Brain γ-Aminobutyric Acid Abnormality in Tardive Dyskinesia

(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

1980 • 1,091 citations

Tardive Dyskinesia

1982 • 660 citations

The distribution of cholecystokinin immunoreactivity in the central nervous system of the rat as determined by radioimmunoassay

1981 • 545 citations

The influence of fatigue on health-related quality of life in patients with Parkinson's disease

2003 • 439 citations

Evidence for a gabaergic projection from the substantia nigra to the ventromedial thalamus and to the superior colliculus of the rat

1979 • 397 citations

Simultaneous Determination of 3,4‐Dihydroxyphenylalanine, 5‐Hydroxytryptophan, Dopamine, 4‐Hydroxy‐3‐Methoxyphenylalanine, Norepinephrine, 3,4‐Dihydroxyphenylacetic Acid, Homovanillic Acid, Serotonin, and 5‐Hydroxyindoleacetic Acid in Rat Cerebrospinal Fluid and Brain by High‐Performance Liquid Chromatography with Electrochemical Detection

1982 • 350 citations

Spontaneous Involuntary Disorders of Movement

1982 • 338 citations

Evidence for the participation of nigrotectal γ-aminobutyrate-containing neurones in striatal and nigral-derived circling in the rat

1982 • 318 citations

On the source of gaba-containing terminals in the substantia nigra. Electron microscopic autoradiographic and biochemical studies

1973 • 286 citations

An experimental model of tardive dyskinesia

1972 • 276 citations

Immunocytochemical studies of GABAergic neurons in rat basal ganglia and their relations to other neuronal systems

1984 • 273 citations

GABA levels in CSF of patients with psychiatric disorders

1980 • 263 citations

Association with persistent neuroleptic-induced dyskinesia of regional changes in brain GABA synthesis

1984 • 252 citations

CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa

1981 • 251 citations

Dopaminergic hypersensitivity and cholinergic hypofunction in the pathophysiology of tardive dyskinesia

1974 • 245 citations

Intranigral kainic acid is evidence that nigral non-dopaminergic neurones control posture

1977 • 243 citations

EXPERIMENTAL HEMICHOREA/ HEMIBALLISMUS IN THE MONKEY

1984 • 209 citations

The nigrotectal projection: a biochemical and ultrastructural characterization

1978 • 193 citations

Inhibitory effect of gammahydroxybutyric acid and gammaaminobutyric acid on the dopamine cells in the substantia nigra

1973 • 193 citations

The Pathophysiologic Basis of Tardive Dyskinesia

1980 • 190 citations

Dynamic utilization of GABA in substantia nigra: regulation by dopamine and GABA in the striatum, and its clinical and behavioral implications

1981 • 154 citations

CONCENTRATION OF HOMOVANILLIC ACID AND 5‐HYDROXYINDOLEACETIC ACID IN THE CEREBROSPINAL FLUID AFTER TREATMENT WITH PROBENECID IN PATIENTS WITH DRUG‐INDUCED TARDIVE DYSKINESIA

1970 • 143 citations

Reduction of nigral glutamic acid decarboxylase in rats with neuroleptic-induced oral dyskinesia

1983 • 140 citations

The distribution and some morphological features of substantia nigra neurons that project to the thalamus, superior colliculus and pedunculopontine nucleus in the monkey

1982 • 138 citations

Biological substrates of schizophrenia

2009 • 128 citations

Improvement in Tardive Dyskinesia After Muscimol Therapy

1979 • 123 citations

Increased gamma-aminobutyric acid (GABA), homocarnosine and β-alanine in cerebrospinal fluid of patients treated with γ-vinyl GABA (4-amino-hex-5-enoic acid)

1981 • 119 citations

Effect of Sodium Valproate on Tardive Dyskinesia

1976 • 118 citations

Long-Term Treatment of Tardive Dyskinesia with Haloperidol and Tetrabenazine

1973 • 116 citations

The effect of chronic neuroleptic administration on cerebral dopamine receptor function

1983 • 113 citations

Muscimol: GABA agonist therapy in schizophrenia

1978 • 113 citations

Paradoxical response to dopamine agonists in tardive dyskinesia

1977 • 112 citations

Incidence of tardive dyskinesia: five-year data from a prospective study.

1984 • 112 citations

γ-Acetylenic GABA in Tardive Dyskinesia

1980 • 111 citations

Chronic blockade of dopamine receptors by antischizophrenic drugs enhances GABA binding in substantia nigra

1980 • 110 citations

Free and conjugated amino acids in human CSF: Influence of age and sex

1985 • 108 citations

Abnormal Involuntary Movements in Schizophrenia

1982 • 104 citations

Neurochemical analysis of cerebrospinal fluid

1980 • 103 citations

Turnover times of gamma-aminobutyric acid and acetylcholine in nucleus caudatus, nucleus accumbens, globus pallidus and substantia nigra: effects of repeated administration of haloperidol

1977 • 103 citations

Substantia nigra as an out-put station for striatal dopaminergic responses: Role of a GABA-mediated inhibition of pars reticulata neurons

1979 • 102 citations

In Search of Treatment for Tardive Dyskinesia: Review of the Literature*

1979 • 94 citations

A Neuroendocrine Study of Supersensitivity in Tardive Dyskinesia

1977 • 90 citations

Implications of Amphetamine-Induced Stereotyped Behavior as a Model for Tardive Dyskinesias

1972 • 84 citations

Evidence that nigral GABA mediates behavioural responses elicited by striatal dopamine receptor stimulation

1978 • 84 citations

γ-aminobutyric acidB receptors in the rat brain: Quantitative autoradiographic localization using [3H](−)-baclofen

1985 • 70 citations

Suppression by GABAergic drugs of the locomotor stimulation induced by morphine, amphetamine, and apomorphine: Evidence for both pre- and post-synaptic inhibition of catecholamine systems

1977 • 69 citations

Baclofen (Lioresal®) in the treatment of neuroleptic‐induced tardive dyskinesia

1976 • 67 citations

Stability of GABA levels in CSF under various conditions of storage

1980 • 67 citations

Effect of baclofen on tardive dyskinesia

1978 • 65 citations

Depression as a risk factor in tardive dyskinesia.

1982 • 60 citations

The pharmacology of Amanita muscaria.

1967 • 55 citations

Intranigral gaba antagonists produce dopamine-independence biting in rats

1980 • 55 citations

Behavioral supersensitivity to apomorphine and amphetamine after chronic high dose haloperidol treatment.

1975 • 52 citations

Evidence that the nigrotegmental GABAergic projection mediates stereotypy induced by apomorphine and intranigral muscimol

1983 • 52 citations

Substantia nigra as a station that not only transmits, but also transforms, incoming signals for its behavioural expression: Striatal dopamine and GABA-mediated responses of pars reticulata neurons

1983 • 51 citations

The Effect of Tetrahydroisoxazolopyridinol (THIP) in Tardive Dyskinesia

1982 • 49 citations

Gamma-Vinyl GABA

1985 • 47 citations

Triple-column ion-exchange physiological amino acid analysis with fluorescent detection: Baseline characterization of human cerebrospinal fluid

1984 • 43 citations

Effect of gamma-vinyl GABA in tardive dyskinesia

1983 • 42 citations

Gamma-vinyl-GABA treatment of tardive dyskinesia and other movement disorders

1985 • 42 citations

Anomalous behavioral response to imidazoleacetic acid, a GABA agonist, in animals treated chronically with haloperidol.

1980 • 39 citations

Baclofen in the treatment of tardive dyskinesia

1978 • 36 citations

GABA in the entopeduncular nucleus and the subthalamic nucleus participates in mediating dopaminergic striatal output functions

1981 • 36 citations

Strategy for the study of patients at high risk for tardive dyskinesia

1980 • 35 citations

Long-term treatment of tardive dyskinesia with presynaptically acting dopamine-depleting agents.

1983 • 33 citations

Gabaergic actions of thip in vivo and in vitro: A comparison with muscimol an GABA

1980 • 33 citations

Effect of haloperidol on glutamete decarboxylase activity in discrete brain areas of the rat

1983 • 32 citations

The locomotor-reducing effects of GABAergic drugs do not depend on the GABAA receptor

1985 • 32 citations

Efficacies of agents related to GABA, dopamine, and acetylcholine in the treatment of tardive dyskinesia [proceedings].

1978 • 32 citations

Chronic neuroleptic therapy: tolerance and GABA systems.

1977 • 30 citations

The treatment of tardive dyskinesia with baclofen

1985 • 29 citations

Sodium Valproate and Tardive Dyskinesia

1978 • 29 citations

Diazepam-induced changes in tardive dyskinesia: suggestions for a new conceptual model.

1982 • 26 citations

State-dependent tardive dyskinesia in manic-depressive illness.

1983 • 26 citations

Gamma‐vinyl GABA treatment of Huntington's disease

1984 • 26 citations

Suppression of apomorphine-induced oral stereotypy in rats by microinjection of muscimol into midbrain

1982 • 26 citations

Baclofen in the treatment of tardive dyskinesia and schizophrenia.

1978 • 25 citations

[Pharmacological and experimental psychological studies with 2 components of fly agaric (Amanita muscaria)].

1968 • 22 citations

Further Characterization of In Vitro Conditions Appropriate for GABA Determination in Human CSF: Impact of Acid Deproteinization and Freeze/Thaw

1983 • 19 citations

Pharmacological Modification of Experimental Tardive Dyskinesia

1979 • 18 citations

THIP, isoguvacine, isoguvacine oxide, and related GABA agonists.

1981 • 18 citations

State-Related Cyclical Dyskinesias in Manic-Depressive Illness

1982 • 16 citations

Gamma-Acetylenic GABA in tardive dyskinesia.

1980 • 15 citations

Autoradiographic localization of binding sites for the γ-aminobutyric acid analogues 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP)isoguvacine and baclofen on cultured neurons of rat cerebellum and spinal cord

1985 • 14 citations

Clinical Implications of Enzyme-Mediated Alterations of -Aminobutyric Acid Content in Human CSF

1981 • 13 citations

The role of GABA in dyskinesias induced by chemical stimulation of the striatum

1977 • 13 citations

GABA: AN ESSENTIAL MODERATOR AND MEDIATOR IN THE BASAL GANGLIA SYSTEM OF DOPAMINE RELATED FUNCTIONS.

2009 • 12 citations

Geriatric psychopharmacology: clinical evaluation of brain function in the aged.

1978 • 4 citations

Combination Treatment of Choreiform and Dyskinetic Syndromes with Tetrabenazine and Pimozide

1980 • 4 citations