The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues

The Immunoglobulin Superfamily—Domains for Cell Surface Recognition

1988 • 2,237 citations

SPECIFIC CARCINOEMBRYONIC ANTIGENS OF THE HUMAN DIGESTIVE SYSTEM

1965 • 1,851 citations

Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule

1989 • 973 citations

THE RADIOIMMUNOASSAY OF CIRCULATING CARCINOEMBRYONIC ANTIGEN OF THE HUMAN DIGESTIVE SYSTEM

1969 • 710 citations

A family of proteins that inhibit signalling through tyrosine kinase receptors

1997 • 648 citations

Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

1991 • 611 citations

Identification of an Antigen from Normal Human Tissue That Crossreacts with the Carcinoembryonic Antigen

1972 • 376 citations

CEA adhesion molecules: multifunctional proteins with signal-regulatory properties

1997 • 284 citations

Cea-related antigens: Molecular biology and clinical significance

1985 • 268 citations

Results of a 400-patient carcinoembryonic antigen second-look colorectal cancer study

1985 • 264 citations

Carcinoembryonic antigen (CEA): Demonstration of a partial identify between CEA and a normal glycoprotein

1972 • 259 citations

The N‐domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae

1996 • 240 citations

Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas.

1993 • 230 citations

Sequence analysis of carcinoembryonic antigen: identification of glycosylation sites and homology with the immunoglobulin supergene family.

1987 • 223 citations

CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues.

1996 • 200 citations

Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen.

1987 • 184 citations

Postsurgical Surveillance of Colon Cancer

1998 • 181 citations

Carcinoembryonic antigens: alternative splicing accounts for the multiple mRNAs that code for novel members of the carcinoembryonic antigen family.

1989 • 173 citations

Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression.

1990 • 162 citations

Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae

1997 • 154 citations

Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen.

1988 • 150 citations

Antigenic sites in carcinoembryonic antigen

1990 • 145 citations

The preparation of purified carcinoembryonic antigen of the human digestive system from large quantities of tumor tissue

1972 • 142 citations

Association of biliary glycoprotein with protein tyrosine phosphatase SHP-1 in malignant colon epithelial cells

1997 • 138 citations

Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern.

1994 • 135 citations

CD66a, CD66b, CD66c, and CD66d each Independently stimulate neutrophils

1996 • 131 citations

Isolation and characterization for carcinoembryonic antigen

1972 • 128 citations

Association of pp60c-src with biliary glycoprotein (CD66a), an adhesion molecule of the carcinoembryonic antigen family downregulated in colorectal carcinomas.

1995 • 128 citations

Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen.

1988 • 127 citations

CD66 family members are associated with tyrosine kinase activity in human neutrophils.

1995 • 121 citations

Immunohistochemistry of Carcino-Embryonic Antigen in the Embryo, Fetus and Adult

1988 • 120 citations

Phase I/II clinical radioimmunotherapy with an iodine-131-labeled anti-carcinoembryonic antigen murine monoclonal antibody IgG.

1997 • 117 citations

Binding of Escherichia coli and Salmonella strains to members of the carcinoembryonic antigen family: differential binding inhibition by aromatic alpha-glycosides of mannose

1991 • 116 citations

Structural studies of the carbohydrate moieties of carcinoembryonic antigens.

1987 • 116 citations

Structure of antigens

1992 • 111 citations

Nature of the tumor-associated determinant(s) of carcinoembryonic antigen.

1975 • 102 citations

Isolation and characterization of carcinoembryonic antigen (CEA) extracted from normal human colon mucosa

1977 • 98 citations

Homotypic and heterotypic Ca++-independent cell adhesion activities of biliary glycoprotein, a member of carcinoembryonic antigen family, expressed on CHO cell surface

1992 • 92 citations

Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors.

1988 • 90 citations

Specificity and affinity of monoclonal antibodies against carcinoembryonic antigen.

1992 • 89 citations

Differential Reactivities of Carcinoembryonic Antigen (CEA) and CEA-Related Monoclonal and Polyclonal Antibodies in Common Epithelial Malignancies

1990 • 89 citations

Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow.

1990 • 85 citations

CD66: role in the regulation of neutrophil effector function

1996 • 84 citations

Isolation and characterization of complementary DNAs encoding human pregnancy-specific beta 1-glycoprotein.

1988 • 82 citations

Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation

1993 • 76 citations

Optimal ratios of biliary glycoprotein isoforms required for inhibition of colonic tumor cell growth.

1997 • 75 citations

Immunohistochemical localization of cellCAM 105 in rat tissues: appearance in epithelia, platelets, and granulocytes.

1988 • 75 citations

Prospective monitoring trial for carcinoma of colon and rectum after surgical resection.

1989 • 73 citations

Escherichia coli of human origin binds to carcinoembryonic antigen (CEA) and non‐specific crossreacting antigen (NCA)

1990 • 73 citations

The Pregnancy-Specific Glycoprotein (PSG) Gene Cluster on Human Chromosome 19: Fine Structure of the 11 PSG Genes and Identification of 6 New Genes Forming a Third Subgroup within the Carcinoembryonic Antigen (CEA) Family

1994 • 71 citations

Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta

1997 • 67 citations

Transcriptional Regulation of the Carcinoembryonic Antigen Gene

1995 • 66 citations

Genomic organization, splice variants and expression of CGM1, a CD66‐related member of the carcinoembryonic antigen gene family

1993 • 66 citations

Extended Glycoprotein Structure of the Seven Domains in Human Carcinoembryonic Antigen by X-ray and Neutron Solution Scattering and an Automated Curve Fitting Procedure: Implications for Cellular Adhesion

1996 • 66 citations

Phase-I/II radio-immunotherapy study with iodine-131-labeled anti-CEA monoclonal antibody F6 F(ab′)2 in patients with non-resectable liver metastases from colorectal cancer

1998 • 62 citations

Decreased expression of biliary glycoprotein in hepatocellular carcinomas

1997 • 62 citations

Identification of the specific oligosaccharide sites recognized by type 1 fimbriae from Escherichia coli on nonspecific cross-reacting antigen, a CD66 cluster granulocyte glycoprotein

1993 • 62 citations

Enhanced tumour specificity of an anti-carcinoembrionic antigen Fab' fragment by poly(ethylene glycol) (PEG) modification

1996 • 62 citations

Purification and properties of biliary glycoprotein I (BGP I). Immunochemical relationship to carcinoembryonic antigen

1979 • 61 citations

Transcription of genes of the carcinoembryonic antigen family in malignant and nonmalignant human tissues.

1988 • 58 citations

Gene Organization of the Pregnancy-Specific Glycoprotein Region on Human Chromosome 19: Assembly and Analysis of a 700-kb Cosmid Contig Spanning the Region

1994 • 57 citations

Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family

1990 • 55 citations

Molecular cloning of nonspecific cross-reacting antigens in human granulocytes

1991 • 54 citations

Cell adhesion and communication mediated by the CEA family : basic and clinical perspectives

1998 • 54 citations

Transcription of carcinoembryonic antigen in normal colon and colon carcinoma. In situ hybridization study and implication for a new in vivo functional model.

1993 • 54 citations

Studies on the structure of the carcinoembryonic antigen—I. Some deductions on the basis of chemical degradations

1974 • 52 citations

Immunochemical identification of a new β1-globulin in the blood serum of pregnant women

1970 • 52 citations

Carbohydrate structures of nonspecific cross-reacting antigen-2, a glycoprotein purified from meconium as an antigen cross-reacting with anticarcinoembryonic antigen antibody

1989 • 51 citations

Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers

1992 • 49 citations

Factors influencing the pharmacokinetics, dosimetry, and diagnostic accuracy of radioimmunodetection and radioimmunotherapy of carcinoembryonic antigen-expressing tumors.

1996 • 49 citations

Four Carcinoembryonic Antigen Subfamily Members, CEA, NCA, BGP and CGM2, Selectively Expressed in the Normal Human Colonic Epithelium, Are Integral Components of the Fuzzy Coat

1999 • 47 citations

Specificity of anti-carcinoembryonic antigen monoclonal antibodies and their effects on CEA-mediated adhesion.

1993 • 46 citations

Glycoproteins of the Carcinoembryonic Antigen (CEA) Family Are Expressed in Sweat and Sebaceous Glands of Human Fetal and Adult Skin

1996 • 43 citations

Expression of carcinoembryonic antigen and nonspecific cross-reacting 50-kDa antigen in human normal and cancerous colon mucosa: comparative ultrastructural study with monoclonal antibodies.

1994 • 42 citations

Nonspecific cross-reacting antigen in normal and leukemic myeloid cells and serum of leukemic patients.

1980 • 42 citations

Definition of the expression of the human carcinoembryonic antigen and non‐specific cross‐reacting antigen in human breast and lung carcinomas

1993 • 41 citations

A polymerase‐chain‐reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)‐gene‐family members

1993 • 41 citations

CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas

1994 • 37 citations

Inhibition of Macrophage Ia Antigen Expression by Shed Plasma Membrane Vesicles From Metastatic Murine Melanoma Lines<xref ref-type="fn" rid="FN1">2</xref>

1985 • 36 citations

Highly Effective Extraction of Carcinoembryonic Antigen with Phosphatidylinositol-Specific Phospholipase C

1991 • 35 citations

Carcinoembryonic antigen-like reactivity in malignant mesothelioma. A comparison between different commercially available antibodies

1994 • 35 citations

Order and genomic distances among members of the carcinoembryonic antigen (CEA) gene family determined by fluorescence in situ hybridization

1992 • 34 citations

Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa.

1995 • 34 citations

Biliary glycoprotein mRNA expression is increased in primary lung cancer, especially in squamous cell carcinoma.

1994 • 33 citations

Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.

1990 • 31 citations

Expression of the CEA gene family members NCA-50/90 and NCA-160 (CD66) in childhood acute lymphoblastic leukemias (ALLs) and in cell lines of B-cell origin.

1994 • 31 citations

Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis.

1997 • 27 citations

Direct comparison of a radioiodinated intact chimeric anti-CEA MAb with its F(ab')2 fragment in nude mice bearing different human colon cancer xenografts

1993 • 26 citations

Transcription of biliary glycoprotein I gene in malignant and non-malignant human liver tissues

1990 • 26 citations

[Immunochemical identification of a new beta-1-globulin in the serum of pregnant women].

1970 • 23 citations

In vitro and in vivo footprint analysis of the promoter of carcinoembryonic antigen in colon carcinoma cells: effects of interferon gamma treatment.

1995 • 23 citations

Site-directed Mutagenesis within an Ectoplasmic ATPase Consensus Sequence Abrogates the Cell Aggregating Properties of the Rat Liver Canalicular Bile Acid Transporter/Ecto-ATPase/Cell CAM 105 and Carcinoembryonic Antigen

1996 • 22 citations

Characterization of cDNA Encoding Novel Pregnancy-Specific Glycoprotein Variants

1995 • 22 citations

Cell adhesion activity of the short cytoplasmic domain isoform of C‐CAM (C‐CAM2) in CHO cells

1995 • 21 citations

A Short Isoform of Carcinoembryonic‐Antigen‐Related Rat Liver Cell‐Cell Adhesion Molecule (C‐CAM/gp110) Mediates Intercellular Adhesion

1995 • 19 citations

Monoclonal antibody COL-1 reacts with restricted epitopes on carcinoembryonic antigen: an immunohistochemical study.

1994 • 16 citations

Serum Level of Biliary Glycoprotein I, a Determinant of Cholestasis, of Similar Use as γ-Glutamyltranspeptidase

1981 • 12 citations