Induction of cytochrome P450-dependent monooxygenase activities in rat hepatoma H-4-IIE cells in culture by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds: Mechanistic studies using radiolabeled congeners

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

1982 • 2,512 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions

1980 • 827 citations

Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action

1984 • 793 citations

Comparative Toxicology and Mechanism of Action of Polychlorinated Dibenzo-P-Dioxins and Dibenzofurans

1986 • 707 citations

The classification of drugs and drug receptors in isolated tissues.

1984 • 474 citations

Nuclear mechanisms of estrogen action. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing.

1978 • 348 citations

STUDIES ON THE MECHANISM OF ACTION OF THE CHLORINATED DIBENZO‐p‐DIOXINS AND RELATED COMPOUNDS*

1979 • 336 citations

Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements

1987 • 323 citations

The Regulation of Cytochrome P-450 Gene Expression

1986 • 283 citations

Control of Cytochrome P ₁ -450 Gene Expression by Dioxin

1985 • 272 citations

The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1987 • 251 citations

Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines.

1980 • 227 citations

The Ah locus: Correlation of intranuclear appearance of inducer-receptor complex with induction of cytochrome P1-450 mRNA

1982 • 184 citations

Autoregulation plus upstream positive and negative control regions associated with transcriptional activation of the mouse P₁450 gene

1985 • 174 citations

Polychlorinated dibenzofurans (PCDFs): Effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity

1984 • 150 citations

Polychlorinated dibenzo-p-dioxins: Quantitative in vitro and in vivo structure-activity relationships

1986 • 139 citations

Polychlorinated dibenzofurans (PCDFs): Correlation between in vivo and in vitro structure-activity relationships

1985 • 139 citations

Cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Evidence for a homologous nature among various mammalian species.

1984 • 134 citations

Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.

1986 • 83 citations

The receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse hepatoma cell line Hepa 1c1c7. A comparison with the glucocorticoid receptor and the mouse and rat hepatic dioxin receptors.

1987 • 79 citations

Nuclear estrogen receptors. Effect of inhibitors on processing and steady state levels.

1980 • 78 citations

Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.

1988 • 78 citations

6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities.

1988 • 73 citations

Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Comparative studies in mammalian and nonmammalian species

1986 • 70 citations

Heterogeneity of the rat hepatic Ah receptor and evidence for transformation in vitro and in vivo.

1987 • 67 citations

Dioxin-Inducible Enhancer Region Upstream from the Mouse P₁450 Gene and Interaction with a Heterologous SV40 Promoter

1986 • 53 citations

Diethylstilbestrol metabolites and analogs. Biochemical probes for differential stimulation of uterine estrogen responses.

1985 • 40 citations

Synthesis and aryl hydrocarbon receptor binding properties of radiolabeled polychlorinated dibenzofuran congeners

1987 • 39 citations

Synthesis and characterization of twenty-two purified polychlorinated dibenzofuran congeners

1984 • 39 citations

Ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver, lung, and thymus

1984 • 37 citations

Estrogen receptor stereochemistry: Receptor binding and hormonal responses

1987 • 33 citations

Electrophilic bromination of dibenzofuran

1987 • 16 citations