Evaluation of the Transfer and Expression in Mice of an Enzyme-Encoding Gene Using a Human Adenovirus Vector

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

The Metabolic Basis of Inherited Disease.

1988 • 7,933 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

Chapter 4 Preparation of Isolated Rat Liver Cells

1976 • 5,335 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Functional messenger RNAs are produced by SP6in vitrotranscription of cloned cDNAs

1984 • 1,533 citations

Isolation of adenovirus type 5 host range deletion mutants defective for transformation of rat embryo cells

1979 • 785 citations

Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences

1981 • 657 citations

Prospects for Human Gene Therapy

1984 • 548 citations

Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus.

1976 • 491 citations

Progress Toward Human Gene Therapy

1989 • 484 citations

Transgenic Animals

1988 • 473 citations

Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells.

1984 • 450 citations

Expression of rabies virus glycoprotein from a recombinant vaccinia virus

1984 • 448 citations

Development of adenovirus vectors for the expression of heterologous genes.

1988 • 386 citations

Adeno-associated virus general transduction vectors: analysis of proviral structures

1988 • 347 citations

Host-range mutants of adenovirus type 5 defective for growth in HeLa cells

1977 • 330 citations

Structure and Expression of a Complementary DNA for the Nuclear Coded Precursor of Human Mitochondrial Ornithine Transcarbamylase

1984 • 279 citations

Improved gene expression upon transfer of the adenosine deaminase minigene outside the transcriptional unit of a retroviral vector.

1989 • 192 citations

Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture

1989 • 176 citations

Use of a Liver-Specific Promoter Reduces Immune Response to the Transgene in Adenoviral Vectors

1999 • 173 citations

Correction of the genetic defect in hepatocytes from the Watanabe heritable hyperlipidemic rabbit.

1988 • 155 citations

Retroviruses and embryogenesis: Microinjection of Moloney leukemia virus into midgestation mouse embryos

1980 • 149 citations

Immunogenicity and efficacy testing in chimpanzees of an oral hepatitis B vaccine based on live recombinant adenovirus.

1989 • 144 citations

Retrovirus-mediated transduction of adult hepatocytes.

1988 • 138 citations

Recombinant adenovirus induces antibody response to hepatitis B virus surface antigen in hamsters.

1987 • 130 citations

Genetic Engineering of Novel Genomes of Large DNA Viruses

1985 • 125 citations

Gene expression from transcriptionally disabled retroviral vectors.

1987 • 120 citations

Eight ‘Musts’ for Biotechnology

1988 • 116 citations

The spfash mouse: a missense mutation in the ornithine transcarbamylase gene also causes aberrant mRNA splicing.

1989 • 100 citations

Human purine nucleoside phosphorylase and adenosine deaminase: gene transfer into cultured cells and murine hematopoietic stem cells by using recombinant amphotropic retroviruses.

1987 • 97 citations

Design of retrovirus vectors for transfer and expression of the human beta-globin gene

1988 • 96 citations

Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions.

1987 • 95 citations

Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

1988 • 88 citations

The Simian Virus 40 Small-t Intron, Present in Many Common Expression Vectors, Leads to Aberrant Splicing

1990 • 88 citations

In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses.

1985 • 86 citations

Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes.

1987 • 84 citations

Effects of pH on the kinetics of human liver ornithine-carbamyl phosphate transferase

1968 • 80 citations

Cellular promoters incorporated into the adenovirus genome: cell specificity of albumin and immunoglobulin expression.

1986 • 77 citations

Abundant expression of herpes simplex virus glycoprotein gB using an adenovirus vector

1988 • 74 citations

Transfer of the inducible lac repressor/operator system from Escherichia coli to a vaccinia virus expression vector.

1989 • 72 citations

Ornithine Transcarbamylase Deficiency in Mutant Mice I. Studies on the Characterization of Enzyme Defect and Suitability as Animal Model of Human Disease

1979 • 69 citations

A new allele of the sparse fur gene in the mouse

1974 • 66 citations

High-level transcription from the adenovirus major late promoter requires downstream binding sites for late-phase-specific factors

1990 • 64 citations

Retrovirus Vectors for Gene Transfer: Efficient Integration into and Expression of Exogenous DNA in Vertebrate Cell Genomes

1986 • 63 citations

Import and processing of hybrid proteins by mammalian mitochondria in vitro.

1986 • 62 citations

Genetic Analysis of Adenoviruses

1984 • 58 citations

The simian virus 40 small-t intron, present in many common expression vectors, leads to aberrant splicing.

1990 • 55 citations

Abundant expression of polyomavirus middle T antigen and dihydrofolate reductase in an adenovirus recombinant

1987 • 53 citations

High-level eucaryotic in vivo expression of biologically active measles virus hemagglutinin by using an adenovirus type 5 helper-free vector system

1988 • 51 citations

Overproduction of the protein product of a nonselected foreign gene carried by an adenovirus vector.

1985 • 47 citations

Variable stability of a selectable provirus after retroviral vector gene transfer into human cells.

1986 • 47 citations

Overproduction of polyomavirus middle T antigen in mammalian cells through the use of an adenovirus vector

1987 • 43 citations

Replication-induced stimulation of the major late promoter of adenovirus is correlated to the binding of a factor to sequences in the first intron

1988 • 43 citations

Transfection of hepatic genes into adult rat hepoatocytes in primary culture and their tissue‐specific expression

1989 • 43 citations

Gene expression in implanted rat hepatocytes following retroviral-mediated gene transfer

1989 • 42 citations

Novel RNA family structure of hepatitis B virus expressed in human cells, using a helper-free adenovirus vector

1986 • 42 citations

Position-dependent and -independent mechanisms regulate cell-specific expression of the SpoC1 gene cluster of Aspergillus nidulans.

1987 • 41 citations

Retrovirus Vectors: Promise and Reality

1989 • 39 citations

Stable gene transfer and tissue-specific expression of a human globin gene using adenoviral vectors.

1986 • 38 citations

Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters.

1986 • 30 citations

Correction of mouse ornithine transcarbamytase deficiency by gene transfer into the germ line

1988 • 27 citations

An improved retroviral vector for gene transfer into undifferentiated cells

1989 • 23 citations

Retrovirus vector-mediated gene transfer into hepatocytes.

1989 • 21 citations

Transcription of endogenous C-type viruses in resting and proliferating tissues of BALB/Mo mice

1979 • 21 citations

[48] Methods for analyzing bovine papilloma virus-based calmodulin expression vectors

1987 • 18 citations

Cell-free synthesis and transport of precursors of mutant ornithine carbamoyltransferases into mitochondria

1983 • 16 citations

Source of error in the assay of urinary orotic acid.

1987 • 6 citations

Princeton's Intellectual Trust

1985 • 2 citations