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2000 • 971 citations

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2002 • 673 citations

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1999 • 631 citations

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1995 • 496 citations

The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone

2000 • 494 citations

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

1996 • 475 citations

The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

1998 • 474 citations

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1995 • 454 citations

Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease

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1992 • 439 citations

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1994 • 423 citations

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1993 • 420 citations

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1998 • 396 citations

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1998 • 387 citations

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1999 • 352 citations

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1998 • 329 citations

Hypoxia‐induced activation of HIF‐1: role of HIF‐1α‐Hsp90 interaction

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The 90-kDa heat shock protein, HSP90, binds and protects casein kinase II from self-aggregation and enhances its kinase activity.

1992 • 308 citations

Geldanamycin as a Potential Anti-Cancer Agent: Its Molecular Target and Biochemical Activity

1999 • 297 citations

BCR-ABL point mutants isolated from patients with imatinib mesylate–resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90

2002 • 289 citations

A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

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Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts.

2001 • 250 citations

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1999 • 203 citations

Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide

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Gene expression profiling of human colon cancer cells following inhibition of signal transduction by 17-allylamino-17-demethoxygeldanamycin, an inhibitor of the hsp90 molecular chaperone

2000 • 200 citations

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1997 • 193 citations

Molecular Chaperone Interactions with Steroid Receptors: an Update

2000 • 193 citations

Development of a Purine-Scaffold Novel Class of Hsp90 Binders that Inhibit the Proliferation of Cancer Cells and Induce the Degradation of Her2 Tyrosine Kinase

2002 • 193 citations

Requirement for a Kinase-specific Chaperone Pathway in the Production of a Cdk9/Cyclin T1 Heterodimer Responsible for P-TEFb-mediated Tat Stimulation of HIV-1 Transcription

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Benzoquinonoid ansamycins possess selective tumoricidal activity unrelated to src kinase inhibition.

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The Hsp90 complex—a super-chaperone machine as a novel drug target

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Protein Folding In Vivo: Unraveling Complex Pathways

1997 • 170 citations

A Model for the Cytoplasmic Trafficking of Signalling Proteins Involving the hsp90-Binding Immunophilins and p50cdc37

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Disruption of HSP90 Function Reverts Tumor Necrosis Factor-induced Necrosis to Apoptosis

2003 • 162 citations

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HGF: a multifunctional growth factor controlling cell scattering

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Geldanamycin, a Heat Shock Protein 90-Binding Benzoquinone Ansamycin, Inhibits Steroid-Dependent Translocation of the Glucocorticoid Receptor from the Cytoplasm to the Nucleus

1997 • 146 citations

Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells.

2001 • 145 citations

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In vitro evidence that hsp90 contains two independent chaperone sites

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Binding of ATP to Heat Shock Protein 90

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The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy

2001 • 125 citations

Linking gene expression patterns to therapeutic groups in breast cancer.

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Programmed cell death: many ways for cells to die decently

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Clinical and biological significance of HSP89 alpha in human breast cancer

1992 • 118 citations

Geldanamycin Leads to Superoxide Formation by Enzymatic and Non-enzymatic Redox Cycling

2002 • 118 citations

Reduction of Hypoxia-Induced Transcription through the Repression of Hypoxia-Inducible Factor-1α/Aryl Hydrocarbon Receptor Nuclear Translocator DNA Binding by the 90-kDa Heat-Shock Protein Inhibitor Radicicol

2002 • 116 citations

Halohydrin and Oxime Derivatives of Radicicol: Synthesis and Antitumor Activities

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Auditing the pharmacological accounts for Hsp90 molecular chaperone inhibitors: unfolding the relationship between pharmacokinetics and pharmacodynamics.

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Synthesis and evaluation of geldanamycin-estradiol hybrids

1999 • 106 citations

Potent and specific inhibition of p60v-src protein kinase both in vivo and in vitro by radicicol.

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Novel Concepts in the Development of Platinum Antitumor Drugs

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1996 • 101 citations

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Analysis of native forms and isoform compositions of the mouse 90-kDa heat shock protein, HSP90

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1998 • 100 citations

Hsp90 Inhibition Accelerates Cell Lysis

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2003 • 95 citations

Chronic Hypoxia Increases Endothelial Nitric Oxide Synthase Generation of Nitric Oxide by Increasing Heat Shock Protein 90 Association and Serine Phosphorylation

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Evidence for the Association of the Heme-regulated eIF-2α Kinase with the 90-kDa Heat Shock Protein in Rabbit Reticulocyte Lysate in Situ

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Reactive Cysteines of the 90-kDa Heat Shock Protein, Hsp90

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Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

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Cisplatin Complexes with Phosphatidylserine in Membranes

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Localization and Characterization of the 86- and 84-kDa Heat Shock Proteins in Hepa 1c1c7 Cells

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Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1

2001 • 62 citations

Chick heat-shock protein of Mr = 90,000, free or released from progesterone receptor, is in a dimeric form

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Suppression of RAS and MOS transformation by radicicol.

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Phosphorylation and oligomerization states of native pig brain HSP90 studied by mass spectrometry

2001 • 47 citations

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

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Thrombin Receptor Signaling to Cytoskeleton Requires Hsp90

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Constitutive overexpression of a 89 kDa heat shock protein gene in the HBL100 human mammary cell line converted to a tumorigenic phenotype by the EJ/T24 Harvey-ras oncogene.

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A platform for compartmentalized protein synthesis: protein translation and translocation in the ER

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The Identification of Wos2, a p23 Homologue That Interacts With Wee1 and Cdc2 in the Mitotic Control of Fission Yeasts

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Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells

2001 • 43 citations

The description and antibiotic production of Streptomyces hygroscopicus var. geldanus.

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Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase

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Geldanamycin disrupts platelet-membrane structure, leading to membrane permeabilization and inhibition of platelet aggregation

2000 • 11 citations