transplantation in Parkinson's disease: Effects of the second graft

1999 • 274 citations

Transplantation in Parkinson's disease: Two cases of adrenal medullary grafts to the putamen

1987 • 273 citations

Reformation of the severed septohippocampal cholinergic pathway in the adult rat by transplanted septal neurons

1977 • 264 citations

Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopa

1991 • 261 citations

Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior

1985 • 259 citations

Growth of transplanted monoaminergic neurones into the adult hippocampus along the perforant path

1976 • 256 citations

Transplantation of Human Fetal Dopamine Cells for Parkinson's Disease

1990 • 239 citations

Use of Placebo Surgery in Controlled Trials of a Cellular-Based Therapy for Parkinson's Disease

1999 • 239 citations

Porcine Xenografts in Parkinson's Disease and Huntington's Disease Patients: Preliminary Results

2000 • 229 citations

Lazaroids improve the survival of grafted rat embryonic dopamine neurons.

1994 • 225 citations

Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats

1998 • 219 citations

A microtransplantation approach for cell suspension grafting in the rat parkinson model: A detailed account of the methodology

1994 • 217 citations

The Time Course of Loss of Dopaminergic Neurons and the Gliotic Reaction Surrounding Grafts of Embryonic Mesencephalon to the Striatum

1996 • 207 citations

Cell Survival and Clinical Outcome Following Intrastriatal Transplantation in Parkinson Disease

2001 • 205 citations

Adrenal medullary autografts into the basal ganglia of Cebus monkeys: Injury-induced regeneration

1988 • 205 citations

The retinal pigment epithelium : function and disease

1998 • 183 citations

Long-term outcome of unilaterally transplanted parkinsonian patients

1996 • 176 citations

Xenotransplantation of Porcine Fetal Ventral Mesencephalon in a Rat Model of Parkinson's Disease: Functional Recovery and Graft Morphology

1996 • 171 citations

Graft-derived recovery from 6-OHDA lesions: specificity of ventral mesencephalic graft tissues

1988 • 163 citations

Putative chromaffin cell survival and enhanced host‐derived TH‐Fiber innervation following a functional adrenal medulla autograft for Parkinson's disease

1991 • 159 citations

Neural transplantation of human neuroteratocarcinoma (hNT) neurons into ischemic rats. A quantitative dose–response analysis of cell survival and behavioral recovery

1999 • 156 citations

Autopsy findings in a patient who had an adrenal‐to‐brain transplant for Parkinson's disease

1989 • 155 citations

NGF-like trophic support from peripheral nerve for grafted rhesus adrenal chromaffin cells

1990 • 147 citations

Implantation of Human Fetal Ventral Mesencephalon to the Right Caudate Nucleus in Advanced Parkinson's Disease

1991 • 146 citations

The effect of fetal mesencephalon implants on primate MPTP-induced parkinsonism

1990 • 145 citations

Temporal pattern of host responses against intrastriatal grafts of syngeneic, allogeneic or xenogeneic embryonic neuronal tissue in rats

1995 • 136 citations

Cellular and Functional Recovery of Parkinsonian Rats after Intrastriatal Transplantation of Carotid Body Cell Aggregates

1998 • 135 citations

Prospects of transplantation in human neurodegenerative diseases

1991 • 132 citations

Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease

1995 • 132 citations

Generation of Tyrosine Hydroxylase-Producing Neurons from Precursors of the Embryonic and Adult Forebrain

1999 • 125 citations

Chapter 70 Transient behavioral recovery in hemiparkinsonian primates after adrenal medullary allografts

1988 • 124 citations

Programmed Cell Death in Developing Grafts of Fetal Substantia Nigra

1994 • 120 citations

Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line—derived neurotrophic factor in patients with Parkinson's disease

2000 • 117 citations

Survival and growth of fetal catecholamine neurons transplanted into primate brain

1986 • 115 citations

Fetal nondopaminergic neural implants in parkinsonian primates

1991 • 114 citations

A novel approach to neural transplantation in Parkinson's disease: Use of polymer-encapsulated cell therapy

1992 • 112 citations

The influence of donor age on the survival of solid and suspension intraparenchymal human embryonic nigral grafts

1995 • 110 citations

Is the Brain "An Immunologically Privileged Site"?

1964 • 109 citations

Biochemical and Behavioral Correction of MPTP Parkinson‐like Syndrome by Fetal Cell Transplantation^a

1987 • 101 citations

Functional Effects of Striatal Dysfunction in Parkinson Disease

1997 • 101 citations

Patterns of Cell Death and Dopaminergic Neuron Survival in Intrastriatal Nigral Grafts

1999 • 97 citations

Intrastriatal adrenal medulla grafts in rats

1986 • 96 citations

Cholinergic reinnervation of the rat hippocampus by septal implants is stimulated by perforant path lesion

1979 • 92 citations

Reconstruction of the Nigrostriatal Pathway by Simultaneous Intrastriatal and Intranigral Dopaminergic Transplants

1996 • 87 citations

Diminished Viability, Growth, and Behavioral Efficacy of Fetal Dopamine Neuron Grafts in Aging Rats with Long-Term Dopamine Depletion: An Argument for Neurotrophic Supplementation

1999 • 87 citations

Chapter 62 Transplantation of embryonic marmoset dopaminergic neurons to the corpus striatum of marmosets rendered parkinsonian by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1988 • 83 citations

Adrenal Medullary Transplantation Into the Brain for Treatment of Parkinson's Disease: Clinical Outcome and Neurochemical Studies

1990 • 76 citations

Neural Transplantation in Parkinson's Disease

2000 • 73 citations

Apoptosis in Neuronal Development and Transplantation: Role of Caspases and Trophic Factors

1999 • 72 citations

Sham neurosurgery in patients with Parkinson's disease: is it morally acceptable?

2001 • 71 citations

Adrenal medullary implants in the dopamine-denervated rat striatum. II. Acute behavior as a function of graft amount and location and its modulation by neuroleptics

1984 • 70 citations

Intrastriatal and Intranigral Grafting of hNT Neurons in the 6-OHDA Rat Model of Parkinson's Disease

2000 • 70 citations

Autologous Transplantation of Adrenal Medulla in Parkinson's Disease

1990 • 68 citations

Long-term improvement in patients with severe Parkinson's disease after implantation of fetal ventral mesencephalic tissue in a cavity of the caudate nucleus: 5-year follow up in 10 patients

1997 • 65 citations

Enhancement of Sensorimotor Behavioral Recovery in Hemiparkinsonian Rats with Intrastriatal, Intranigral, and Intrasubthalamic Nucleus Dopaminergic Transplants

2001 • 65 citations

Lithium Chloride Induces the Expression of Tyrosine Hydroxylase in hNT Neurons

1999 • 64 citations

Adrenal Medullary Autograft Transplantation Into the Striatum of Patients With Parkinson's Disease

1989 • 64 citations

A comparative study of preparation techniques for improving the viability of nigral grafts using vital stains, in vitro cultures, and in vivo grafts

1995 • 64 citations

Cell Replacement Strategies for Neurodegenerative Disorders

2000 • 62 citations

The Adrenal Medullary Transplant Operation for Park in son's Disease : Clinical Observations in Five Patients

1988 • 61 citations

Expression of tyrosine hydroxylase in an immortalized human fetal astrocyte cell line: In vitro characterization and engraftment into the rodent striatum

1996 • 61 citations

Clinical study of fetal mesencephalic intracerebral transplants for the treatment of Parkinson's disease

1996 • 55 citations

Survival and immunogenicity of dissociated allogeneic fetal neural dopamine-rich grafts when implanted into the brains of adult mice

1989 • 54 citations

Survival of Rat and Porcine Sertoli Cell Transplants in the Rat Striatum without Cyclosporine-A Immunosuppression

1997 • 53 citations

Sertoli cells enhance the survival of co-transplanted dopamine neurons

1999 • 49 citations

Chapter 61 Cross-species intracerebral grafting of embryonic swine dopaminergic neurons

1988 • 48 citations

Sertoli cells decrease microglial response and increase engraftment of human hNT neurons in the hemiparkinsonian rat striatum

1999 • 45 citations

A non-invasive transport system for GDNF across the blood–brain barrier

1997 • 44 citations

Development of fetal neural transplantation as a treatment for Parkinson's disease

1999 • 33 citations

Utilization of unilateral and bilateral stereotactically placed adrenomedullary-striatal autografts in parkinsonian humans

1990 • 31 citations

Bilateral Fetal Grafts for Parkinson's Disease: 22 Months' Results

1992 • 30 citations

Inhibitory effects of calcium antagonists on mitochondrial swelling induced by lipid peroxidation or amchidonic acid in the rat brain in vitro

1994 • 29 citations

Functional Repair with Neural Stem Cells

2000 • 25 citations

Delayed implantation of nigral grafts improves survival of dopamine neurones and rate of functional recovery

1999 • 25 citations

Allogeneic grafts of fetal dopamine neurons: Behavioral indices of immunological interactions

1994 • 23 citations

Neurons from stem cells: Implications for understanding nervous system development and repair

2000 • 22 citations

A long term follow-up of fetal dopaminergic neurons transplantation into the brain of three parkinsonian patients

1994 • 16 citations

The Lund Transplant Program for Parkinson’s Disease and Patients with MPTP-Induced Parkinsonism

1998 • 15 citations

Immunological reactions to neural grafts in the central nervous system

1991 • 14 citations

Chimeric brain: theoretical and clinical aspects.

1997 • 9 citations

Neural transplantation: can we improve the symptomatic relief?

1999 • 5 citations

Stroke Rescue

1998 • 4 citations

Deleted Work

1955 • 0 citations