Structural origins of constitutive activation in rhodopsin: Role of the K296/E113 salt bridge

Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor

2000 • 5,539 citations

Requirement of Rigid-Body Motion of Transmembrane Helices for Light Activation of Rhodopsin

1996 • 1,159 citations

Identifying conformational changes with site-directed spin labeling.

2000 • 782 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

Functional role of internal water molecules in rhodopsin revealed by x-ray crystallography

2002 • 662 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)^,

2001 • 598 citations

Recent advances in site-directed spin labeling of proteins

1998 • 543 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.

1987 • 444 citations

Watching proteins move using site-directed spin labeling

1996 • 413 citations

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F

1996 • 389 citations

Investigation of structure and dynamics in membrane proteins using site-directed spin labeling

1994 • 383 citations

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

1994 • 373 citations

Rhodopsin structure, dynamics, and activation: A perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking

2003 • 354 citations

Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness

1993 • 323 citations

Technological advances in site-directed spin labeling of proteins

2013 • 292 citations

Characterization of bovine rod outer segment G-protein.

1982 • 281 citations

Low resolution structure of bovine rhodopsin determined by electron cryo-microscopy

1995 • 278 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

Structural Features and Light-Dependent Changes in the Cytoplasmic Interhelical E−F Loop Region of Rhodopsin: A Site-Directed Spin-Labeling Study

1996 • 259 citations

Determinants of visual pigment absorbance: role of charged amino acids in the putative transmembrane segments

1990 • 228 citations

Constitutive activation of opsin: Influence of charge at position 134 and size at position 296

1993 • 218 citations

Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296

1992 • 169 citations

Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group

1993 • 166 citations

Autosomal dominant retinitis pigmentosa: Four new mutations in rhodopsin, one of them in the retinal attachment site

1991 • 166 citations

Mapping Light-Dependent Structural Changes in the Cytoplasmic Loop Connecting Helixes C and D in Rhodopsin: A Site-Directed Spin Labeling Study

1995 • 160 citations

Constitutive Activation of Opsin by Mutation of Methionine 257 on Transmembrane Helix 6

1998 • 141 citations

Formation of the meta II photointermediate is accompanied by conformational changes in the cytoplasmic surface of rhodopsin

1993 • 120 citations

Activating Mutations of Rhodopsin and Other G Protein-Coupled Receptors

1996 • 113 citations

Modulation of GDP Release from Transducin by the Conserved Glu134-Arg135 Sequence in Rhodopsin

1996 • 105 citations

Structure and function in rhodopsin: Rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state

1997 • 89 citations

Structure and Function in Rhodopsin. Single Cysteine Substitution Mutants in the Cytoplasmic Interhelical E−F Loop Region Show Position-Specific Effects in Transducin Activation

1996 • 84 citations

Opsin activation as a cause of congenital night blindness

2003 • 67 citations

Characterization of the Mutant Visual Pigment Responsible for Congenital Night Blindness: A Biochemical and Fourier-Transform Infrared Spectroscopy Study

1996 • 41 citations

Active site-directed inactivation of constitutively active mutants of rhodopsin.

1994 • 24 citations

Probing the Dark State Tertiary Structure in the Cytoplasmic Domain of Rhodopsin: Proximities between Amino Acids Deduced from Spontaneous Disulfide Bond Formation between Cysteine Pairs Engineered in Cytoplasmic Loops 1, 3, and 4

2001 • 23 citations