Activation of transcription factor NF-kappaB by the Tat protein of human immunodeficiency virus type 1

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Cellular uptake of the tat protein from human immunodeficiency virus

1988 • 2,690 citations

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 • 2,203 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Structure, Regulation and Function of NF-kappaB

1994 • 2,110 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway

1993 • 1,141 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120

1995 • 983 citations

In Vivo Footprinting of a Muscle Specific Enhancer by Ligation Mediated PCR

1989 • 972 citations

Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

1990 • 899 citations

Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation

1993 • 805 citations

Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kappa B sites in the long terminal repeat.

1989 • 781 citations

HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA

1986 • 673 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

CONTROL OF RNA INITIATION AND ELONGATION AT THE HIV-1 PROMOTER

1994 • 613 citations

Activation of HIV gene expression during monocyte differentiation by induction of NF-kB

1989 • 590 citations

Induction of Apoptosis in Uninfected Lymphocytes by HIV-1 Tat Protein

1995 • 581 citations

Endocytosis and targeting of exogenous HIV-1 Tat protein.

1991 • 481 citations

HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state.

1995 • 386 citations

Cloning of an Intrinsic Human TFIID Subunit That Interacts with Multiple Transcriptional Activators

1995 • 385 citations

Regulation of Gene Expression with Double-Stranded Phosphorothioate Oligonucleotides

1990 • 373 citations

Inhibition of Antigen-Induced Lymphocyte Proliferation by Tat Protein from HIV-1

1989 • 338 citations

Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor

1995 • 338 citations

Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1

1991 • 305 citations

Mechanism of action of regulatory proteins encoded by complex retroviruses

1992 • 299 citations

Human immunodeficiency virus long terminal repeat responds to T-cell activation signals.

1987 • 292 citations

Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines

1992 • 289 citations

A novel procedure for quantitative polymerase chain reaction by coamplification of competitive templates

1992 • 272 citations

Alternative Mechanisms for Activation of Human Immunodeficiency Virus Enhancer in T Cells

1988 • 265 citations

Activation of human immunodeficiency virus type 1 by DNA damage in human cells

1988 • 256 citations

Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat

1992 • 254 citations

TAR-independent activation of the HIV-1 LTR: Evidence that Tat requires specific regions of the promoter

1990 • 253 citations

Direct interaction of human TFIID with the HIV-1 transactivator Tat

1994 • 251 citations

The expression of the interleukin 6 gene is induced by the human immunodeficiency virus 1 TAT protein.

1994 • 250 citations

Absolute dependence on kappa B responsive elements for initiation and Tat-mediated amplification of HIV transcription in blood CD4 T lymphocytes.

1995 • 233 citations

Repression of MHC Class I Gene Promoter Activity by Two-Exon Tat of HIV

1993 • 223 citations

In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor

1993 • 218 citations

tat protein stimulates production of transforming growth factor-beta 1 by marrow macrophages: a potential mechanism for human immunodeficiency virus-1-induced hematopoietic suppression

1992 • 199 citations

Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells

1994 • 184 citations

Expression of influenza virus hemagglutinin activates transcription factor NF-kappa B

1995 • 181 citations

A Quantitative Bioassay for HIV-1 Based on Trans-Activation

1988 • 180 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

Human immunodeficiency virus type 1 Tat protein protects lymphoid, epithelial, and neuronal cell lines from death by apoptosis.

1993 • 128 citations

Novel mechanism and factor for regulation by HIV-1 Tat.

1995 • 128 citations

Sp1-dependent activation of a synthetic promoter by human immunodeficiency virus type 1 Tat protein.

1991 • 124 citations

Mechanism of HIV-1 Tat induced inhibition of antigen-specific T cell responsiveness.

1993 • 123 citations

TAR independent activation of the human immunodeficiency virus in phorbol ester stimulated T lymphocytes.

1990 • 121 citations

The human immunodeficiency virus type 1 Tat protein transactivates tumor necrosis factor beta gene expression through a TAR-like structure

1994 • 119 citations

Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS

1992 • 119 citations

HIV-1 tat gene induces tumor necrosis factor-beta (lymphotoxin) in a human B-lymphoblastoid cell line

1990 • 111 citations

Cloning of a cellular factor, interleukin binding factor, that binds to NFAT-like motifs in the human immunodeficiency virus long terminal repeat.

1991 • 108 citations

Transcellular transactivation by the human immunodeficiency virus type 1 tat protein

1991 • 102 citations

Specific NF-kappa B subunits act in concert with Tat to stimulate human immunodeficiency virus type 1 transcription

1992 • 98 citations

In vitro interaction of the human immunodeficiency virus type 1 Tat transactivator and the general transcription factor TFIIB with the cellular protein TAP

1995 • 93 citations

Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells.

1992 • 92 citations

Evidence for stimulation of the transforming growth factor beta 1 promoter by HIV-1 Tat in cells derived from CNS.

1993 • 88 citations

Sp1 transcription factor is required for in vitro basal and Tat-activated transcription from the human immunodeficiency virus type 1 long terminal repeat

1995 • 85 citations

Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation.

1995 • 79 citations

HIV-1 transactivator protein Tat induces proliferation and TGF beta expression in human articular chondrocytes

1994 • 77 citations

A human binding site for transcription factor USF/MLTF mimics the negative regulatory element of human immunodeficiency virus type 1

1992 • 75 citations

IL-10 Inhibits HIV-1 Replication and Is Induced by Tat

1994 • 69 citations

In vivo footprinting analysis of constitutive and inducible protein-DNA interactions at the long terminal repeat of human immunodeficiency virus type 1

1993 • 69 citations

NF-κ B-Dependent and -Independent Pathways of HIV Activation in a Chronically Infected T Cell Line

1994 • 69 citations

Human immunodeficiency virus Tat induces functional unresponsiveness in T cells

1995 • 59 citations

Human immunodeficiency virus type 1 tat gene up-regulates interleukin 4 receptors on a human B-lymphoblastoid cell line.

1992 • 53 citations

Cooperative inhibition of NF-kappa B and Tat-induced superactivation of human immunodeficiency virus type 1 long terminal repeat.

1993 • 46 citations

Transcriptional trans activation by human immunodeficiency virus type 1 Tat requires specific coactivators that are not basal factors

1995 • 43 citations

Activation of human immunodeficiency virus type 1 provirus in T-cells and macrophages is associated with induction of inducer-specific NF-κB binding proteins

1992 • 37 citations

A rapid procedure for the quantitation of low abundance RNAs by competitive reverse transcription-polymerase chain reaction

1994 • 36 citations

Rapid activation and subsequent down-regulation of the human immunodeficiency virus type 1 promoter in the presence of Tat: possible mechanisms contributing to latency

1991 • 29 citations

Chemically selected subclones of the CEM cell line demonstrate resistance to HIV-1 infection resulting from a selective loss of NF-kappa B DNA binding proteins.

1994 • 26 citations

Probing protein-DNA interactions at the long terminal repeat of human immunodeficiency virus type 1 by in vivo footprinting

1992 • 25 citations

TAR-Independent Activation of HIV-1 Requires the Activation Domain but Not the RNA-Binding Domain of Tat

1993 • 22 citations

Enhanced Activity of Human G6PD Promoter Transfected in HeLa Cells Producing High Levels of HIV-1 Tat

1993 • 21 citations

Rapid Purification of Monomer HIV-2 Tat Protein Expressed in Escherichia coli

1993 • 12 citations