Down‐regulation of cyclooxygenase‐2 (COX‐2) by interleukin‐1 receptor antagonist in human monocytes

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

The Role of Interleukin-1 in Disease

1993 • 967 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

The eicosanoids and their biochemical mechanisms of action

1989 • 882 citations

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

1992 • 838 citations

Blocking IL-1: interleukin 1 receptor antagonist in vivo and in vitro

1991 • 729 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Biological properties of recombinant human monocyte-derived interleukin 1 receptor antagonist.

1990 • 569 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Endogenous glucocorticoids regulate an inducible cyclooxygenase enzyme.

1992 • 471 citations

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

1990 • 404 citations

Regulation of fibroblast cyclooxygenase synthesis by interleukin-1.

1988 • 401 citations

Prostacyclin Synthesis Induced in Vascular Cells by Interleukin-1

1985 • 364 citations

In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis.

1992 • 353 citations

Effects of immune complexes on production by human monocytes of interleukin 1 or an interleukin 1 inhibitor.

1985 • 325 citations

Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes.

1994 • 310 citations

Interleukin 1 activates phospholipase A2 in rabbit chondrocytes: a possible signal for IL 1 action.

1986 • 259 citations

IL-1 receptor antagonist and IL-1 beta production in human monocytes are regulated differently.

1991 • 219 citations

Human platelet-derived growth factor stimulates prostaglandin synthesis by activation and by rapid de novo synthesis of cyclooxygenase.

1985 • 219 citations

Lipopolysaccharide priming of alveolar macrophages for enhanced synthesis of prostanoids involves induction of a novel prostaglandin H synthase.

1992 • 212 citations

Prostaglandin E2 and collagenase production by fibroblasts and synovial cells is regulated by urine-derived human interleukin 1 and inhibitor(s).

1986 • 211 citations

Lipopolysaccharide induces prostaglandin H synthase-2 in alveolar macrophages

1992 • 129 citations

Recombinant tumor necrosis factor and intepleukin-1 both stimulate human synovial cell arachidonic acid release and phospholipid metabolism

1987 • 110 citations

Modalities for reducing interleukin 1 activity in disease

1993 • 91 citations

Interleukin‐1β and transforming growth factor‐β₂ enhance cytosolic high‐molecular‐mass phospholipase A₂ activity and induce prostaglandin E₂ formation in rat mesangial cells

1992 • 80 citations

Interleukin-1 stimulates prostacyclin production by cultured human endothelial cells by increasing arachidonic acid mobilization and conversion.

1990 • 41 citations

Blocking the interleukin-1 receptor inhibits leukotriene B4 and prostaglandin E2 generation in human monocyte cultures

1992 • 28 citations

Loss of thyrotropin regulation and transforming growth factor beta-induced growth arrest in erbB-2 overexpressing rat thyroid cells.

1993 • 19 citations