Chloroquine administration in mice increases β-amyloid immunoreactivity and attenuates kainate-induced blood–brain barrier dysfunction

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

Mechanism of action of hydroxychloroquine as an antirheumatic drug

1993 • 412 citations

Tight junctions of brain endothelium in vitro are enhanced by astroglia

1987 • 389 citations

Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.

1992 • 202 citations

Ammonia-induced astrocyte swelling in primary culture

1991 • 184 citations

A morphometric study of the blood-brain barrier in Alzheimer's disease.

1992 • 148 citations

Evidence for lysosomal processing of amyloid ?-protein precursor in cultured cells

1989 • 114 citations

Serum amyloid P immunoreactivity in hippocampal tangles, plaques and vessels: implications for leakage across the blood-brain barrier in Alzheimer's disease

1990 • 82 citations

Chloroquine inhibits intracellular segradation but not decretion of Alzheimerβ/A4 amyloid precursor protein.

1992 • 80 citations

Induction of β-Amyloid-Containing Polypeptides in Hippocampus: Evidence for a Concomitant Loss of Synaptic Proteins and Interactions with an Excitotoxin

1994 • 72 citations

Expression of the human beta-amyloid protein of Alzheimer's disease specifically in the brains of transgenic mice.

1991 • 64 citations

A one-step immunohistochemical method for detection of blood—brain barrier disturbances for immunoglobulins in lesioned rat brain with special reference to false-positive labelling in immunohistochemistry

1993 • 52 citations

Amyloid β‐Protein Induces the Cerebrovascular Cellular Pathology of Alzheimer's Disease and Related Disordersa

1996 • 45 citations

Foreign and endogenous serum protein extravasation during harmaline tremors or kainic acid seizures in the rat: a comparison

1988 • 22 citations

Chloroquine treated rat: A possible model for alzheimer's disease

1995 • 10 citations