Integrin signaling in leukocytes: lessons from the α6β1 integrin

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Integrins and Signal Transduction Pathways: the Road Taken

1995 • 3,002 citations

Protein modules and signalling networks

1995 • 2,447 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

1994 • 1,590 citations

Traffic Signals on Endothelium for Lymphocyte Recirculation and Leukocyte Emigration

1995 • 1,525 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family

1995 • 1,252 citations

Autophosphorylation of the Focal Adhesion Kinase, ppl25^FAK, Directs SH2-Dependent Binding of pp60^src

1994 • 1,168 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Regulation of cell adhesion and anchorage-dependent growth by a new β1-integrin-linked protein kinase

1996 • 1,106 citations

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho.

1996 • 1,045 citations

On the Crawling of Animal Cells

1993 • 1,020 citations

Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

1993 • 966 citations

Laminin and Other Basement Membrane Components

1987 • 900 citations

Structure and function of laminin: anatomy of a multidomain glycoprotein

1990 • 812 citations

A new nomenclature for the laminins

1994 • 753 citations

Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activity

1991 • 746 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Regulation of Integrin Function by the Urokinase Receptor

1996 • 734 citations

Integrin-mediated cell adhesion activates mitogen-activated protein kinases.

1994 • 660 citations

A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner.

1994 • 653 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Regulated expression and binding of three VLA (β1) integrin receptors on T cells

1990 • 634 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

1994 • 617 citations

Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice

1996 • 599 citations

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

1996 • 595 citations

Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

1994 • 553 citations

pp125^FAK-Dependent Tyrosine Phosphorylation of Paxillin Creates a High-Affinity Binding Site for Crk

1995 • 534 citations

Focal adhesion kinase and associated proteins

1994 • 525 citations

Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins

1989 • 524 citations

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

1994 • 516 citations

Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins

1996 • 494 citations

αLβ2 Integrin/LFA-1 Binding to ICAM-1 Induced by Cytohesin-1, a Cytoplasmic Regulatory Molecule

1996 • 439 citations

Binding of Transforming Protein, P47 ^gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

1990 • 433 citations

Induction of p130^cas Signaling Complex Formation upon Integrin-Mediated Cell Adhesion: a Role for Src Family Kinases

1996 • 422 citations

Integrin-dependent activation of MAP kinase: a link to shape-dependent cell proliferation.

1995 • 415 citations

Integrin Activation by R-ras

1996 • 414 citations

Adherence induces selective mRNA expression of monocyte mediators and proto-oncogenes.

1988 • 411 citations

The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases.

1995 • 410 citations

Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins.

1990 • 391 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

Deficiency of Src family kinases p59/61hck and p58c-fgr results in defective adhesion-dependent neutrophil functions.

1996 • 364 citations

p130Cas, a Substrate Associated with v-Src and v-Crk, Localizes to Focal Adhesions and Binds to Focal Adhesion Kinase

1996 • 364 citations

Specific and redundant roles of Src and Fyn in organizing the cytoskeleton

1995 • 325 citations

Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures.

1984 • 324 citations

Basal lamina assembly

1994 • 322 citations

Altered distributions of the cytoskeletal proteins vinculin and alpha-actinin in cultured fibroblasts transformed by Rous sarcoma virus.

1980 • 296 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

The activation dependent adhesion of macrophages to laminin involves cytoskeletal anchoring and phosphorylation of the alpha 6 beta 1 integrin.

1990 • 288 citations

Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44erk-1 and p42erk-2

1995 • 274 citations

Characterization of novel complexes on the cell surface between integrins and proteins with 4 transmembrane domains (TM4 proteins).

1996 • 274 citations

Rho: a connection between membrane receptor signalling and the cytoskeleton

1996 • 271 citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

1995 • 237 citations

Integrin-mediated Tyrosine Phosphorylation and Cytokine Message Induction in Monocytic Cells

1995 • 228 citations

Laminin receptors: achieving specificity through cooperation

1995 • 225 citations

The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110.

1991 • 224 citations

Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction.

1992 • 218 citations

Transendothelial migration of neutrophils involves integrin-associated protein (CD47).

1995 • 217 citations

Insulin stimulates the tyrosine phosphorylation of caveolin.

1995 • 215 citations

Tyrosine kinase activity, cytoskeletal organization, and motility in human vascular endothelial cells.

1994 • 214 citations

Rac mediates growth factor-induced arachidonic acid release

1995 • 207 citations

The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes.

1996 • 196 citations

Crosslinking of the T cell-specific accessory molecules CD7 and CD28 modulates T cell adhesion.

1992 • 194 citations

Involvement of rho in GTPγS‐induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity

1995 • 187 citations

Beta 3-endonexin, a novel polypeptide that interacts specifically with the cytoplasmic tail of the integrin beta 3 subunit.

1995 • 187 citations

Integrin-mediated Activation of MEK and Mitogen-activated Protein Kinase Is Independent of Ras

1996 • 187 citations

alpha-Actinin and vinculin are PIP2-binding proteins involved in signaling by tyrosine kinase.

1994 • 186 citations

The three faces of profilin

1993 • 179 citations

Steel factor and c-kit regulate cell-matrix adhesion

1994 • 178 citations

Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils.

1994 • 174 citations

Cytosolic Phospholipase A2 Is Phosphorylated in Collagen- and Thrombin-stimulated Human Platelets Independent of Protein Kinase C and Mitogen-activated Protein Kinase

1995 • 172 citations

Stable Association of Activated pp60^src with Two Tyrosine-Phosphorylated Cellular Proteins

1989 • 168 citations

Ras Activation Is Necessary for Integrin-mediated Activation of Extracellular Signal-regulated Kinase 2 and Cytosolic Phospholipase A2 but Not for Cytoskeletal Organization

1996 • 167 citations

Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin

1996 • 152 citations

The urokinase receptor

1994 • 151 citations

Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase

1996 • 137 citations

Inducible Interaction of Integrin α2β1 with Calreticulin

1995 • 137 citations

Differential Activation of Cytosolic Phospholipase A2 (cPLA2) by Thrombin and Thrombin Receptor Agonist Peptide in Human Platelets. EVIDENCE FOR ACTIVATION OF cPLA2 INDEPENDENT OF THE MITOGEN-ACTIVATED PROTEIN KINASES ERK1/2

1995 • 126 citations

Human neutrophil adherence to laminin in vitro. Evidence for a distinct neutrophil integrin receptor for laminin.

1990 • 122 citations

The role of protein tyrosine phosphorylation in integrin-mediated gene induction in monocytes.

1994 • 117 citations

A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen.

1995 • 111 citations

Integrin αvβ5-dependent Serine Phosphorylation of Paxillin in Cultured Human Macrophages Adherent to Vitronectin

1996 • 110 citations

Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways

1995 • 108 citations

Potential role for focal adhesion kinase in migrating and proliferating keratinocytes near epidermal wounds and in culture.

1994 • 100 citations

The identification of p130cas-binding proteins and their role in cellular transformation.

1996 • 98 citations

Structure and Function of Laminin

1993 • 96 citations

Macrophage interactions with laminin: PMA selectively induces the adherence and spreading of mouse macrophages on a laminin substratum.

1988 • 86 citations

Inside-out integrin signaling in macrophages. Analysis of the role of the alpha 6A beta 1 and alpha 6B beta 1 integrin variants in laminin adhesion by cDNA expression in an alpha 6 integrin-deficient macrophage cell line

1993 • 86 citations

v-Src-induced degradation of focal adhesion kinase during morphological transformation of chicken embryo fibroblasts.

1995 • 83 citations

The Src and Csk families of tyrosine protein kinases in hemopoietic cells

1995 • 75 citations

Spreading of HeLa cells on a collagen substratum requires a second messenger formed by the lipoxygenase metabolism of arachidonic acid released by collagen receptor clustering.

1992 • 71 citations

Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages.

1994 • 68 citations

Laminin And Other Basement Membrane Components

1987 • 67 citations

Fimbrin localized to an insoluble cytoskeletal fraction is constitutively phosphorylated on its headpiece domain in adherent macrophages

1993 • 63 citations

The α6Aβ1 and α6Bβ1 Integrin Variants Signal Differences in the Tyrosine Phosphorylation of Paxillin and Other Proteins

1995 • 60 citations

Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit.

1993 • 60 citations

An Examination of Focal Adhesion Formation and Tyrosine Phosphorylation in Fibroblasts Isolated from src¯, fyn¯, and yes¯ Mice

1995 • 59 citations

Beta 1 integrins signal lipid second messengers required during cell adhesion.

1995 • 54 citations

Interferon gamma and lipopolysaccharide promote macrophage adherence to basement membrane glycoproteins.

1989 • 50 citations

Identification of major tyrosine-phosphorylated proteins in Csk-deficient cells.

1994 • 48 citations

Lymphocyte antigen receptor activation of a focal adhesion kinase-related tyrosine kinase substrate.

1994 • 47 citations

CD28 signal transduction: tyrosine phosphorylation and receptor association of phosphoinositide‐3 kinase correlate with Ca²⁺‐independent costimulatory activity

1994 • 42 citations

ADP‐ribosylation of Rho enhances adhesion of U937 cells to fibronectin via the α5β1 integrin receptor

1995 • 33 citations

T cell activation via the CD2 molecule is associated with protein kinase C translocation from the cytosol to the plasma membrane

1989 • 32 citations

ADP‐ribosylation of Rho enhances actin polymerization‐coupled shape oscillations in human neutrophils

1995 • 25 citations

Differential distribution of two cytoplasmic variants of the α6β1 integrin laminin receptor in the ventral plasma membrane of embryonic fibroblasts

1995 • 24 citations

Reduced Phospholipase A2 Activity Is Not Accompanied by Reduced Arachidonic Acid Release

1994 • 12 citations

Deleted Work

1955 • 0 citations