Polychlorinated dibenzofurans as 2,3,7,8-tcdd antagonists: In vitro inhibition of monooxygenase enzyme induction

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

A rapid method for assaying the metabolism of 7-ethoxyresorufin by microsomal subcellular fractions

1980 • 827 citations

Polychlorinated Biphenyls (PCBs) and Polybrominated Biphenyls (PBBs): Biochemistry, Toxicology, and Mechanism of Action

1984 • 793 citations

Regulatory gene product of the Ah locus. Characterization of the cytosolic inducer-receptor complex and evidence for its nuclear translocation.

1979 • 401 citations

2,3,7,8,-Tetrachlorodibenzo-p-dioxin: segregation of toxocity with the Ah locus.

1980 • 394 citations

STUDIES ON THE MECHANISM OF ACTION OF THE CHLORINATED DIBENZO‐p‐DIOXINS AND RELATED COMPOUNDS*

1979 • 336 citations

Control of Cytochrome P ₁ -450 Gene Expression by Dioxin

1985 • 272 citations

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

1975 • 245 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Evidence for a Receptor Mutation in Genetically Non-responsive Mice

1975 • 238 citations

Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines.

1980 • 227 citations

PCB isomers and congeners: Induction of aryl hydrocarbon hydroxylase and ethoxyresorufin O-deethylase enzyme activities in rat hepatoma cells

1982 • 184 citations

Regulation of cytochrome P1-450 gene transcription by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells.

1984 • 166 citations

Polychlorinated dibenzofurans (PCDFs): Effects of structure on binding to the 2,3,7,8-TCDD cytosolic receptor protein, AHH induction and toxicity

1984 • 150 citations

Immunosuppressive effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in strains of mice with different susceptibility to induction of aryl hydrocarbon hydroxylase

1983 • 143 citations

Polychlorinated dibenzofurans (PCDFs): Correlation between in vivo and in vitro structure-activity relationships

1985 • 139 citations

Cellular and genetic basis for suppression of cytotoxic T cell generation by haloaromatic hydrocarbons

1983 • 138 citations

Induction of Enzyme Activity in Cell Culture: A Rapid Screen for Detection of Planar Poly chlorinated Organic Compounds

1979 • 112 citations

Dependence of the porphyrogenic effect of 2,3,7,8-tetrachlorodibenzo(p)dioxin upon inheritance of aryl hydrocarbon hydroxylase responsiveness

1980 • 104 citations

Sensitivity to suppression of cytotoxic T cell generation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on the Ah genotype of the murine host

1984 • 104 citations

Cytosolic and Nuclear Binding of 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin to the AhReceptor in Extra‐Hepatic Tissues of Rats and Mice

1982 • 103 citations

Binding of 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin to a Common Ah Receptor Site in Mouse and Rat Hepatic Cytosols

1982 • 90 citations

Binding of benzo(a)pyrene and dibenz(a,h)anthracene to the Ah receptor in mouse and rat hepatic cytosols.

1984 • 77 citations

Induction of Aryl Hydrocarbon Hydroxylase Activity in Various Cell Cultures by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1975 • 75 citations

The Ah receptor: Binding specificity only for foreign chemicals?

1984 • 65 citations

In vitro AHH induction by polychlorinated biphenyl and dibenzofuran mixtures: Additive effects

1985 • 64 citations

Induction of 7-ethoxycoumarin O-deethylase activity in cultured human epithelial cells by 2,3,7,8-tetrachlorodibenzo-P-dioxin (TCDD): Evidence for TCDD receptor

1983 • 47 citations

Biochemical and genetic analysis of variant mouse hepatoma cells which overtranscribe the cytochrome P1-450 gene in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1984 • 44 citations

A comparative study of polychlorinated dibenzofurans, polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin on aryl hydrocarbon hydroxylase inducing potency in rats

1983 • 41 citations

Effects of substituents on the cytosolic receptor-binding avidities and aryl hydrocarbon hydroxylase induction potencies of 7-substituted 2,3-dichlorodibenzo-p-dioxins. A quantitative structure-activity relationship analysis.

1985 • 40 citations

Synthesis and characterization of twenty-two purified polychlorinated dibenzofuran congeners

1984 • 39 citations

The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls

1983 • 38 citations

Quantitation of hepatic cytochrome P1-450 mRNA with the use of a cloned DNA probe. Effects of various P-450 inducers in C57BL/6N and DBA/2N mice.

1982 • 37 citations

Sources and fate of polychlorinated dibenzodioxins, dibenzofurans and related compounds in human environments.

1985 • 34 citations

The Effect of Acute Administration of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Humoral Antibody Production and Cell-Mediated Activities in Mice

1980 • 32 citations

Screening of Fresh Water Fish Extracts for Enzyme-Inducing Substances by an Aryl Hydrocarbon Hydroxylase Induction Bioassay Technique

1983 • 27 citations

Sources and Fate of Polychlorinated Dibenzodioxins, Dibenzofurans and Related Compounds in Human Environments

1985 • 25 citations

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