Amyloid β protein (Aβ) removal by neuroglial cells in culture

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

1988 • 2,754 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

1987 • 806 citations

A Dissection and tissue culture manual of the nervous system

1989 • 762 citations

Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease

1988 • 702 citations

Peptide Compositions of the Cerebrovascular and Senile Plaque Core Amyloid Deposits of Alzheimer′s Disease

1993 • 489 citations

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

1988 • 410 citations

Rapid Communication: Characterization of β‐Amyloid Peptide from Human Cerebrospinal Fluid

1993 • 383 citations

An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

1994 • 304 citations

Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain

1989 • 281 citations

Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce ?-amyloid fibrils

1992 • 267 citations

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

1990 • 238 citations

Ultrastructural Studies of the Cells Forming Amyloid Fibers in Classical Plaques

1989 • 238 citations

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

1992 • 231 citations

Research advances in Alzheimer's disease and related disorders

1995 • 230 citations

Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses

1989 • 211 citations

Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

1992 • 161 citations

β-Amyloid of Alzheimer's Disease Induces Reactive Gliosis That Inhibits Axonal Outgrowth

1993 • 148 citations

Astrocytes in Alzheimer's disease gray matter express alpha 1-antichymotrypsin mRNA.

1989 • 141 citations

pH‐Dependent Binding of Synthetic β‐Amyloid Peptides to Glycosaminoglycans

1993 • 140 citations

Identification of FcγRI, II and III on normal human brain ramified microglia and on microglia in senile plaques in Alzheimer's disease

1993 • 105 citations

Identification of two benzodiazepine binding sites on cells cultured from rat cerebral cortex.

1981 • 102 citations

Immunohistochemical localization of beta‐amyloid precursor protein sequences in Alzheimer and normal brain tissue by light and electron microscopy

1992 • 88 citations

β-Amyloid peptides induce degeneration of cultured rat microglia

1993 • 82 citations

Inability to Detect β-Amyloid Protein Precursor mRNA in Alzheimer Plaque-Associated Microglia

1993 • 32 citations

Processing of the β-amyloid precursor protein carrying the familial, Dutch-type, and a novel recombinant C-terminal mutation

1993 • 29 citations

Identification of putative high affinity nicotinic receptors on cultured cortical neurons.

1988 • 19 citations

PROCESSING OF NEURONALLY-GENERATED ßAPP BY MACROPHAGES AND MICROGLIA

1993 • 4 citations