Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

1986 • 6,585 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.bul.NO (nitric oxide) through a radical reaction

1993 • 569 citations

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo

1992 • 548 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Nitric oxide synthase activity in human gynecological cancer.

1994 • 428 citations

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.

1994 • 409 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor

1994 • 222 citations

Production of angiogenic activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism.

1994 • 205 citations

Nitric oxide involvement in tumor-induced immunosuppression.

1994 • 171 citations

Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue

1988 • 157 citations

Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer.

1988 • 127 citations

Increased Vascular Permeability in Organs Mediated by the Systemic Administration of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 in Mice

1988 • 115 citations

Kinin‐generating Cascade in Advanced Cancer Patients and in vitro Study

1991 • 103 citations

Severity of neurological signs and degree of inflammatory lesions in the brains of rats with Borna disease correlate with the induction of nitric oxide synthase

1993 • 99 citations

Multiple functions of nitric oxide in pathophysiology and microbiology: analysis by a new nitric oxide scavenger

1994 • 93 citations

Induction of iron-derived EPR signals in murine cancers by nitric oxide. Evidence for multiple intracellular targets.

1994 • 90 citations

Iron potentiates bacterial lipopolysaccharide-induced nitric oxide formation in animal organs

1993 • 55 citations

In VivoElectron Paramagnetic Resonance Imaging of NO-Bound Iron Complex in a Rat Head

1995 • 38 citations

The Role of Nitric Oxide in Physiology and Pathophysiology

1995 • 23 citations

A New Nitric Oxide Scavenger, Imidazolineoxyl N-Oxide Derivative, and Its Effects in Pathophysiology and Microbiology

1995 • 22 citations

The Birth of Endothelium: Journal of Endothelial Cell Research

1993 • 3 citations

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