Two distinct pathways of positive selection for thymocytes

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Exclusion and inclusion of α and β T cell receptor alleles

1992 • 346 citations

CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus

1991 • 343 citations

A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein

1993 • 333 citations

Kinetics of mature T-cell development in the thymus.

1990 • 331 citations

Mice lacking major histocompatibility complex class I and class II molecules.

1993 • 259 citations

Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes.

1993 • 247 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: A new perspective on thymic commitment and selection

1995 • 207 citations

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1995 • 201 citations

Unexpectedly Complex Regulation of CD4/CD8 Coreceptor Expression Supports a Revised Model for CD4+CD8+ Thymocyte Differentiation

1996 • 199 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Thymic emigration: conveyor belts or lucky dips?

1995 • 186 citations

Development of the CD4 and CD8 lineage of T cells: instruction versus selection.

1991 • 144 citations

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

1990 • 136 citations

Intermediate steps in positive selection: differentiation of CD4+8int TCRint thymocytes into CD4-8+TCRhi thymocytes.

1995 • 129 citations

In vivo thymocyte maturation. BUdR labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model.

1986 • 124 citations

Autoradiographic analysis of lymphocyte proliferation in the thymus and in thymic lymphoma tissue.

1966 • 109 citations

Development of Mature CD8⁺Thymocytes: Selection Rather Than Instruction?

1993 • 94 citations

Phenotypic changes accompanying positive selection of CD4⁺CD8⁺ thymocytes

1992 • 64 citations

The c-kit+ Maturation Pathway in Mouse Thymic T Cell Development: Lineages and Selection

1996 • 56 citations

Expression of the mouse interleukin‐2 receptor γ chain in various cell populations of the thymus and spleen

1994 • 54 citations

Intermediate steps in thymic positive selection. Generation of CD4-8+ T cells in culture from CD4+8+, CD4int8+, and CD4+8int thymocytes with up-regulated levels of TCR-CD3.

1995 • 48 citations

Stochastic coreceptor shut-off is restricted to the CD4 lineage maturation pathway.

1995 • 46 citations

Small cortical thymocytes are subject to positive selection.

1994 • 38 citations

T cell receptor-mediated selection of functional rat CD8 T cells from defined immature thymocyte precursors in short-term suspension culture.

1991 • 30 citations