The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1998 • 865 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Survival of mononuclear phagocytes depends on a lineage-specific growth factor that the differentiated cells selectively destroy

1982 • 671 citations

Encyclopedia of immunology

1999 • 468 citations

The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway

1996 • 397 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.

1989 • 316 citations

Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease

1996 • 316 citations

The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor.

1996 • 307 citations

Similarity of sli-1 , a Regulator of Vulval Development in C. elegans , to the Mammalian Proto-Oncogene c- cbl

1995 • 298 citations

A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

1998 • 283 citations

Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1)

1981 • 274 citations

Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins

1997 • 270 citations

The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor α

1998 • 257 citations

The Product of the Proto-Oncogene c- cbl : A Negative Regulator of the Syk Tyrosine Kinase

1997 • 251 citations

[42] The macrophage colony-stimulating factor, CSF-1

1985 • 232 citations

Degradation of the Met Tyrosine Kinase Receptor by the Ubiquitin-Proteasome Pathway

1997 • 221 citations

The interaction of 125I-colony-stimulating factor-1 with bone marrow-derived macrophages.

1986 • 205 citations

Identification of a novel ubiquitin conjugation motif, required for ligand-induced internalization of the growth hormone receptor

1999 • 194 citations

Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.

1995 • 185 citations

Ubiquitination of the yeast a-factor receptor.

1996 • 172 citations

c-Cbl Is Transiently Tyrosine-phosphorylated, Ubiquitinated, and Membrane-targeted following CSF-1 Stimulation of Macrophages

1996 • 163 citations

Colony-stimulating factor (CSF) radioimmunoassay: detection of a CSF subclass stimulating macrophage production.

1979 • 162 citations

sli-1, a negative regulator of let-23-mediated signaling in C. elegans.

1995 • 149 citations

Role of dimerization and modification of the CSF-1 receptor in its activation and internalization during the CSF-1 response.

1991 • 143 citations

Degradation Process of Ligand-stimulated Platelet-derived Growth Factor β -Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway

1995 • 139 citations

The epidermal growth factor receptor is covalently linked to ubiquitin.

1995 • 130 citations

unc-101, a gene required for many aspects of Caenorhabditis elegans development and behavior, encodes a clathrin-associated protein.

1994 • 126 citations

Protein tyrosine phosphatase-1C is rapidly phosphorylated in tyrosine in macrophages in response to colony stimulating factor-1.

1992 • 124 citations

Purification of the colony-stimulating factor 1 receptor and demonstration of its tyrosine kinase activity.

1987 • 123 citations

Interactions of Drosophila Cbl with Epidermal Growth Factor Receptors and Role of Cbl in R7 Photoreceptor Cell Development

1997 • 123 citations

A Role for CAP, a Novel, Multifunctional Src Homology 3 Domain-containing Protein in Formation of Actin Stress Fibers and Focal Adhesions

1998 • 116 citations

The c-cbl proto-oncogene is preferentially expressed in thymus and testis tissue and encodes a nuclear protein

1989 • 115 citations

Identification and subcellular localization of proteins that are rapidly phosphorylated in tyrosine in response to colony-stimulating factor 1.

1988 • 110 citations

Murine bone marrow-derived macrophages.

1990 • 96 citations

CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins

1999 • 90 citations

The Cbl Protooncogene Product: From an Enigmatic Oncogene to Center Stage of Signal Transduction

1997 • 88 citations

The protein product of the c-cbl oncogene rapidly complexes with the EGF receptor and is tyrosine phosphorylated following EGF stimulation.

1995 • 76 citations

Antisense Repression of Proto-oncogene c-Cbl Enhances Activation of the JAK-STAT Pathway but Not the Ras Pathway in Epidermal Growth Factor Receptor Signaling

1997 • 74 citations

The Cbl Family of Signal Transduction Molecules

1997 • 67 citations

D-Cbl, the Drosophila homologue of the c-Cbl proto-oncogene, interacts with the Drosophila EGF receptor in vivo, despite lacking C-terminal adaptor binding sites

1997 • 66 citations

Regulation of p21ras activity

1991 • 60 citations

Ligand-Induced Polyubiquitination of Receptor Tyrosine Kinases

1995 • 58 citations

Regulation of β1-integrin-mediated cell adhesion by the CbI adaptor protein

1998 • 57 citations

Identification of Tyrosine 706 in the Kinase Insert as the Major Colony-Stimulating Factor 1 (CSF-1)-Stimulated Autophosphorylation Site in the CSF-1 Receptor in a Murine Macrophage Cell Line

1990 • 53 citations

Tyrosine phosphorylation of a common 57-kDa protein in growth factor-stimulated and -transformed cells.

1991 • 52 citations

The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway

1996 • 49 citations

v-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP-kinase activation.

1993 • 48 citations

Phosphatidylcholine Hydrolysis and c-myc Expression Are in Collaborating Mitogenic Pathways Activated by Colony-Stimulating Factor 1

1993 • 44 citations

Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages

1996 • 41 citations

Complementation of Growth Factor Receptor-Dependent Mitogenic Signaling by a Truncated Type I Phosphatidylinositol 4-Phosphate 5-Kinase

1997 • 36 citations

CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2

1997 • 31 citations

Uptake and destruction of ¹²⁵I‐CSF‐1 by peritoneal exudate macrophages

1986 • 26 citations

Increased phosphorylation of the colony stimulating factor-1 receptor following transmembrane signaling.

1991 • 19 citations

Phosphatidylcholine hydrolysis and c-myc expression are in collaborating mitogenic pathways activated by colony-stimulating factor 1.

1993 • 18 citations

Regulation of p21ras activity

1991 • 18 citations

Macrophage Colony-Stimulating Factor (CSF-1)

1998 • 1 citations