Implantation of Bioactive Growth Factor-Secreting Rods Enhances Fetal Dopaminergic Graft Survival, Outgrowth Density, and Functional Recovery in a Rat Model of Parkinson's Disease

Estimation of nuclear population from microtome sections

1946 • 4,378 citations

CNS stem cells express a new class of intermediate filament protein

1990 • 3,138 citations

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

1995 • 1,084 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

Brain Grafts Reduce Motor Abnormalities Produced by Destruction of Nigrostriatal Dopamine System

1979 • 963 citations

Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants

1979 • 830 citations

Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain

1995 • 659 citations

Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats

1998 • 539 citations

Selective and nonselective stimulation of central cholinergic and dopaminergic development in vitro by nerve growth factor, basic fibroblast growth factor, epidermal growth factor, insulin and the insulin-like growth factors I and II

1990 • 529 citations

Proliferation, differentiation, and long-term culture of primary hippocampal neurons.

1993 • 461 citations

Postmitotic death is the fate of constitutively proliferating cells in the subependymal layer of the adult mouse brain

1992 • 393 citations

Glial Cell Line-Derived Neurotrophic Factor Is Expressed in the Developing but Not Adult Striatum and Stimulates Developing Dopamine Neurons in Vivo

1993 • 384 citations

Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: a tyrosine hydroxylase immunocytochemical study

1985 • 339 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system

1991 • 303 citations

Epidermal Growth Factor Immunoreactive Material in the Central Nervous System: Location and Development

1984 • 266 citations

Expression of FGF receptor gene in rat development

1991 • 264 citations

Chronic implants of chromaffin tissue into the dopamine-denervated striatum. Effects of NGF on graft survival, fiber growth and rotational behavior

1985 • 259 citations

Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro

1990 • 257 citations

Substantia nigra transplants into denervated striatum of the rat: Ultrastructure of graft and host interconnections

1985 • 247 citations

TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons

1994 • 245 citations

Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo

1995 • 237 citations

Glial Cell Line-Derived Neurotrophic Factor Requires Transforming Growth Factor-β for Exerting Its Full Neurotrophic Potential on Peripheral and CNS Neurons

1998 • 232 citations

Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats

1998 • 219 citations

A microtransplantation approach for cell suspension grafting in the rat parkinson model: A detailed account of the methodology

1994 • 217 citations

Correspondence

1996 • 215 citations

The Time Course of Loss of Dopaminergic Neurons and the Gliotic Reaction Surrounding Grafts of Embryonic Mesencephalon to the Striatum

1996 • 207 citations

Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model

1994 • 178 citations

Transforming growth factor-β1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease

1995 • 162 citations

Basic fibroblast growth factor promotes the survival of embryonic ventral mesencephalic dopaminergic neurons—II. Effects on nigral transplantsin vivo

1993 • 154 citations

TGFβ1 and TGFβ2 Concentrations Are Elevated in Parkinson's Disease in Ventricular Cerebrospinal Fluid

1996 • 151 citations

Synaptic input and local output of dopaminergic neurons in grafts that functionally reinnervate the host neostriatum

1987 • 143 citations

Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and human.

1991 • 139 citations

Implants of Polymer-Encapsulated Genetically Modified Cells Releasing Glial Cell Line-Derived Neurotrophic Factor Improve Survival, Growth, and Function of Fetal Dopaminergic Grafts

1998 • 121 citations

Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA

1995 • 117 citations

Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys

1995 • 116 citations

Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum

1997 • 106 citations

A Glial Cell Line-Derived Neurotrophic Factor-Secreting Clone of the Schwann Cell Line SCTM41 Enhances Survival and Fiber Outgrowth from Embryonic Nigral Neurons Grafted to the Striatum and to the Lesioned Substantia Nigra

1999 • 102 citations

Basic FGF‐like immunoreactivity in the developing and adult rat brainstem

1991 • 102 citations

NGF released from a polymer matrix prevents loss of ChAT expression in basal forebrain neurons following a fimbria-fornix lesion

1990 • 101 citations

Transforming growth factor-β promotes survival of midbrain dopaminergic neurons and protects them against N-methyl-4-phenylpyridinium ion toxicity

1994 • 99 citations

Epidermal growth factor (EGF), transforming growth factor‐α (TGF‐α), and basic fibroblast growth factor (bFGF) differentially influence neural precursor cells of mouse embryonic mesencephalon

1995 • 88 citations

Intrastriatal grafting of dopamine-containing neuronal cell suspensions: Effects of mixing with target or non-target cells

1986 • 88 citations

Cytoarchitectonics of substantia nigra grafts: A light and electron microscopic study of immunocytochemically identified dopaminergic neurons and fibrous astrocytes

1985 • 83 citations

Basic FGF is present in dopaminergic neurons of the ventral midbrain of the rat

1991 • 80 citations

Effects of Glial Cell Line-Derived Neurotrophic Factor on Developing and Mature Ventral Mesencephalic Grafts in Oculo

1995 • 79 citations

Embryonic mesencephalic and striatal co-grafts: Development of grafted dopamine neurons and functional recovery

1990 • 51 citations

Tirilazad Mesylate Increases Dopaminergic Neuronal Survival in thein OculoGrafting Model

1997 • 48 citations

GDNF Increases the Density of Cells Containing Calbindin but Not of Cells Containing Calretinin in Cultured Rat and Human Fetal Nigral Tissue

1999 • 42 citations

Expression of EGF receptor mRNA in rat nigrostriatal system

1994 • 41 citations

Tempting Fate and Commitment in the Developing Forebrain

1996 • 40 citations

Epidermal growth factor-induced survival and proliferation of neuronal precursor cells from embryonic rat mesencephalon

1992 • 38 citations

Embryonic substantia nigra grafts innervate embryonic striatal co-grafts in preference to mature host striatum

1987 • 36 citations

Enhanced Efficacy of Nigral-Striatal Cotransplants in Bilaterally Dopamine-Depleted Rats: An Anatomical and Behavioral Analysis

1994 • 34 citations

Fibroblast growth factors enhance dopamine fiber formation from nigral grafts

1993 • 32 citations

Can Graft-Derived Neurotrophic Activity Be Used to Direct Axonal Outgrowth of Grafted Dopamine Neurons for Circuit Reconstruction in Primates?

1993 • 23 citations

Reduced ageing effects of striatal neuronal discharge rate by aged ventral mesencephalic grafts

1996 • 23 citations

The age of striatum determines the pattern and extent of dopaminergic innervation: A nigrostriatal double graft study

1997 • 22 citations

Generation of Primary Peptide-Specific CD8 Cytotoxic T-Lymphocytes In Vitro Using Allogeneic Dendritic Cells

1998 • 18 citations

Lazaroid-enhanced survival of grafted dopamine neurons does not increase target innervation

1998 • 17 citations

Addition of lateral ganglionic eminence to rat mesencephalic grafts affects fiber outgrowth but does not enhance function

1997 • 15 citations

Morphological and Functional Evidence for Enhanced Growth and Potassium-Evoked Dopamine Release in Striatal Grafts Innervated with a Patchy Growth Pattern. An In Oculo Nigrostriatal Cograft Study

1998 • 5 citations

Implantable bioartificial hybrids for targeted therapy in the central nervous system

1997 • 4 citations