Synergy between Ca2+ and protein kinase C is the major factor in determining the level of secretion from human platelets

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The role of protein kinase C in cell surface signal transduction and tumour promotion

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Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

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1985 • 340 citations

Phorbol ester-induced activation of human platelets is associated with protein kinase C phosphorylation of myosin light chains

1983 • 265 citations

Molecular cloning and expression of the major protein kinase C substrate of platelets

1988 • 250 citations

Identification, phosphorylation, and dephosphorylation of a second site for myosin light chain kinase on the 20,000-dalton light chain of smooth muscle myosin.

1986 • 246 citations

Evidence for a role of myosin phosphorylation in the initiation of the platelet shape change response.

1984 • 223 citations

The action of the protein kinase C inhibitor, staurosporine, on human platelets. Evidence against a regulatory role for protein kinase C in the formation of inositol trisphosphate by thrombin

1988 • 218 citations

Purification and characterization of the 47,000-dalton protein phosphorylated during degranulation of human platelets.

1983 • 179 citations

Isolation and properties of platelet myosin light chain kinase

1976 • 111 citations

A diacylglycerol kinase inhibitor, R59022, potentiates secretion by and aggregation of thrombin-stimulated human platelets

1987 • 79 citations

Different translocation of three distinct PKC isoforms with tumor-promoting phorbol ester in human platelets

1991 • 76 citations

Ca2+ mobilization primes protein kinase C in human platelets. Ca2+ and phorbol esters stimulate platelet aggregation and secretion synergistically through protein kinase C.

1988 • 75 citations

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1986 • 59 citations

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