New Anti-inflammatory Treatment Strategy in Alzheimer’s Disease

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease

1996 • 1,371 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Clinical trial of indomethacin in Alzheimer's disease

1993 • 996 citations

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1997 • 990 citations

Cyclo-Oxygenase-2 Gene Expression in Neurons Contributes to Ischemic Brain Damage

1997 • 728 citations

Glial‐Neuronal Interactions in Alzheimer's Disease: The Potential Role of a ‘Cytokine Cycle’ in Disease Progression

1998 • 695 citations

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

1997 • 601 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

Inverse association of anti‐inflammatory treatments and Alzheimer's disease

1994 • 567 citations

Elevated circulating tumor necrosis factor levels in Alzheimer's disease

1991 • 489 citations

The enzymatic formation of prostaglandin E2 from arachidonic acid prostaglandins and related factors 32

1964 • 473 citations

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs

1995 • 460 citations

Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain

1998 • 455 citations

Brain macrophages: evaluation of microglia and their functions

1992 • 443 citations

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

1995 • 442 citations

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

1997 • 416 citations

Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease.

1992 • 362 citations

Amyloid β-peptide stimulates nitric oxide production in astrocytes through an NFκB-dependent mechanism

1998 • 339 citations

Activation of the NF-κB Pathway by Inflammatory Stimuli in Human Neutrophils

1997 • 321 citations

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

1998 • 313 citations

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?

1995 • 284 citations

Mechanism of action of antiinflammatory drugs.

1998 • 266 citations

Involvement of NF‐κB in the regulation of cyclooxygenase‐2 protein expression in LPS‐stimulated J774 macrophages

1997 • 266 citations

The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes

1995 • 266 citations

THE ROLE OF ANTI-INFLAMMATORY DRUGS IN THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE

1996 • 256 citations

Molecular and Cellular Characterization of the Membrane Attack Complex, C5b-9, in Alzheimer’s Disease

1997 • 254 citations

Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging

1998 • 246 citations

Oxygenation of biological membranes by the pure reticulocyte lipoxygenase.

1990 • 244 citations

Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease

1999 • 243 citations

Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs

1999 • 237 citations

Increased Cerebral Glucose‐6‐Phosphate Dehydrogenase Activity in Alzheimer's Disease May Reflect Oxidative Stress

1986 • 226 citations

Leukotriene B4

1998 • 208 citations

Increased Expression of Cyclooxygenases and Peroxisome Proliferator-Activated Receptor-γ in Alzheimer's Disease Brains

1999 • 205 citations

Complement Biosynthesis in the Central Nervous System

1995 • 199 citations

Cyclo-Oxygenase Isoenzymes

1997 • 198 citations

Evidence of an oxidative challenge in the Alzheimer's brain

1994 • 194 citations

The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation

1998 • 187 citations

Strong nuclear factor-?B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex

1998 • 181 citations

Interleukin-1-induced cyclooxygenase 2 expression is suppressed by cyclosporin A in rat mesangial cells

1994 • 176 citations

Brain interleukin-1 beta in Alzheimer's disease and vascular dementia.

1994 • 176 citations

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

1990 • 174 citations

Decreased Catalase Activity but Unchanged Superoxide Dismutase Activity in Brains of Patients with Dementia of Alzheimer Type

1995 • 168 citations

Inhibition of the Expression of Inducible Cyclooxygenase and Proinflammatory Cytokines by Sesquiterpene Lactones in Macrophages Correlates with the Inhibition of MAP Kinases

1996 • 158 citations

Interleukin-1β and Glutamate Activate the NF-κB/Rel Binding Site from the Regulatory Region of the Amyloid Precursor Protein Gene in Primary Neuronal Cultures

1996 • 152 citations

Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus.

1995 • 150 citations

NSAIDs and incident Alzheimer’s disease. the Rotterdam study

1998 • 149 citations

Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation

1998 • 145 citations

Aspartate residue 7 in amyloid β-protein is critical for classical complement pathway activation: Implications for Alzheimer's disease pathogenesis

1997 • 143 citations

Blood levels of histamine, IL-1β, and TNF-α in patients with mild to moderate alzheimer disease

1996 • 138 citations

Nitric oxide synthase gene expression in cholinergic neurons in the rat brain examined by combined immunocytochemistry and in situ hybridization histochemistry

1994 • 122 citations

Interaction of 5-lipoxygenase with cellular proteins

1999 • 120 citations

Aging‐associated up‐regulation of neuronal 5‐lipoxygenase expression: putative role in neuronal vulnerability

1998 • 118 citations

The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease

1996 • 114 citations

Arachidonate 5‐Lipoxygenase and Its Activating Protein: Prominent Hippocampal Expression and Role in Somatostatin Signaling

1996 • 113 citations

Nonsteroidal Anti-Inflammatory Drug Use and Alzheimer's Disease: A Case-Control Study in Rochester, Minnesota, 1980 Through 1984

1998 • 113 citations

Molecular Indices of Neuronal and Glial Plasticity in the Hippocampal Formation in a Rodent Model of Age-Induced Spatial Learning Impairment

1996 • 105 citations

α2-macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease

1993 • 101 citations

MAP Kinase Pathways as a Route for Regulatory Mechanisms of IL-10 and IL-4 Which Inhibit COX-2 Expression in Human Monocytes

1998 • 101 citations

Prostaglandin E₂ Induces Interleukin‐6 Synthesis in Human Astrocytoma Cells

1997 • 98 citations

Indomethacin Reverses the Microglial Response to Amyloid β-Protein

1998 • 94 citations

Selective COX-2 inhibitors: is the water becoming muddy?

1999 • 83 citations

Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family.

1992 • 78 citations

Reperfusion induces 5-lipoxygenase translocation and leukotriene C4 production in ischemic brain

1995 • 77 citations

Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive decline

1998 • 74 citations

Neuroglial-mediated immunoinflammatory responses in Alzheimer's disease: Complement activation and therapeutic approaches

1996 • 70 citations

Release of Leukotriene B₄ from Sublethally Injured Oligodendrocytes by Terminal Complement Complexes

1987 • 69 citations

Serum α1-antichymotrypsin level as a marker for Alzheimer-type dementia

1995 • 66 citations

Distribution of Aβ-associated proteins in cerebrovascular amyloid of Alzheimer's disease

1998 • 64 citations

Glucocorticoids Stimulate Inflammatory 5‐Lipoxygenase Gene Expression and Protein Translocation in the Brain

1999 • 64 citations

Cytotoxic effect of HIV-1 coat glycoprotein gp120 on human neuroblastoma CHP100 cells involves activation of the arachidonate cascade

1998 • 59 citations

Protective effect of the 5-lipoxygenase inhibitor AA-861 on cerebral edema after transient ischemia

1996 • 58 citations

Indicators of glial activation and brain oxidative stress after intraventricular infusion of endotoxin

1998 • 58 citations

Effects of tepoxalin, a dual inhibitor of cyclooxygenase/5-lipoxygenase, on events associated with NSAID-induced gastrointestinal inflammation

1997 • 58 citations

Cultured Rat Microglia Express C1q and Receptor for C1q: Implications for Amyloid Effects on Microglia

1995 • 57 citations

Interleukin‐1β and Tumor Necrosis Factor‐α Induce Expression of α₁‐Antichymotrypsin in Human Astrocytoma Cells by Activation of Nuclear Factor‐κB

1996 • 56 citations

Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus

1997 • 54 citations

A Pilot Study of Prednisone in Alzheimer's Disease

1996 • 48 citations

Increased Hippocampal 5‐Lipoxygenase mRNA Content in Melatonin‐Deficient, Pinealectomized Rats

1997 • 47 citations

IL-1 and anti-inflammatory drugs modulate A β cytotoxicity in PC12 cells

1996 • 44 citations

Circadian expression of pineal 5-lipoxygenase mRNA

1998 • 42 citations

Primary rat astroglial cultures can generate leukotriene B4

1988 • 41 citations

Enhanced Processing of APP Induced by IL-1β Can Be Reduced by Indomethacin and Nordihydroguaiaretic Acid

1995 • 39 citations

Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and β-amyloid

1998 • 33 citations

Inflammatory molecule release by β-amyloid-treated T98G astrocytoma cells: role of prostaglandins and modulation by paracetamol

1998 • 33 citations

Improving the gastrointestinal safety of NSAIDs: the development of misoprostol--from hypothesis to clinical practice.

1998 • 30 citations

Complement activation by cross-linked truncated and chimeric full-length β-amyloid

1997 • 28 citations

Blocking the interleukin-1 receptor inhibits leukotriene B4 and prostaglandin E2 generation in human monocyte cultures

1992 • 28 citations

Priming for the synthesis of 5-lipoxygenase products in human blood ex vivo by human granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha.

1994 • 27 citations

Primary Cultures of Rat Cerebellar Granule Cells as a Model to Study Neuronal 5‐Lipoxygenase and FLAP Gene Expression

1999 • 26 citations

5-Lipoxygenase gene polymorphism and onset of Alzheimer's disease

2000 • 24 citations

Potential link between interleukin-6 and arachidonic acid metabolism in Alzheimer’s disease

1998 • 24 citations

Down‐regulation of cyclooxygenase‐2 (COX‐2) by interleukin‐1 receptor antagonist in human monocytes

1996 • 23 citations

Arachidonate Metabolites Affect the Secretion of an N-Terminal Fragment of Alzheimer′s Disease Amyloid Precursor Protein

1995 • 22 citations

Induction of manganese superoxide dismutase in BV-2 microglial cells

1997 • 22 citations

Immunostimulation protects microglial cells from nitric oxide-mediated apoptosis

1997 • 21 citations

Nonsteroidal Anti-Inflammatory Drugs as Scaffolds for the Design of 5-Lipoxygenase Inhibitors

1997 • 21 citations

Protection from hypoxic and N-methyl-D-aspartate injury with azelastine, a leukotriene inhibitor

1993 • 21 citations

Age‐dependent change in arachidonic acid metabolic capacity in rat alveolar macrophages

1999 • 18 citations

Microglia and immune activation in Alzheimer's disease.

1993 • 18 citations

Thrombin Stimulates Activation of the Cerebral 5-Lipoxygenase Pathway during Blood-Brain Cell Contact

1996 • 15 citations

Simplified quantitation of gene transcripts in cultured neuroblastoma (SN49) and microglial (BV-2) cells using capillary electrophoresis and laser-induced fluorescence

1996 • 15 citations

THE MIXED LIPOXYGENASE/CYCLOOXYGENASE INHIBITOR SK&F 105809 REDUCES CEREBRAL EDEMA AFTER CLOSED HEAD INJURY IN RAT

1992 • 13 citations

Azelastine protects against CA1 traumatic neuronal injury in the hippocampal slice

1996 • 11 citations

Prostaglandin E2 Induced Polymerization of Human α-1-Antichymotrypsin and Suppressed Its Protease Inhibitory Activity: Implications for Alzheimer's Disease

1998 • 7 citations

Pharmacological Aspects of 5-Lipoxygenase Inhibition

1999 • 2 citations