Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive decline

GAP-43: an intrinsic determinant of neuronal development and plasticity

1997 • 1,285 citations

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

1992 • 899 citations

Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.

2015 • 856 citations

Oxidative processes and antioxidative defense mechanisms in the aging brain ¹

1995 • 810 citations

Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.

1993 • 653 citations

Preserved neuron number in the hippocampus of aged rats with spatial learning deficits.

1996 • 635 citations

Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases

1989 • 470 citations

THE USE OF ANIMAL MODELS TO STUDY THE EFFECTS OF AGING ON COGNITION

1997 • 414 citations

Nerve growth factor and Alzheimer's disease

1986 • 378 citations

Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.

2013 • 334 citations

Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging

1992 • 294 citations

Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals

1995 • 292 citations

Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus

1991 • 280 citations

Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.

1995 • 243 citations

NGF induction of NGF receptor gene expression and cholinergic neuronal hypertrophy within the basal forebrain of the adult rat

1989 • 243 citations

Decreased level of nerve growth factor (NGF) and its messenger RNA in the aged rat brain

1987 • 237 citations

Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system—I. Forebrain

1990 • 224 citations

Age and neurochemical correlates of radial maze performance in rats

1981 • 217 citations

Relationship of age-related decline across several behavioral domains

1989 • 195 citations

Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid β-Protein Production in Human Neuronal NT2N Cells

1995 • 188 citations

Brain Aging: Changes in the Nature of Information Coding by the Hippocampus

1997 • 162 citations

The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease.

1991 • 159 citations

Cholinesterase inhibitors increase secretion of APPs in rat brain cortex

1995 • 157 citations

Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system—II. Brainstem, cerebellum and spinal cord

1990 • 148 citations

Markers for biogenic amines in the aged rat brain: Relationship to decline in spatial learning ability

1990 • 146 citations

Nerve growth factor levels and choline acetyltransferase activity in the brain of aged rats with spatial memory impairments

1990 • 136 citations

Septal cholinergic afferents regulate expression of brain-derived neurotrophic factor andβ-nerve growth factor mRNA in rat hippocampus

1992 • 122 citations

Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated trka expression in the medial septum of aged rats

1994 • 121 citations

Intact spatial learning following lesions of basal forebrain cholinergic neurons

1996 • 121 citations

Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS

1994 • 120 citations

Spatial memory deficits in aged rats: contributions of the cholinergic system assessed by ChAT

1990 • 120 citations

Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input.

1996 • 115 citations

Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation.

1993 • 115 citations

Promoter activity of the gene encoding the beta-amyloid precursor protein is up-regulated by growth factors, phorbol ester, retinoic acid and interleukin-1

1995 • 106 citations

Nerve growth factor receptors in the central nervous system

1988 • 106 citations

Molecular Indices of Neuronal and Glial Plasticity in the Hippocampal Formation in a Rodent Model of Age-Induced Spatial Learning Impairment

1996 • 105 citations

Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert

1991 • 105 citations

Intact spatial learning in both young and aged rats following selective removal of hippocampal cholinergic input.

1996 • 97 citations

Age-related decrease in cholinergic synaptic transmission in three hippocampal subfields

1996 • 97 citations

Spatial learning deficits in the aged rat: neuroanatomical and neurochemical correlates

1994 • 92 citations

Hippocampal nerve growth factor levels are related to spatial learning ability in aged rats

1992 • 91 citations

Cholinergic regulation of hippocampal brain-derived neurotrophic factor mRNA expression: Evidence from lesion and chronic cholinergic drug treatment studies

1993 • 83 citations

Pharmacological Induction of Nerve Growth Factor mRNA in Adult Rat Brain

1993 • 74 citations

VGF expression in the brain

1994 • 71 citations

Differential Regulation of Hippocampal Neurotrophins During Aging in Rats

1996 • 68 citations

Altered levels of amyloid protein precursor transcripts in the basal forebrain of behaviorally impaired aged rats.

1990 • 66 citations

Hippocampal NGF levels are not reduced in the aged Fischer 344 rat

1991 • 65 citations

Nerve Growth Factor and Ras Regulate β‐Amyloid Precursor Protein Gene Expression in PC12 Cells

1996 • 53 citations

Nerve growth factor-induced neuronal differentiation is accompanied by differential induction and localization of the amyloid precursor protein (APP) in PC12 cells and variant PC12S cells

1993 • 52 citations

The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from chinese hamster ovary-m1 cells

1995 • 52 citations

Transcriptional regulation of neuromodulin (GAP-43) in mouse neuroblastoma clone N1E-115 as evaluated by the RT/PCR method

1992 • 51 citations

Increased NGF-like activity in young but not aged rat hippocampus after septal lesions

1994 • 49 citations

Hippocampal muscarinic receptor function in spatial learning-impaired aged rats

1995 • 49 citations

Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats, and its exacerbation in aged rats

1995 • 49 citations

Messenger RNAs of β‐amyloid precursor protein and prion protein are regulated by nerve growth factor in PC12 cells

1988 • 49 citations

Differential expression of p140trk, p75NGFR and growth-associated phosphoprotein-43 genes in nucleus basalis magnocellularis, thalamus and adjacent cortex following neocortical infarction and nerve growth factor treatment

1995 • 46 citations

The Effect of Cholinesterase Inhibitors on the Secretion of APPS from Rat Brain Cortexa

1996 • 42 citations

Role of the cholinergic system in the regulation of neurotrophin synthesis

1995 • 40 citations

Nerve growth factor-induced neuronal differentiation is accompanied by differential splicing of β-amyloid precursor mRNAs in the PC12 cell line

1991 • 39 citations

Relationship of APP mRNA transcripts and levels of NGF and low-affinity NGF receptors to behavioral measures of age-related cognitive dysfunction

1994 • 37 citations

Regulation of proteolytic processing of the amyloid β-protein precursor of Alzheimer’s disease in transfected cell lines and in brain slices

1994 • 31 citations

Expression and polarization of VGF in developing hippocampal neurons

1996 • 28 citations

Chapter 29: The neurotrophic hypothesis and the cholinergic basal forebrain projection

1993 • 27 citations

Activation of basal forebrain cholinergic neurons differentially regulates brain-derived neurotrophic factor mRNA expression in different projection areas

1992 • 27 citations

Chronic treatment with scopolamine and physostigmine changes nerve growth factor (NGF) receptor density and NGF content in rat brain

1991 • 27 citations

vgf A neurotrophin-inducible gene expressed in neuroendocrine tissues

1996 • 22 citations

Simplified quantitation of gene transcripts in cultured neuroblastoma (SN49) and microglial (BV-2) cells using capillary electrophoresis and laser-induced fluorescence

1996 • 15 citations

Differential expression of GAP-43 mRNA in adult central cholinergic neuronal populations

1994 • 15 citations

Stimulation of vgf gene expression by NGF is mediated through multiple signal transduction pathways involving protein phosphorylation

1995 • 14 citations

Increased β-amyloid precursor protein mRNA in the rat cerebral cortex and hippocampus after chronic systemic atropine treatment

1996 • 13 citations

Do central nervous system neurons require target-derived neurotrophic support for survival throughout adult life and aging?

1996 • 12 citations

Nerve Growth Factor Content of Rat Brain Increases Following Basal-Forebrain Lesions Induced by Ibotenic Acid but Not by Electrolysis.

1994 • 5 citations