IκBα Degradation and Nuclear Factor-κB DNA Binding Are Insufficient for Interleukin-1β and Tumor Necrosis Factor-α-induced κB-dependent Transcription

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor.

1994 • 1,057 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

NF-κB Activation: The IκB Kinase Revealed?

1997 • 492 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.

1994 • 423 citations

Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β

1997 • 390 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.

1993 • 331 citations

Redox status of cells influences constitutive or induced NF-kappa B translocation and HIV long terminal repeat activity in human T and monocytic cell lines.

1992 • 242 citations

Cell death induction by receptors of the TNF family: towards a molecular understanding

1997 • 237 citations

zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro.

1994 • 231 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Three NF-χB sites in the IχB-α promoter are required for induction of gene expression by TNFα

1994 • 219 citations

Role of I Bα Ubiquitination in Signal-induced Activation of NF- B in Vivo

1996 • 216 citations

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase‐1β (Rsk‐2) and p70 S6 kinase

1997 • 206 citations

Analysis of the Role of Protein Kinase C-α, -ε, and -ζ in T Cell Activation

1995 • 184 citations

Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells

1996 • 153 citations

Identification of a new serine kinase that activates NF kappa B by direct phosphorylation.

1993 • 96 citations

Human Inducible Nitric Oxide Synthase Gene Is Transcriptionally Regulated by Nuclear Factor-κB Dependent Mechanism

1996 • 92 citations

Superinduction of NF-κB by Actinomycin D and Cycloheximide in Epithelial Cells

1996 • 83 citations

Involvement of Phosphatidylcholine-specific Phospholipase C in Platelet-derived Growth Factor-induced Activation of the Mitogen-activated Protein Kinase Pathway in Rat-1 Fibroblasts

1997 • 71 citations

Characterization of IκB Kinases

1996 • 69 citations

Protein-tyrosine Kinase Activation Is Required for Lipopolysaccharide Induction of Interleukin 1β and NFκB Activation, but Not NFκB Nuclear Translocation

1996 • 66 citations

Tumor Necrosis Factor α Activates NF-κB in Acid Sphingomyelinase-deficient Mouse Embryonic Fibroblasts

1997 • 64 citations

The Role of Src Kinase in the Potentiation by Ethanol of Cytokine- and Endotoxin-Mediated Nitric Oxide Synthase Expression in Rat Hepatocytes

1997 • 19 citations

Dissociation of tyrosine phosphorylation and activation of phosphoinositide phospholipase C induced by the protein kinase C inhibitor Ro-31-8220 in Swiss 3T3 cells treated with platelet-derived growth factor

1997 • 18 citations

The protein tyrosine kinase Fyn activates transcription from the HIV promoter via activation of NFkB-like DNA-binding proteins

1995 • 17 citations