GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.

1986 • 2,118 citations

Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 • 1,150 citations

rab5 controls early endosome fusion in vitro

1991 • 1,090 citations

Molecular dissection of the secretory pathway

1992 • 985 citations

A ras-like protein is required for a post-Golgi event in yeast secretion

1987 • 894 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway

1990 • 721 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein

1991 • 604 citations

A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast

1988 • 592 citations

Sequence dependence of protein isoprenylation

1991 • 580 citations

The ras protein family: evolutionary tree and role of conserved amino acids

1991 • 573 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Small GTP-Binding Proteins

1992 • 526 citations

Pre- and post-golgi vacuoles operate in the transport of semliki forest virus membrane glycoproteins to the cell surface

1984 • 523 citations

Involvement of GTP-binding “G” proteins in transport through the Golgi stack

1987 • 495 citations

Identification, by a monoclonal antibody, of a 53-kD protein associated with a tubulo-vesicular compartment at the cis-side of the Golgi apparatus.

1988 • 488 citations

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

1990 • 486 citations

A novel GTP-binding protein, Sar1p, is involved in transport from the endoplasmic reticulum to the Golgi apparatus.

1989 • 443 citations

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

1987 • 403 citations

Hypervariable C-termmal domain of rab proteins acts as a targeting signal

1991 • 394 citations

Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.

1991 • 391 citations

A new cationic liposome reagent mediating nearly quantitative transfection of animal cells.

1991 • 390 citations

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

1989 • 387 citations

Small GTP-binding proteins in vesicular transport

1990 • 381 citations

Small GTP-binding protein associated with Golgi cisternae

1990 • 356 citations

Calcium and GTP: essential components in vesicular trafficking between the endoplasmic reticulum and Golgi apparatus.

1989 • 351 citations

Semi-intact cells permeable to macromolecules: Use in reconstitution of protein transport from the endoplasmic reticulum to the Golgi complex

1987 • 321 citations

Distinct biochemical requirements for the budding, targeting, and fusion of ER-derived transport vesicles.

1991 • 318 citations

Distribution of the intermediate elements operating in ER to Golgi transport

1991 • 315 citations

Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic.

1989 • 314 citations

The structure of Ras protein: a model for a universal molecular switch

1991 • 310 citations

The small GTP-binding protein rab4 is associated with early endosomes.

1991 • 286 citations

The ras-related YPT1 gene product in yeast: A GTP-binding protein that might be involved in microtubule organization

1986 • 281 citations

Study of a temperature-sensitive mutant of the ras-related YPT1 gene product in yeast suggests a role in the regulation of intracellular calcium

1988 • 243 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

The GTP-binding protein Ypt1 is required for transport in vitro: the Golgi apparatus is defective in ypt1 mutants.

1989 • 234 citations

ADP-ribosylation factor is required for vesicular trafficking between the endoplasmic reticulum and the cis-Golgi compartment.

1992 • 213 citations

Molecular Cloning of YPT1/SEC4-Related cDNAs from an Epithelial Cell Line

1990 • 210 citations

Association of the GTP-binding protein Rab3A with bovine adrenal chromaffin granules.

1990 • 195 citations

ras and GAP—Who's controlling whom?

1990 • 185 citations

GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction.

1990 • 177 citations

Isoprenoid modification of rab proteins terminating in CC or CXC motifs.

1991 • 177 citations

Chemical and immunological characterization of the 21-kDa ADP-ribosylation factor of adenylate cyclase.

1988 • 175 citations

Small GTP-binding proteins and their role in transport

1991 • 164 citations

Envelope Proteins of Vesicular Stomatitis Virus: Effect of Temperature-Sensitive Mutations in Complementation Groups III and V

1974 • 155 citations

Sec12p-dependent membrane binding of the small GTP-binding protein Sar1p promotes formation of transport vesicles from the ER.

1991 • 143 citations

ATP-coupled transport of vesicular stomatitis virus G protein between the endoplasmic reticulum and the Golgi.

1986 • 141 citations

The ras-related mouse ypt1 protein can functionally replace the YPT1 gene product in yeast.

1989 • 136 citations

Synthetic peptides of the Rab effector domain inhibit vesicular transport through the secretory pathway.

1990 • 134 citations

Isoprenoid modification and plasma membrane association: critical factors for ras oncogenicity.

1991 • 126 citations

Multiple GTP-binding proteins regulate vesicular transport from the ER to Golgi membranes.

1992 • 123 citations

Derepression of a novel class of vaccinia virus genes upon DNA replication.

1988 • 117 citations

Cytoplasmic transcription system encoded by vaccinia virus

1991 • 114 citations

rab GTP-binding proteins implicated in vesicular transport are isoprenylated in vitro at cysteines within a novel carboxyl-terminal motif

1991 • 102 citations

Binding and hydrolysis of guanine nucleotides by Sec4p, a yeast protein involved in the regulation of vesicular traffic.

1990 • 100 citations

The residues of Ras and Rap proteins that determine their GAP specificities

1991 • 100 citations

Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases.

1991 • 92 citations

Mutational analysis of the putative effector domain of the GTP-binding Ypt1 protein in yeast suggests specific regulation by a novel GAP activity.

1991 • 91 citations

Reconstitution of GTP-binding Sar1 protein function in ER to Golgi transport.

1991 • 84 citations

Ras p21: effects and regulation

1991 • 78 citations

A mammalian inhibitory GDP/GTP exchange protein (GDP dissociation inhibitor) for smg p25A is active on the yeast SEC4 protein.

1991 • 78 citations

A novel prenyltransferase for a small GTP-binding protein having a C-terminal Cys-Ala-Cys structure.

1991 • 69 citations

Sequential transport of protein between the endoplasmic reticulum and successive Golgi compartments in semi-intact cells

1991 • 67 citations

Transport of the vesicular stomatitis glycoprotein to trans Golgi membranes in a cell-free system.

1987 • 65 citations

Small GTP-binding proteins of the ras family: a conserved functional mechanism?

1991 • 65 citations

Proteins involved in vesicular transport and membrane fusion

1991 • 47 citations

Molecular machinery required for protein transport from the endoplasmic reticulum to the golgi complex

1990 • 41 citations

Vaccinia Virus Expression Vectorsa

1989 • 30 citations

Vaccinia Virus Vectors

1992 • 26 citations

Alternate mechanisms of ras activation are complementary and favor and formation of ras-GTP.

1992 • 22 citations

A Mammalian Inhibitory GDP/GTP Exchange Protein (GDP Dissociation Inhibitor) for smg p25A Is Active on the Yeast SEC4 Protein

1991 • 17 citations

Regulation of intracellular calcium

1984 • 11 citations

Deleted Work

1955 • 0 citations