Epidermal Growth Factor Receptor Interaction with Clathrin Adaptors Is Mediated by the Tyr974-containing Internalization Motif

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

125I-labeled human epidermal growth factor. Binding, internalization, and degradation in human fibroblasts.

1976 • 1,293 citations

Interaction of Tyrosine-Based Sorting Signals with Clathrin-Associated Proteins

1995 • 955 citations

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

1985 • 849 citations

Signal-Dependent Membrane Protein Trafficking in the Endocytic Pathway

1993 • 808 citations

Clathrin, Adaptors, and Sorting

1990 • 704 citations

Internalization and processing of transferrin and the transferrin receptor in human carcinoma A431 cells.

1983 • 636 citations

Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.

1979 • 528 citations

Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts

1983 • 445 citations

Receptors compete for adaptors found in plasma membrane coated pits.

1988 • 366 citations

Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.

1978 • 358 citations

Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts.

1984 • 357 citations

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

1989 • 356 citations

The role of clathrin, adaptors and dynamin in endocytosis

1994 • 343 citations

Specificity of binding of clathrin adaptors to signals on the mannose-6-phosphate/insulin-like growth factor II receptor.

1989 • 336 citations

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

1984 • 295 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

Endocytosis of growth factor receptors

1993 • 277 citations

Interaction of Activated EGF Receptors with Coated Pit Adaptins

1993 • 259 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

1990 • 207 citations

Kinetics of transit of transferrin and epidermal growth factor through clathrin-coated membranes

1984 • 174 citations

Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.

1993 • 155 citations

Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain

1995 • 151 citations

Multiple autophosphorylation sites of the epidermal growth factor receptor are essential for receptor kinase activity and internalization. Contrasting significance of tyrosine 992 in the native and truncated receptors.

1992 • 150 citations

Recruitment of epidermal growth factor receptors into coated pits requires their activated tyrosine kinase.

1995 • 147 citations

Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions.

1994 • 145 citations

The basolateral targeting signal in the cytoplasmic domain of glycoprotein G from vesicular stomatitis virus resembles a variety of intracellular targeting motifs related by primary sequence but having diverse targeting activities.

1994 • 127 citations

Stoichiometric Interaction of the Epidermal Growth Factor Receptor with the Clathrin-associated Protein Complex AP-2

1995 • 119 citations

In vitro binding of plasma membrane-coated vesicle adaptors to the cytoplasmic domain of lysosomal acid phosphatase

1993 • 114 citations

100-kDa polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis.

1989 • 110 citations

In vitro binding of the asialoglycoprotein receptor to the beta adaptin of plasma membrane coated vesicles.

1991 • 102 citations

Clathrin polymerization is not required for bulk-phase endocytosis in rat fetal fibroblasts.

1994 • 102 citations

Kinetics of binding, endocytosis, and recycling of EGF receptor mutants

1992 • 100 citations

Association of Epidermal Growth Factor Receptors with Coated Pit Adaptins via a Tyrosine Phosphorylation-regulated Mechanism

1995 • 98 citations

Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins.

1995 • 89 citations

Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines

1991 • 88 citations

Cytosol- and clathrin-dependent stimulation of endocytosis in vitro by purified adaptors.

1992 • 84 citations

Roles for a Cytoplasmic Tyrosine and Tyrosine Kinase Activity in the Interactions of Neu Receptors with Coated Pits

1995 • 77 citations

Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements.

1993 • 76 citations

The internalization signal in the cytoplasmic tail of lysosomal acid phosphatase consists of the hexapeptide PGYRHV.

1992 • 69 citations

Role of the regulatory domain of the EGF-receptor cytoplasmic tail in selective binding of the clathrin-associated complex AP-2

1995 • 67 citations

Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation.

1989 • 54 citations

SHC and GRB-2 Are Constitutively Activated by an Epidermal Growth Factor Receptor with a Point Mutation in the Transmembrane Domain

1995 • 42 citations

Lysosomal acid phosphatase is internalized via clathrin-coated pits.

1992 • 25 citations

Analysis of the influences of the E5 transforming protein on kinetic parameters of epidermal growth factor binding and metabolism

1992 • 21 citations

What Do We Learn from Neutrinos?

1993 • 2 citations