Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.

Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells

1987 • 2,368 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

The gradient morphogen bicoid is a concentration-dependent transcriptional activator

1989 • 655 citations

The new mouse genetics: Altering the genome by gene targeting

1989 • 608 citations

Vectors for Drosophila P-element-mediated transformation and tissue culture transfection

1988 • 547 citations

Fluorescence-activated cell analysis and sorting of viable mammalian cells based on beta-D-galactosidase activity after transduction of Escherichia coli lacZ.

1988 • 487 citations

A whole-mount immunocytochemical analysis of the expression of the intermediate filament protein vimentin in Xenopus

1989 • 441 citations

Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene.

1984 • 435 citations

Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen

1989 • 432 citations

Regulation and function of the Drosophila segmentation gene fushi tarazu

1987 • 415 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Tumorigenesis by mouse mammary tumor virus: Evidence for a common region for provirus integration in mammary tumors

1983 • 327 citations

The mec-3 gene of Caenorhabditis elegans requires its own product for maintained expression and is expressed in three neuronal cell types.

1989 • 321 citations

Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell ‘culture shock’ glycoprotein of Mr 43,000.

1986 • 315 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues

1989 • 273 citations

HOMOLOGOUS RECOMBINATION IN MAMMALIAN CELLS

1989 • 262 citations

Autoregulatory and gap gene response elements of the even-skipped promoter of Drosophila.

1989 • 254 citations

The development of cystic embryoid bodies in vitro from clonal teratocarcinoma stem cells

1977 • 223 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Spatial and temporal pattern of hsp26 expression during normal development.

1986 • 193 citations

Production of chimaeric mice containing embryonic stem (ES) cells carrying a homoeobox Hox 1.1 allele mutated by homologous recombination

1989 • 166 citations

In Situ Detection of β-Galactosidase in Lenses of Transgenic Mice with a γ-Crystallin/ lacZ Gene

1987 • 137 citations

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.

1988 • 130 citations

The homeotic gene Sex Combs Reduced of Drosophila: gene structure and embryonic expression.

1989 • 101 citations

Cut, paste, and save: New approaches to altering specific genes in mice

1989 • 92 citations

Towards a molecular-genetic analysis of mammalian development

1989 • 77 citations

Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family.

1988 • 67 citations

Detection and Characterization of the Fibroblast Growth Factor-Related Oncoprotein INT-2

1989 • 66 citations

Effect of the Molecular Nature of Mutation on the Efficiency of Intrachromosomal Gene Conversion in Mouse Cells

1987 • 46 citations