Dopaminergic supersensitivity after neuroleptics: Time-course and specificity

Receptor activity and turnover of dopamine and noradrenaline after neuroleptics

1970 • 1,041 citations

Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain

1977 • 1,017 citations

PRE AND POSTSYNAPTIC RECEPTORS

1976 • 778 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Psychiatric Aspects of Neurologic Disease

1976 • 674 citations

Effects of chemical stimulation of the mesolimbic dopamine system upon locomotor activity

1976 • 564 citations

Binding characteristics of a radiolabeled agonist and antagonist at central nervous system alpha noradrenergic receptors.

1977 • 544 citations

Behavioural supersensitivity to apomorphine following chronic treatment with drugs which interfere with the synaptic function of catecholamines

1974 • 451 citations

Dopaminergic neurons: An in vivo system for measuring drug interactions with presynaptic receptors

1976 • 350 citations

Morphine catalepsy in the rat: relation to striatal dopamine metabolism

1972 • 338 citations

The role of forebrain dopamine systems in amphetamine induced stereotyped behavior in the rat

1974 • 330 citations

A functional effect of dopamine in the nucleus accumbens and in some other dopamine-rich parts of the rat brain

1975 • 323 citations

Brain neurotransmitter receptors after long-term haloperidol: Dopamine, acetylcholine, serotonin, α-noradrenergic and naloxone receptors

1977 • 304 citations

Tolerance phenomena with neuroleptics catalepsy, apomorphine stereotypies and striatal dopamine metabolism in the rat after single and repeated administration of loxapine and haloperidol

1973 • 256 citations

Persistent Dyskinesia

1973 • 222 citations

Amphetamine-Induced Dopaminergic Hypersensitivity in Guinea Pigs

1975 • 221 citations

Dopamine receptor binding in the corpus striatum of mammalian brain.

1975 • 221 citations

Long-term changes in the sensitivity of pre- and postsynaptic dopamine receptors in mouse striatum evidenced by behavioural and biochemical studies

1977 • 216 citations

Neuroleptic-induced hypersensitivity of striatal dopamine receptors in the rat as a model of tardive dyskinesias. Effects of clozapine, haloperidol, loxapine and chlorpromazine

1975 • 206 citations

Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol

1974 • 195 citations

The mechanisms of action of L-dopa in Parkinson's disease

1974 • 193 citations

The Pathophysiologic Basis of Tardive Dyskinesia

1980 • 190 citations

The behavioural effects of dopamine applied intracerebrally to areas of the mesolimbic system

1975 • 167 citations

Increased sensitivity to dopaminergic agents after chronic neuroleptic treatment.

1975 • 161 citations

Levodopa‐Induced dopamine receptor hypersensitivity

1977 • 147 citations

On the supersensitivity of dopamine receptors, induced by neuroleptics

1976 • 135 citations

Animal Models in Psychiatry

1974 • 135 citations

Increase of 3-methoxy-4-hydroxyphenylethylene glycol in rat brain by neuroleptic drugs

1973 • 124 citations

Haloperidol: Effect of Long-Term Treatment on Rat Striatal Dopamine Synthesis and Turnover

1977 • 123 citations

Neuroleptic and non-neuroleptic catalepsy.

1973 • 118 citations

Tardive dyskinesia: are first signs reversible?

1977 • 116 citations

CHANGES IN MONOAMINE CONCENTRATIONS IN MOUSE BRAIN ASSOCIATED WITH ETHANOL DEPENDENCE AND WITHDRAWAL

1974 • 112 citations

Behavioral evidence for supersensitivity after chronic administration of haloperidol, clozapine, and thioridazine

1976 • 111 citations

EVIDENCE THAT METHADONE BLOCKS DOPAMINE RECEPTORS IN THE BRAIN

1972 • 111 citations

Dopamine-sensitive adenylate cyclase of the caudate nucleus of rats treated with morphine or haloperidol

1975 • 110 citations

Regional differences in homovanillic acid concentrations after acute and chronic administration of antipsychotic drugs

1974 • 110 citations

Tolerance to haloperidol catalepsy

1977 • 106 citations

Dopamine metabolism in the mesolimbic and mesocortical dopaminergic systems after single or repeated administrations of neuroleptics

1976 • 100 citations

Influence of enkephalin on K+-evoked efflux of putative neurotransmitters in rat brain

1977 • 95 citations

Reversal of two manifestations of dopamine receptor supersensitivity by administration of L-dopa.

1977 • 92 citations

Pharmacology of neuroleptics upon repeated administration

1974 • 91 citations

Participation of an endogenous Ca++-blinding protein activator in the development of drug-induced supersensitivity of striatal dopamine receptors.

1977 • 88 citations

Differentiation of opiate and neuroleptic receptor binding in rat brain

1977 • 85 citations

Catalepsy induced by morphine or haloperidol: effects of apomorphine and anticholinergic drugs

1976 • 83 citations

Alterations in dopamine receptor sensitivity by chronic ethanol treatment

1977 • 82 citations

The effect of narcotic analgesics on the homovanillic acid content of rat nucleus caudatus

1973 • 81 citations

The effect of long-term ethanol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens

1976 • 78 citations

Supersensitivity of caudate neurones after repeated administration of haloperidol

1975 • 75 citations

Dopaminergic supersensitivity in striatum and olfactory tubercle following chronic administration of haloperidol of clozapine

1977 • 68 citations

The effect of long-term penfluridol treatment on the sensitivity of the dopamine receptors in the nucleus accumbens and in the corpus striatum

1975 • 65 citations

Effect of morphine on the cerebral contents of metabolites of dopamine in normal and tolerant mice: its possible relation to analgesic action

1972 • 58 citations

Tolerance to the behavioral and neurochemical effects of haloperidol and morphine in rats chronically treated with morphine or haloperidol

1974 • 58 citations

Catalepsy and stereotypies in rats treated with methadone; Relation to striatal dopamine

1974 • 56 citations

The demonstration of a change in adrenergic receptor sensitivity in the central nervous system of mice after withdrawal from long-term treatment with haloperidol

1976 • 52 citations

Effect of chronic amphetamine exposure on stereotyped behavior: implications for pathogenesis of l-dopa-induced dyskinesias.

1975 • 51 citations

Rapid development of hypersensitivity of striatal dopamine receptors induced by alpha-methylparatyrosine and its prevention by protein synthesis inhibitors

1977 • 50 citations

Single and repeated administration of neuroleptic drugs to rats: Effects on striatal dopamine-sensitive adenylate cyclase and locomotor activity produced by tranylcypromine and L-tryptophan or L-dopa

1976 • 48 citations

Alteration in the action of cholinergic and anti cholinergic drugs after chronic haloperidol: Indirect evidence for cholinergic hyposensitivity

1976 • 45 citations

Effect of methadone and dextromoramide on dopamine metabolism: Comparison with haloperidol and amphetamine

1975 • 39 citations

Striatal adenylate cyclase activity following reserpine and chronic chlorpromazine administration in rats

1975 • 39 citations

Assessment of effects of ethanol self-administration on social interactions in alcoholics

1974 • 36 citations

Changes in sensitivity to apomorphine during morphine dependence and withdrawal in rats.

1976 • 35 citations

Differential actions of dopamine agonists and antagonists on the ?-butyrolactone-induced increase in mouse brain dopamine

1976 • 34 citations

The demonstration of a change in responsiveness of mice to physostigmine and atropine after withdrawal from long-term haloperidol pretreatment

1977 • 33 citations

Experimental Ethanol Ingestion: Sleep Variables and Metabolites of Dopamine and Serotonin in the Cerebrospinal Fluid

1975 • 29 citations

Changes in brain cyclic AMP metabolism and acetylcholine and dopamine during narcotic dependence and withdrawal

1975 • 25 citations

Dopamine-sensitive adenylate cyclase of the caudate nucleus of rats treated with morphine

1975 • 25 citations

L-3,4-dihydroxyphenylalanine-induced hypersensitivity simulating features of denervation.

1977 • 21 citations

Dopamine-sensitive adenylate cyclase in homogenates of rat striata during ethanol and barbiturate withdrawal

1976 • 20 citations

Changes in the striatal adenylate cyclase activity following acute and chronic morphine treatment and during withdrawal

1976 • 19 citations

Modification of certain central nervous effects of haloperidol during long-term treatment in the mouse and rat

1969 • 18 citations

Dopamine receptor sensitivity after repeated morphine administrations to rats

1975 • 18 citations

Tolerance to stereotyped behaviour and to decrease in striatal homovanillic acid levels after repeated treatment with apomorphine dipivaloyl ester

1977 • 18 citations

The effects of chronic administration and withdrawal of (+)-amphetamine on seizure threshold and endogenous catecholamine concentrations and their rates of biosynthesis in mice

1977 • 18 citations

Haloperidol-induced tolerance to morphine catalepsy

1977 • 13 citations

Behavioural and biochemical effects of chronic reduction of cerebral noradrenaline receptor stimulation

1977 • 10 citations

[Acute and chronic effects of carpipramine, clozapine, haloperidol and sulpiride on the metabolism of biogenic amines in the rat brain (author's transl)].

1976 • 8 citations