High-affinity epidermal growth factor binding is specifically reduced by a monoclonal antibody, and appears necessary for early responses.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Data Reduction and Error Analysis for the Physical Sciences

1969 • 13,865 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Epidermal Growth Factor

1979 • 2,964 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor

1987 • 624 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors

1979 • 517 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Signal transduction by allosteric receptor oligomerization

1988 • 410 citations

Human epidermal growth factor and the proliferation of human fibroblasts

1976 • 403 citations

Allosteric regulation of the epidermal growth factor receptor kinase.

1986 • 381 citations

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbb protein

1985 • 310 citations

Efficacy of Antibodies to Epidermal Growth Factor Receptor Against KB Carcinoma In Vitro and in Nude Mice

1988 • 240 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

Regulation of Cell Proliferation by Epidermal Growth Factor

1983 • 235 citations

Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent.

1988 • 228 citations

Reconstitution of human epidermal growth factor receptors and its deletion mutants in cultured hamster cells.

1986 • 222 citations

A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction.

1988 • 215 citations

Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding.

1987 • 209 citations

Signal transduction by epidermal growth factor occurs through the subclass of high affinity receptors.

1989 • 200 citations

Functional analysis of the ligand binding site of EGF-receptor utilizing chimeric chicken/human receptor molecules.

1989 • 197 citations

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

1987 • 186 citations

Epidermal Growth Factor (Urogastrone) in Human Tissues*

1979 • 182 citations

Chicken epidermal growth factor (EGF) receptor: cDNA cloning, expression in mouse cells, and differential binding of EGF and transforming growth factor alpha.

1988 • 178 citations

Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.

1988 • 161 citations

Relationship between epidermal growth factor receptor occupancy and mitogenic response. Quantitative analysis using a steady state model system.

1984 • 149 citations

Contrasting interleukin 2 binding properties of the alpha (p55) and beta (p70) protein subunits of the human high-affinity interleukin 2 receptor.

1987 • 147 citations

Plasma Concentrations of Immunoreactive Human Epidermal Growth Factor (Urogastrone) in Man*

1980 • 127 citations

Characterization of the receptor for epidermal growth factor-urogastrone in human placenta membranes.

1980 • 126 citations

Effect of nonspecific forces and finite receptor number on rate constants of ligand--cell bound-receptor interactions.

1981 • 110 citations

Two alternative mechanisms control the interconversion of functional states of the epidermal growth factor receptor.

1988 • 93 citations

Inhibition of human tumor growth in nude mice by a conjugate of doxorubicin with monoclonal antibodies to epidermal growth factor receptor.

1989 • 62 citations

Epidermal-growth-factor-induced formation of inositol phosphates in human A431 cells. Differences from the effect of bradykinin

1988 • 57 citations

Chicken Epidermal Growth Factor (EGF) Receptor: cDNA Cloning, Expression in Mouse Cells, and Differential Binding of EGF and Transforming Growth Factor Alpha

1988 • 50 citations

Protein Kinase C Inhibition of the Epidermal Growth Factor Receptor Tyrosine Protein Kinase Activity is Independent of the Oligomeric State of the Receptor

1989 • 35 citations