Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

1984 • 698 citations

Post-Translational Proteolysis in Polypeptide Hormone Biosynthesis

1982 • 590 citations

Structure of a yeast pheromone gene (MFα): A putative α-factor precursor contains four tandem copies of mature α-factor

1982 • 587 citations

Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases

1988 • 403 citations

Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase

1983 • 403 citations

Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease.

1989 • 386 citations

[1] High-efficiency cloning of full-length cDNA; Construction and screening of cDNA expression libraries for mammalian cells

1987 • 329 citations

Homologies in serine proteinases

1970 • 239 citations

Yeast KEX2 gene encodes an endopeptidase homologous to subtilisin-like serine proteases

1988 • 236 citations

Secretion and processing of insulin precursors in yeast.

1986 • 227 citations

Sequence of the preprotoxin dsRNA gene of type I killer yeast: Multiple processing events produce a two-component toxin

1984 • 214 citations

Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein.

1986 • 207 citations

Protease B of the lysosomelike vacuole of the yeast Saccharomyces cerevisiae is homologous to the subtilisin family of serine proteases.

1987 • 161 citations

Importance of hydrogen-bond formation in stabilizing the transition state of subtilisin

1986 • 136 citations

Conservation of the sequence of islet amyloid polypeptide in five mammals is consistent with its putative role as an islet hormone.

1989 • 127 citations

Characterization of KEX2-encoded endopeptidase from yeast Saccharomyces, cerevisiae

1989 • 114 citations

Calcium‐dependent KEX2‐like protease found in hepatic secretory vesicles converts proalbumin to albumin

1988 • 72 citations

Gene Transfer Techniques to Study Neuropeptide Processing

1988 • 55 citations

Precursors to regulatory peptides: their proteolytic processing

1987 • 46 citations

Determination of the carboxyl termini of the alpha and beta subunits of yeast K1 killer toxin. Requirement of a carboxypeptidase B-like activity for maturation.

1987 • 44 citations

Putative Convertase Involved in the Proteolytic Conversion of Rat Proalbumin to Serum Albumin1

1988 • 22 citations