Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1β and TNF-α induced production of inflammatory mediators

Sphingosine-1-phosphate: an enigmatic signalling lipid

2003 • 2,022 citations

Shaping the nuclear action of NF-κB

2004 • 1,183 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

1993 • 955 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 698 citations

Cyclooxygenase-2: A Therapeutic Target

2002 • 656 citations

Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform

2000 • 654 citations

IκB kinases: key regulators of the NF-κB pathway

2004 • 618 citations

Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

2002 • 527 citations

Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation

2003 • 523 citations

Sphingosine Kinase Expression Increases Intracellular Sphingosine-1-Phosphate and Promotes Cell Growth and Survival

1999 • 516 citations

Multiple signals converging on NF-κB

1999 • 483 citations

Sphingosine 1-phosphate signalling in mammalian cells

2000 • 458 citations

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720

2004 • 439 citations

Phosphorylation of the Immunomodulatory Drug FTY720 by Sphingosine Kinases

2003 • 427 citations

Sphingosine Kinase 2 Is a Nuclear Protein and Inhibits DNA Synthesis

2003 • 407 citations

Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway

1998 • 404 citations

Sphingosine Kinase Type 2 Is a Putative BH3-only Protein That Induces Apoptosis

2003 • 352 citations

Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2

2004 • 350 citations

The sphingosine kinase 1/sphingosine‐1‐phosphate pathway mediates COX‐2 induction and PGE₂production in response to TNF‐α

2003 • 318 citations

Transcriptional Regulation of The Human Monocyte Chemoattractant Protein-1 Gene

1997 • 317 citations

Transactivation of Sphingosine-1–Phosphate Receptors by FcεRI Triggering Is Required for Normal Mast Cell Degranulation and Chemotaxis

2004 • 313 citations

Ceramide Kinase, a Novel Lipid Kinase

2002 • 292 citations

Sphingosine Kinase Interacts with TRAF2 and Dissects Tumor Necrosis Factor-α Signaling

2002 • 291 citations

Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases

2002 • 275 citations

Activation of Sphingosine Kinase by Tumor Necrosis Factor-α Inhibits Apoptosis in Human Endothelial Cells

1999 • 270 citations

Point-Counterpoint of Sphingosine 1-Phosphate Metabolism

2004 • 251 citations

Nuclear factor-kappa B potently up-regulates the promoter activity of RANTES, a chemokine that blocks HIV infection.

1997 • 238 citations

N,N-Dimethylsphingosine Is a Potent Competitive Inhibitor of Sphingosine Kinase but Not of Protein Kinase C: Modulation of Cellular Levels of Sphingosine 1-Phosphate and Ceramide

1998 • 229 citations

Ceramide Kinase Mediates Cytokine- and Calcium Ionophore-induced Arachidonic Acid Release

2003 • 213 citations

IκBα Degradation and Nuclear Factor-κB DNA Binding Are Insufficient for Interleukin-1β and Tumor Necrosis Factor-α-induced κB-dependent Transcription

1998 • 194 citations

Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation

2000 • 186 citations

Sphingosine-1-phosphate receptors: receptor specificity versus functional redundancy

2004 • 178 citations

Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines

1996 • 168 citations

Dichotomy of Ca2+ Signals Triggered by Different Phospholipid Pathways in Antigen Stimulation of Human Mast Cells

2002 • 164 citations

Sphingosine kinases: A novel family of lipid kinases

2002 • 158 citations

Sphingosine Kinase Transmits Estrogen Signaling in Human Breast Cancer Cells

2003 • 149 citations

Down-regulation of Sphingosine Kinase-1 by DNA Damage

2004 • 129 citations

Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.

1991 • 123 citations

Sphingolipids in Inflammation: Roles and Implications

2004 • 122 citations

Upregulation of Bcl-x and Bfl-1 as a potential mechanism of chemoresistance, which can be overcome by NF-κB inhibition

2000 • 109 citations

IL‐1β‐dependent activation of NF‐κB mediates PGE₂ release via the expression of cyclooxygenase‐2 and microsomal prostaglandin E synthase

2003 • 99 citations

Antisense Knockdown of Sphingosine Kinase 1 in Human Macrophages Inhibits C5a Receptor-Dependent Signal Transduction, Ca2+ Signals, Enzyme Release, Cytokine Production, and Chemotaxis

2004 • 92 citations

The role of sphingosine and ceramide kinases in inflammatory responses

2004 • 88 citations

TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells.

1999 • 77 citations

Sphingosine Kinase Protects Lipopolysaccharide-Activated Macrophages from Apoptosis

2004 • 76 citations

Sphingosine kinase-1 mediates TNF-α-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow

2004 • 76 citations

Anaphylatoxin Signaling in Human Neutrophils

2004 • 72 citations

Sphingosine-1-phosphate Mobilizes Intracellular Calcium and Activates Transcription Factor NF-κB in U937 Cells

1997 • 71 citations

TNF Receptor-Associated Factor-2 Is Involved in Both IL-1β and TNF-α Signaling Cascades Leading to NF-κB Activation and IL-8 Expression in Human Intestinal Epithelial Cells

1999 • 67 citations

Positive Modulation of IL-12 Signaling by Sphingosine Kinase 2 Associating with the IL-12 Receptor β1 Cytoplasmic Region

2003 • 64 citations

Involvement of protein kinase C-gamma in IL-1beta-induced cyclooxygenase-2 expression in human pulmonary epithelial cells.

2000 • 62 citations

In vitro and in vivo induction of apoptosis by sphingosine and N, N-dimethylsphingosine in human epidermoid carcinoma KB-3-1 and its multidrug-resistant cells.

1997 • 62 citations

Protein kinase C and platelet inhibition by D-erythro-sphingosine: Comparison with N,N-dimethylsphingosine and commercial preparation

1990 • 56 citations

Combined histone deacetylase and NF-κB inhibition sensitizes non-small cell lung cancer to cell death

2004 • 56 citations

Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine

2002 • 32 citations

Voies de signalisation de l’apoptose médiées par les sphingolipides

2003 • 6 citations