Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1985 • 471 citations

Adsorption of divalent cations to bilayer membranes containing phosphatidylserine.

1981 • 418 citations

Decrease in cytosolic calcium/phospholipid-dependent protein kinase activity following phorbol ester treatment of EL4 thymoma cells.

1982 • 417 citations

Isozymic forms of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 389 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Cooperative roles of various membrane phospholipids in the activation of calcium-activated, phospholipid-dependent protein kinase.

1981 • 367 citations

Expression, purification, and characterization of protein kinase C-epsilon.

1990 • 231 citations

The nature of protein kinase C activation by physically defined phospholipid vesicles and diacylglycerols.

1985 • 228 citations

Visualization of proteins with a silver “stain”: A critical analysis

1981 • 223 citations

Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

1984 • 209 citations

Autophosphorylation of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 183 citations

Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation

1987 • 168 citations

Association of protein kinase C with phospholipid vesicles

1987 • 149 citations

Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes

1991 • 139 citations

Effects of phorbol esters, diglyceride, and cholinergic agonists on the subcellular distribution of protein kinase C in intact or digitonin-permeabilized adrenal chromaffin cells.

1986 • 134 citations

Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine.

1986 • 127 citations

Lipid phase separation induced by a hydrophobic protein in phosphatidylserine-phosphatidylcholine vesicles

1977 • 124 citations

Expression of the alpha, beta II, and gamma protein kinase C isozymes in the baculovirus-insect cell expression system. Purification and characterization of the individual isoforms.

1990 • 120 citations

Properties of membrane-inserted protein kinase C

1988 • 119 citations

On the nature of calcium ion binding between phosphatidylserine lamellae

1986 • 118 citations

Protein kinase C interaction with calcium: a phospholipid-dependent process

1990 • 116 citations

High Cooperativity, Specificity, and Multiplicity in the Protein Kinase C-Lipid Interaction

1989 • 116 citations

Phospholipid Functional Groups Involved in Protein Kinase C Activation, Phorbol Ester Binding, and Binding to Mixed Micelles

1989 • 115 citations

Extensive segregation of acidic phospholipids in membranes induced by protein kinase C and related proteins

1991 • 97 citations

Protein kinase C autophosphorylates by an intrapeptide reaction.

1987 • 83 citations

Characterization of mixed micelles of phospholipids of various classes and a synthetic, homogeneous analogue of the nonionic detergent triton X-100 containing nine oxyethylene groups

1978 • 77 citations

Phosphatidylserine affects specificity of protein kinase C substrate phosphorylation and autophosphorylation

1990 • 67 citations

Intermembrane contact affects calcium binding to phospholipid vesicles.

1982 • 66 citations

Association of protein kinase C with phospholipid monolayers: two-stage irreversible binding

1988 • 66 citations

IL-1 signaling for IL-2 production in T cells involves a rise in phosphatidylserine synthesis.

1988 • 54 citations

Site-site interaction in the phospholipid activation of D-beta-hydroxybutyrate dehydrogenase.

1986 • 46 citations

Distribution of phospholipids around gramicidin and D-.beta.-hydroxybutyrate dehydrogenase as measured by resonance energy transfer

1988 • 41 citations

Lipid solvation and kinetic cooperativity of functional membrane proteins

1983 • 35 citations

Phorbol ester inhibits phosphatidylserine synthesis in human promyelocytic leukaemia HL60 cells. Possible involvement of free radicals and correlation with phosphorylation of nuclear protein 1b

1987 • 25 citations

Cooperativity in lipid activation of 3-hydroxybutyrate dehydrogenase: role of lecithin as an essential allosteric activator

1989 • 15 citations

Altered distribution of protein kinase C in dystrophic muscle cells and its modulation by liposome-delivered phospholipids

1986 • 14 citations