Commentary: The Role of Iron-Sulfur Clusters inin vivoHydroxyl Radical Production

Superoxide Dismutase

1969 • 12,578 citations

Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase

1974 • 9,660 citations

[1] Role of free radicals and catalytic metal ions in human disease: An overview

1990 • 5,041 citations

SUPEROXIDE RADICAL AND SUPEROXIDE DISMUTASES

1995 • 3,305 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer

1996 • 2,327 citations

Peroxynitrite-induced membrane lipid peroxidation: The cytotoxic potential of superoxide and nitric oxide

1991 • 2,215 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Biological effects of the superoxide radical

1986 • 1,446 citations

Superoxide radical inhibits catalase.

1982 • 1,274 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide Dismutase

1971 • 979 citations

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

1974 • 894 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life?

1986 • 777 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of iron chelates

1978 • 748 citations

Altered Reactivity of Superoxide Dismutase in Familial Amyotrophic Lateral Sclerosis

1996 • 718 citations

A Mechanism for the Production of Ethylene from Methional

1970 • 668 citations

The inactivation of Fe-S cluster containing hydro-lyases by superoxide.

1993 • 628 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

Oxygen and oxy‐radicals in chemistry and biology

1982 • 557 citations

Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.

1990 • 555 citations

Inactivation of glutathione peroxidase by superoxide radical

1985 • 546 citations

Ferritin and superoxide-dependent lipid peroxidation.

1985 • 532 citations

Reactions of ferrous and ferric ions with hydrogen peroxide. Part I.—The ferrous ion reaction

1951 • 510 citations

Superoxide sensitivity of the Escherichia coli aconitase.

1991 • 499 citations

Superoxide Radical and Iron Modulate Aconitase Activity in Mammalian Cells

1995 • 467 citations

Lethal oxidative damage and mutagenesis are generated by iron in delta fur mutants of Escherichia coli: protective role of superoxide dismutase

1995 • 438 citations

Bactericidal activity of peroxynitrite

1992 • 436 citations

The role of O2.− in the production of HO.: in vitro and in vivo

1994 • 421 citations

The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen

1969 • 419 citations

Assay of metabolic superoxide production in Escherichia coli.

1991 • 405 citations

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

1989 • 381 citations

The role of iron in the activation-inactivation of aconitase.

1983 • 379 citations

REGULATION OF BACTERIAL OXIDATIVE STRESS GENES

1991 • 377 citations

Superoxide dismutase: The first twenty years (1968–1988)

1988 • 375 citations

Ferritin as a source of iron for oxidative damage

1992 • 359 citations

Superoxide as an intracellular radical sink

1993 • 356 citations

soxR, a locus governing a superoxide response regulon in Escherichia coli K-12

1990 • 341 citations

Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical.

1992 • 336 citations

An iron-sulfur center essential for transcriptional activation by the redox-sensing SoxR protein.

1994 • 331 citations

Pulse radiolytic studies of the reaction of perhydroxyl/superoxide O2- with iron(II)/iron(III) ions. The reactivity of HO2/O2- with ferric ions and its implication on the occurrence of the Haber-Weiss reaction

1985 • 329 citations

Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase.

1986 • 314 citations

Activation by nitric oxide of an oxidative-stress response that defends Escherichia coli against activated macrophages.

1993 • 310 citations

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical.

1981 • 280 citations

Aconitase, a two‐faced protein: enzyme and iron regulatory factor ^{1 2}

1993 • 269 citations

The Reaction of Superoxide with Reduced Glutathione

1994 • 264 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase

1991 • 259 citations

Superoxide radicals and hydrogen peroxide formation in mitochondria from normal and neoplastic tissues

1975 • 250 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Chemiluminescence and peroxidation

1975 • 249 citations

Biological and clinical aspects of superoxide and superoxide dismutase

1980 • 245 citations

alpha, beta-Dihydroxyisovalerate dehydratase. A superoxide-sensitive enzyme.

1987 • 239 citations

Superoxide and the production of oxidative DNA damage

1995 • 231 citations

Fumarase C, the stable fumarase of Escherichia coli, is controlled by the soxRS regulon.

1992 • 231 citations

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

1994 • 221 citations

Reactions of Ferrous and Ferric Ions with Hydrogen Peroxide

1949 • 215 citations

Superoxide‐dependent formation of hydroxyl radicals in the presence of thiol compounds

1982 • 214 citations

Superoxide anion and endothelial regulation of arterial tone

1996 • 211 citations

Binuclear [2Fe-2S] Clusters in the Escherichia coli SoxR Protein and Role of the Metal Centers in Transcription

1995 • 206 citations

Two-stage induction of the soxRS (superoxide response) regulon of Escherichia coli

1992 • 192 citations

Superoxide-dependent and -independent mechanisms of iron mobilization from ferritin by xanthine oxidase. Implications for oxygen-free-radical-induced tissue destruction during ischaemia and inflammation

1986 • 187 citations

Reduced Nicotinamide Adenine Dinucleotide Phosphate-Sulfite Reductase of Enterobacteria

1974 • 169 citations

2 Flavodoxins and Electron-Transferring Flavoproteins

1975 • 163 citations

Biotin Synthase: Purification, Characterization as a [2Fe-2S]Cluster Protein, and in vitro Activity of the Escherichia coli bioB Gene Product

1994 • 150 citations

An iron-sulfur center and a free radical in the active anaerobic ribonucleotide reductase of Escherichia coli.

1993 • 147 citations

Two genetically-distinct and differentially-regulated aconitases (AcnA and AcnB) in Escherichia coli

1994 • 147 citations

Oxidative Stress Induces Activation of a Cytosolic Protein Responsible for Control of Iron Uptake

1995 • 146 citations

The role and properties of the iron-sulfur cluster in Escherichia coli dihydroxy-acid dehydratase

1993 • 144 citations

NADPH: ferredoxin oxidoreductase acts as a paraquatdiaphorase and is a member of the soxRS regulon.

1994 • 142 citations

nifU Gene Product from Azotobacter vinelandii Is a Homodimer That Contains Two Identical [2Fe-2S] Clusters

1994 • 139 citations

Routes of Flavodoxin and Ferredoxin Reduction in Escherichia coli

1982 • 137 citations

A Metabolic Enzyme That Rapidly Produces Superoxide, Fumarate Reductase of Escherichia coli

1995 • 127 citations

Biosynthesis of branched chain amino acids

1991 • 117 citations

Ferric reductases or flavin reductases?

1994 • 110 citations

The inactivation of dihydroxy-acid dehydratase in Escherichia coli treated with hyperbaric oxygen occurs because of the destruction of its Fe-S cluster, but the enzyme remains in the cell in a form that can be reactivated.

1993 • 110 citations

Fumarase A from Escherichia coli: purification and characterization as an iron-sulfur cluster containing enzyme

1992 • 110 citations

A double life: cytosolic aconitase as a regulatory RNA binding protein.

1993 • 108 citations

Flavodoxin Is Required for the Activation of the Anaerobic Ribonucleotide Reductase

1993 • 103 citations

Overproduction and Physical Characterization of SoxR, a [2Fe-2S] Protein That Governs an Oxidative Response Regulon in Escherichia coli

1995 • 102 citations

Regulation of sod genes in Escherichia coli: relevance to superoxide dismutase function

1991 • 99 citations

Vanadate-stimulated oxidation of NAD(P)H in the presence of biological membranes and other sources of O2−

1990 • 92 citations

Superoxide‐dependent formation of hydroxyl radicals from NADH and NADPH in the presence of iron salts

1982 • 87 citations

The NAD(P)H:flavin oxidoreductase from Escherichia coli as a source of superoxide radicals.

1994 • 81 citations

Flavodoxin is Required for Conversion of Dethiobiotin to Biotin in Escherichia coli

1994 • 79 citations

Presence of iron catalytic for free radical reactions in patients undergoing chemotherapy: implications for therapeutic management

1995 • 72 citations

Modulation of the Fumarases of Escherichia coli in Response to Oxidative Stress

1993 • 71 citations

In vivo reactivation of catechol 2,3-dioxygenase mediated by a chloroplast-type ferredoxin: a bacterial strategy to expand the substrate specificity of aromatic degradative pathways.

1993 • 70 citations

Suppression of oxidative envelope damage by pseudoreversion of a superoxide dismutase-deficient mutant of Escherichia coli

1992 • 63 citations

Enzyme-catalyzed free radical reactions with nicotinamide-adenine nucleotides

1973 • 62 citations

The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin

1988 • 61 citations

Dihydroxyacid dehydratase: The site of hyperbaric oxygen poisoning in branch-chain amino acid biosynthesis

1978 • 57 citations

Effect of Glutathione on Aconitase in Escherichia coli

1993 • 54 citations

Intracellular generation of superoxide as a by-product of Vibrio harveyi luciferase expressed in Escherichia coli

1994 • 54 citations

A Superoxide-Dismutase Mimic Protects SodA SodB Escherichia coli against Aerobic Heating and Stationary-Phase Death

1995 • 53 citations

Quinolinate synthetase: The oxygen-sensitive site of de novo NAD(P)+ biosynthesis

1991 • 50 citations

Flavine-protein interactions in flavoenzymes. Thermodynamics and kinetics of reduction of Azotobacter flavodoxin

1972 • 50 citations

Interruption of the ferredoxin (flavodoxin) NADP+ oxidoreductase gene of Escherichia coli does not affect anaerobic growth but increases sensitivity to paraquat

1995 • 49 citations

The mobile ferrous iron pool in Escherichia coli is bound to a phosphorylated sugar derivative

1995 • 48 citations

Initial Kinetic and Mechanistic Characterization of Escherichia coli Fumarase A

1994 • 47 citations

Escherichia coli genes involved in cell survival during dormancy: Role of oxidative stress

1992 • 45 citations

Electron spin resonance kinetic studies of the oxidation of vanadium(IV) by hydrogen peroxide

1971 • 45 citations

What is Unique About Superoxide Toxicity as Compared to Other Biological Reductants? — A Hypothesis

1988 • 43 citations

The roles of O2−, HO., and secondarily derived radicals in oxidation reactions catalyzed by vanadium salts

1991 • 42 citations

Dihydroxy-acid Dehydratase, a (4Fe-4S) Cluster-Containing Enzyme in Escherichia coli: Effects of Intracellular Superoxide Dismutase on Its Inactivation by Oxidant Stress

1995 • 39 citations

Oxygen and redox-active drugs: Shared toxicity sites

1983 • 36 citations

Singlet oxygen and superoxide dismutase (cuprein)

1975 • 35 citations

A pulse radiolytic study on the reaction of hydroxyl and superoxide radicals with yeast Cu(I)-thionein

1993 • 32 citations

Regulation of bacterial gene expression in response to oxidative stress

1994 • 32 citations

Induction of manganese-containing superoxide dismutase in anaerobic Escherichia coli by diamide and 1,10-phenanthroline: sites of transcriptional regulation.

1993 • 32 citations

Paraquat diaphorases in Escherichia coli

1994 • 29 citations

Mutagenesis in Escherichia coli K-12 mutants defective in superoxide dismutase or catalase

1993 • 29 citations

NADPH inhibits transcription of the Escherichia coli manganese superoxide dismutase gene (sodA) in vitro

1993 • 29 citations

Superoxide-dependent production of hydroxyl radicals in the presence of iron salts

1982 • 25 citations

Effects of overproduction of superoxide dismutases in Escherichia coli on inhibition of growth and on induction of glucose-6-phosphate dehydrogenase by paraquat

1992 • 24 citations

On the Question of Superoxide Toxicity and the Biological Function of Superoxide Dismutases

1982 • 24 citations

Mathematical model supporting the superoxide theory of oxygen toxicity

1994 • 20 citations

The NADPH: Sulfite Reductase of Escherichia coli is a Paraquat Reductase

1994 • 16 citations

Relationship between growth of Escherichia coli and susceptibility to the lethal effect of paraquat

1990 • 15 citations

Overproduction of superoxide dismutase does not protect Escherichia coli from stringency-induced growth inhibition by 1mM paraquat.

1990 • 13 citations

Nitric Oxide and Radicals in the Pulmonary Vasculature

1997 • 12 citations

Functional Complementation of the MvrA Mutation of Escherichia coli by Plant Ferredoxin-NADP+ Oxidoreductase

1995 • 12 citations

The effects of paraquat on Escherichia coli:Distinction between bacteriostasis and lethality

1986 • 11 citations

Interaction of a redox‐sensitive DNA‐binding factor with the 5′‐flanking region of the micF gene in Escherichia coli

1993 • 6 citations

Reply to commentary by Helmut Beinert and Patricia Kiley

1996 • 1 citations