Engineering T cells for cancer therapy

Cancer immunotherapy: moving beyond current vaccines

2004 • 2,932 citations

Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes

2002 • 2,781 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

High-Dose Recombinant Interleukin 2 Therapy for Patients With Metastatic Melanoma: Analysis of 270 Patients Treated Between 1985 and 1993

1999 • 1,967 citations

Making Antibodies by Phage Display Technology

1994 • 1,516 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.

1989 • 1,350 citations

Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy.

1995 • 1,320 citations

The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues

1999 • 1,220 citations

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia

1997 • 1,180 citations

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

2002 • 912 citations

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

1997 • 769 citations

Chimeric receptors with 4-1BB signaling capacity provoke potent cytotoxicity against acute lymphoblastic leukemia

2004 • 746 citations

Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product

1998 • 496 citations

Cutting Edge: Persistence of Transferred Lymphocyte Clonotypes Correlates with Cancer Regression in Patients Receiving Cell Transfer Therapy

2004 • 454 citations

Activation of Resting Human Primary T Cells with Chimeric Receptors: Costimulation from CD28, Inducible Costimulator, CD134, and CD137 in Series with Signals from the TCRζ Chain

2004 • 422 citations

α-FETOPROTEIN IN INDIAN CHILDHOOD CIRRHOSIS

1974 • 409 citations

Efficient Transfer of a Tumor Antigen-Reactive TCR to Human Peripheral Blood Lymphocytes Confers Anti-Tumor Reactivity

1999 • 406 citations

Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus–infected subjects

2000 • 385 citations

Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

2001 • 373 citations

Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes

2004 • 368 citations

Adoptive Transfer of Cloned Melanoma-Reactive T Lymphocytes for the Treatment of Patients with Metastatic Melanoma

2001 • 359 citations

A Phase I Study of Nonmyeloablative Chemotherapy and Adoptive Transfer of Autologous Tumor Antigen-Specific T Lymphocytes in Patients With Metastatic Melanoma

2002 • 340 citations

Acute graft-vs-host disease

2001 • 331 citations

IMPACT OF T-CELL DEPLETION ON OUTCOME OF ALLOGENEIC BONE-MARROW TRANSPLANTATION FOR STANDARD-RISK LEUKAEMIAS

1987 • 314 citations

Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes

1998 • 309 citations

Immunity to cancer: attack and escape in T lymphocyte–tumor cell interaction

2002 • 280 citations

Gene Transfer by Retrovirus Vectors Occurs Only in Cells That Are Actively Replicating at the Time of Infection

1990 • 273 citations

Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes.

1995 • 266 citations

T-cell-receptor gene therapy

2002 • 266 citations

High Efficiency TCR Gene Transfer into Primary Human Lymphocytes Affords Avid Recognition of Melanoma Tumor Antigen Glycoprotein 100 and Does Not Alter the Recognition of Autologous Melanoma Antigens

2003 • 231 citations

Long-term in vivo survival of receptor-modified syngeneic T cells in patients with human immunodeficiency virus infection.

2000 • 215 citations

Prolonged survival and tissue trafficking following adoptive transfer of CD4ζ gene-modified autologous CD4+ and CD8+ T cells in human immunodeficiency virus–infected subjects

2000 • 207 citations

Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR

2000 • 171 citations

Survival and Tumor Localization of Adoptively Transferred Melan-A-Specific T Cells in Melanoma Patients

2003 • 163 citations

Functional expression of chimeric receptor genes in human T cells

2001 • 158 citations

A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours

2002 • 158 citations

Carcinoembryonic Antigen as a Target for Therapeutic Anticancer Vaccines: A Review

2002 • 150 citations

Peptide Fine Specificity of Anti-Glycoprotein 100 CTL Is Preserved Following Transfer of Engineered TCRαβ Genes Into Primary Human T Lymphocytes

2003 • 145 citations

Redirecting Mouse CTL Against Colon Carcinoma: Superior Signaling Efficacy of Single-Chain Variable Domain Chimeras Containing TCR-ζ vs FcεRI-γ

2001 • 131 citations

Adoptive transfer of in vitro-targeted, activated T lymphocytes results in total tumor regression.

1997 • 118 citations

Rejection of Syngeneic Colon Carcinoma by CTLs Expressing Single-Chain Antibody Receptors Codelivering CD28 Costimulation

2002 • 105 citations

Human T Lymphocyte Genetic Modification with Naked DNA

2000 • 102 citations

A critical role of T cell antigen receptor-transduced MHC class I-restricted helper T cells in tumor protection

2005 • 98 citations

Bypassing immunization: optimized design of "designer T cells" against carcinoembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA.

1999 • 98 citations

Functional balance between T cell chimeric receptor density and tumor associated antigen density: CTL mediated cytolysis and lymphokine production

2000 • 98 citations

A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA

1999 • 96 citations

Lentiviral-mediated gene transfer into human lymphocytes: role of HIV-1 accessory proteins

2000 • 84 citations

Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer

2002 • 69 citations

Primary Polyclonal Human T Lymphocytes Targeted to Carcino-Embryonic Antigens and Neural Cell Adhesion Molecule Tumor Antigens by CD3ζ-Based Chimeric Immune Receptors

2002 • 68 citations

Engineered CD20-specific primary human cytotoxic T lymphocytes for targeting B-cell malignancy

2003 • 64 citations

Genetic engineering of T cell specificity for immunotherapy of cancer

2002 • 58 citations

Gene Modification Strategies to Induce Tumor Immunity

2005 • 57 citations

Retrovirus-Mediated Gene Transfer into T Cells: 95% Transduction Efficiency without Furtherin VitroSelection

2000 • 56 citations

Human cytotoxic T lymphocytes specific for Wilms’ tumor antigen-1 inhibit engraftment of leukemia-initiating stem cells in non-obese diabetic-severe combined immunodeficient recipients

2003 • 56 citations

T cells engrafted with a recombinant anti-CD30 receptor target autologous CD30+ cutaneous lymphoma cells

2001 • 47 citations

The Recombinant T Cell Receptor Strategy: Insights into Structure and Function of Recombinant Immunoreceptors on the Way Towards an Optimal Receptor Design for Cellular Immunotherapy

2002 • 26 citations

WT1-targeted immunotherapy of leukaemia

2004 • 21 citations

Engineering T-cells with antibody-based chimeric receptors for effective cancer therapy.

2005 • 14 citations

Exploiting alloreactivity for tumour immunotherapy

2004 • 6 citations