Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.

1981 • 14,396 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue

1955 • 4,109 citations

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

1982 • 3,563 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Greenfield's Neuropathology

1985 • 1,149 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

1984 • 820 citations

Subcellular Particles

1959 • 799 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

共やくエクイン・エストロゲン(Premarin)服用閉経婦人の血清エクイリン,エストロン,エストラジオール値

1980 • 725 citations

DEFECTIVE BRAIN MICROTUBULE ASSEMBLY IN ALZHEIMER'S DISEASE

1986 • 704 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

1987 • 602 citations

Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

1993 • 575 citations

Cell death: a new classification separating apoptosis from necrosis

1981 • 575 citations

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

1993 • 430 citations

A NEW DEFINITION OF ALZHEIMER'S DISEASE: A HIPPOCAMPAL DEMENTIA

1985 • 422 citations

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

1990 • 415 citations

Quantitative synaptic alterations in the human neocortex during normal aging

1993 • 408 citations

Free radicals, aging, and degenerative diseases

1987 • 375 citations

One of the Antigenic Determinants of Paired Helical Filaments Is Related to Tau Protein1

1986 • 336 citations

Free radicals, aging, and degenerative diseases

1986 • 311 citations

Cortical neuronal counts in normal elderly controls and demented patients

1983 • 293 citations

Inhibitors of Lysosomal Enzymes: Accumulation of Lipofuscin-Like Dense Bodies in the Brain

1984 • 274 citations

A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis

1992 • 270 citations

The noradrenergic system in Alzheimer and multi-infarct dementias.

1982 • 177 citations

Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal origin

1990 • 168 citations

LIPOPROTEIN PIGMENTS—THEIR RELATIONSHIP TO AGEING IN THE HUMAN NERVOUS SYSTEM

1974 • 159 citations

The relationship between lipofuscin pigment and ageing in the human nervous system

1978 • 143 citations

Alzheimer's disease: Advances in clinical and basic research

1994 • 134 citations

Cell death in biology and pathology

1982 • 131 citations

Quantitative study on dendrites and dendritic spines in Alzheimer's disease and senile dementia.

1975 • 129 citations

Fluorescent pigment accumulation in retinal pigment epithelium of antioxidant-deficient rats.

1978 • 128 citations

Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's disease

1985 • 127 citations

Altered Calcium Signaling and Neuronal Injury: Stroke and Alzheimer's Disease as Examples

1993 • 111 citations

Neurochemical aspects of Alzheimer's disease: Involvement of membrane phospholipids

1988 • 108 citations

Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease

1991 • 108 citations

Platelet membrane fluidity in Alzheimer's disease and major depression

1987 • 106 citations

The Lysosomal System in Neurons

1992 • 102 citations

Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles.

1991 • 98 citations

THE QUANTITATIVE ASSESSMENT OF LIPOFUSCIN PIGMENT, CYTOPLASMIC RNA AND NUCLEOLAR VOLUME IN SENILE DEMENTIA

1978 • 88 citations

Lysosome and phagosome stability in lethal cell injury. Morphologic tracer studies in cell injury due to inhibition of energy metabolism, immune cytolysis and photosensitization.

1972 • 86 citations

The Advances in Neurobiology

2016 • 86 citations

The Lysosomal System in Neuronal Cell Death: A Review^a

1993 • 83 citations

Aging and the alteration of enzymes: A review

1975 • 83 citations

Disappearance of Rohon‐Beard neurons from the spinal cord of larval Xenopus laevis

1987 • 81 citations

The Deposition of Aging Pigment in the Human Cerebral Cortex

1960 • 80 citations

Age-related increase in a cathepsin D-like protease that degrades brain microtubule-associated proteins

1987 • 80 citations

Calcium, membranes, aging, and Alzheimer's disease

1989 • 77 citations

Lysosome instability in aged rat brain

1989 • 71 citations

Accumulation of amyloid precursor fragment in Alzheimer plaques

1991 • 67 citations

Electron microscopic studies on the lipo-pigments in the cerebral cortex nerve cells of senile and vitamin E deficient rats

1967 • 66 citations

Free radical theory of aging: A hypothesis on pathogenesis of senile dementia of the Alzheimer’s type

1993 • 64 citations

Molecular Insights into Alzheimer's Disease

1989 • 62 citations

Factors affecting the lysosomal membrane and availability of enzymes

1964 • 62 citations

Increase in cathepsin D activity in rat brain in aging

1989 • 58 citations

Alzheimer’s Disease and Cellular Aging: Membrane-Related Events as Clues to Primary Mechanisms

1991 • 55 citations

Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease

1990 • 54 citations

Quantitative studies of the autofluorescence derived from neuronal lipofuscin

1981 • 54 citations

Immunodetection of cathepsin D in neuritic plaques found in brains of patients with dementia of Alzheimer type.

1989 • 53 citations

Abnormal and deficient processing of β-amyloid precursor protein in familial Alzheimer's disease lymphoblastoid cells

1991 • 42 citations

Lipofuscin: Intra- and Extraneuronal Accumulation and Regional Distribution

1975 • 32 citations

Free radicals, proteolysis, and the degeneration of neurons in alzheimer disease: How essential is the β-amyloid link?

1994 • 30 citations

Markers of neuronal injury and degeneration

1993 • 29 citations

Spindle-shaped appendages of IIIab-pyramids filled with lipofuscin: A striking pathological change of the senescent human isocortex

1979 • 26 citations

Lipofuscin in Amyotrophic Lateral Sclerosis

1984 • 20 citations

Electron microscopical appearance of neuronal lipofuscin using different preparative techniques including freeze-etching

1972 • 19 citations

Are lysosomal enzymes involved in rapid damage in vertebrate muscle cells?

1988 • 17 citations

Lysosomal proteinases as putative diagnostic tools in human neuropathology: Alzheimer disease (AD) and schizophrenia.

1992 • 14 citations

Acid phosphatase activity in human neuronal and glial lipofuscin

1984 • 10 citations

Lysosomal acid hydrolase activities in the aging heart

1980 • 7 citations