IL-4-Induced GATA-3 Expression Is a Time-Restricted Instruction Switch for Th2 Cell Differentiation

The language of covalent histone modifications

2000 • 8,260 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

Signaling to Chromatin through Histone Modifications

2000 • 987 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

2000 • 793 citations

Rapid and Phosphoinositol-Dependent Binding of the SWI/SNF-like BAF Complex to Chromatin after T Lymphocyte Receptor Signaling

1998 • 719 citations

Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation

1998 • 697 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Signaling and Transcription in T Helper Development

2000 • 635 citations

Lineage commitment in the immune system: the T helper lymphocyte grows up

2000 • 627 citations

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

2002 • 517 citations

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

2001 • 497 citations

Gata-3 Induces T Helper Cell Type 2 (Th2) Cytokine Expression and Chromatin Remodeling in Committed Th1 Cells

2000 • 390 citations

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

1999 • 377 citations

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation

2002 • 334 citations

Ectopic Expression of Activated Stat6 Induces the Expression of Th2-Specific Cytokines and Transcription Factors in Developing Th1 Cells

1999 • 300 citations

Delayed Lymphoid Repopulation with Defects in IL-4–Driven Responses Produced by Inactivation of NF-ATc

1998 • 298 citations

Acetylation and chromosomal functions

2000 • 296 citations

Cell-Type-Restricted Binding of the Transcription Factor NFAT to a Distal IL-4 Enhancer In Vivo

2000 • 270 citations

Differences between IL-4- and IL-4 receptor alpha-deficient mice in chronic leishmaniasis reveal a protective role for IL-13 receptor signaling.

1999 • 249 citations

Transcription

2002 • 241 citations

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

2002 • 212 citations

Growth Factor Independent-1 Induced by IL-4 Regulates Th2 Cell Proliferation

2002 • 207 citations

Differences Between IL-4- and IL-4 Receptor α-Deficient Mice in Chronic Leishmaniasis Reveal a Protective Role for IL-13 Receptor Signaling

1999 • 204 citations

Deletion of a coordinate regulator of type 2 cytokine expression in mice

2001 • 196 citations

Identification of a Conserved GATA3 Response Element Upstream Proximal from the Interleukin-13 Gene Locus

2002 • 194 citations

Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

1999 • 190 citations

Down-Regulation of IL-4 Gene Transcription and Control of Th2 Cell Differentiation by a Mechanism Involving NFAT1

1997 • 176 citations

Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region.

1998 • 139 citations

NF-AT-Driven Interleukin-4 Transcription Potentiated by NIP45

1996 • 136 citations

T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6

1997 • 133 citations

A 3′ Enhancer in the IL-4 Gene Regulates Cytokine Production by Th2 Cells and Mast Cells

2002 • 117 citations

NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription

2002 • 112 citations

An Instructive Component in T Helper Cell Type 2 (Th2) Development Mediated by Gata-3

2001 • 111 citations

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells

1998 • 94 citations

CD28 Costimulation Accelerates IL-4 Receptor Sensitivity and IL-4-Mediated Th2 Differentiation

1999 • 78 citations

T cell differentiation: a mechanistic view

2000 • 77 citations

Cytokines and T cells in host defense

2000 • 75 citations

Cell Division Is Not a “Clock” Measuring Acquisition of Competence to Produce IFN-γ or IL-4

2001 • 74 citations

Helper T cell differentiation, inside and out

2001 • 62 citations

Chromatin-based regulatory mechanisms governing cytokine gene transcription

1999 • 55 citations

Bi-stable Transcriptional Circuitry and GATA-3 Auto-activation in Th2 Commitment

1999 • 10 citations