Cellular Engineering for the Treatment of Metabolic Disorders: Prospects for Therapy in Diabetes

Direct Gene Transfer into Mouse Muscle in Vivo

1990 • 3,985 citations

Establishment of a Pancreatic β Cell Line That Retains Glucose-Inducible Insulin Secretion: Special Reference to Expression of Glucose Transporter Isoforms*

1990 • 1,212 citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

1992 • 953 citations

Human gene therapy comes of age

1992 • 927 citations

Molecular Biology of Mammalian Glucose Transporters

1990 • 852 citations

Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion

1987 • 773 citations

After Insulin Binds

1987 • 687 citations

Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus

1992 • 620 citations

Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus

1992 • 610 citations

Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

1990 • 579 citations

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

1988 • 523 citations

Pancreatic islet glucose metabolism and regulation of insulin secretion

1986 • 506 citations

Progress Toward Human Gene Therapy

1989 • 484 citations

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

Induction of Donor-Specific Unresponsiveness by Intrathymic Islet Transplantation

1990 • 377 citations

Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation.

1991 • 376 citations

Maintenance of Normoglycemia in Diabetic Mice by Subcutaneous Xenografts of Encapsulated Islets

1991 • 344 citations

Expressing a human proinsulin cDNA in a mouse ACTH-secreting cell. Intracellular storage, proteolytic processing, and secretion on stimulation

1983 • 329 citations

Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector

1990 • 325 citations

31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus.

1992 • 324 citations

Systemic Delivery of Human Growth Hormone by Injection of Genetically Engineered Myoblasts

1991 • 324 citations

A transplantable insulinoma in the rat.

1977 • 308 citations

Targeting Genes: Delivery and Persistent Expression of a Foreign Gene Driven by Mammalian Regulatory Elements in Vivo

1989 • 292 citations

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants.

1991 • 288 citations

Systemic Delivery of Recombinant Proteins by Genetically Modified Myoblasts

1991 • 284 citations

Diabetic Hyperglycemia: Link to Impaired Glucose Transport in Pancreatic β Cells

1991 • 260 citations

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.

1992 • 248 citations

Molecular Physiology of Glucose Transporters

1990 • 224 citations

Biohybrid Artificial Pancreas: Long-Term Implantation Studies in Diabetic, Pancreatectomized Dogs

1991 • 220 citations

Infection of eucaryotic cells by helper-independent recombinant adenoviruses: early region 1 is not obligatory for integration of viral DNA

1984 • 170 citations

Hormone secretagogues increase cytosolic calcium by increasing cAMP in corticotropin-secreting cells.

1985 • 169 citations

Elusive Proximal Signals of β-Cells for Insulin Secretion

1990 • 151 citations

Temporary amelioration of hyperlipidemia in low density lipoprotein receptor-deficient rabbits transplanted with genetically modified hepatocytes.

1990 • 128 citations

Glucokinase Gene Structure: Functional Implications of Molecular Genetic Studies

1990 • 123 citations

The role of phospholipid-derived mediators including arachidonic acid, its metabolites, and inositol triphosphate and of intracellular Ca2+ in glucose-induced insulin secretion by pancretic islets

1987 • 119 citations

The role of ATP and free ADP in metabolic coupling during fuel-stimulated insulin release from islet beta-cells in the isolated perfused rat pancreas.

1991 • 114 citations

Glucose Transport and NIDDM

1992 • 111 citations

Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.

1992 • 110 citations

Modulation of Glucose-Induced Insulin Secretion from a Rat Clonal β-Cell Line*

1990 • 88 citations

Treatment of Severely Diabetic Pancreatectomized Dogs Using a Diffusion-Based Hybrid Pancreas

1992 • 87 citations

Molecular Defects in Diabetes Mellitus

1991 • 85 citations

Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells

1991 • 80 citations

Isolation of Two Complementary Deoxyribonucleic Acid Clones from a Rat Insulinoma Cell Line Based on Similarities to Kex2 and Furin Sequences and the Specific Localization of Each Transcript to Endocrine and Neuroendocrine Tissues in Rats

1991 • 79 citations

Regulation of Insulin-Gene Expression

1987 • 73 citations

The microsomal glucose-6-phosphatase enzyme of pancreatic islets

1988 • 62 citations

Lilly lecture 1990. Molecular defects in diabetes mellitus

1991 • 55 citations

Glucose Cycling in Islets From Healthy and Diabetic Rats

1990 • 51 citations

Polymorphisms of GLUT2 and GLUT4 Genes: Use in Evaluation of Genetic Susceptibility to NIDDM in Blacks

1990 • 50 citations

Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis

1990 • 46 citations

Coexpression of the platelet-derived growth factor (PDGF) B chain and the PDGF beta receptor in isolated pancreatic islet cells stimulates DNA synthesis.

1990 • 41 citations

Tissue-specific expression of transfected human insulin genes in pluripotent clonal rat insulinoma lines induced during passage in vivo.

1988 • 40 citations

Reconstitution of enzymatic activity in hepatocytes of phenylalanine hydroxylase-deficient mice

1992 • 34 citations

An engineered liver glycogen phosphorylase with AMP allosteric activation

1991 • 32 citations

Association between a restriction fragment length polymorphism at the liver/islet cell (GluT 2) glucose transporter and familial Type 2 (non-insulin-dependent) diabetes mellitus

1991 • 30 citations

Transport and metabolism of glucose in an insulin-secreting cell line, .beta.TC-1

1991 • 29 citations

Islet Transplantation in Treating Diabetes

1986 • 27 citations

Clinical application of somatic gene therapy in inborn errors of metabolism

1990 • 26 citations

Heterogeneity of Expression and Secretion of Native and Mutant [Asp^B10]lnsulin in AtT20 Cells

1991 • 16 citations