A Critical Role for the RelA Subunit of Nuclear Factor κB in Regulation of Multiple Immune-response Genes and in Fas-induced Cell Death

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

The Fas Death Factor

1995 • 4,070 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Innate Immunity: The Virtues of a Nonclonal System of Recognition

1997 • 2,397 citations

Human Chemokines: An Update

1997 • 2,235 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Lethal effect of the anti-Fas antibody in mice

1993 • 1,915 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Innate immunity: impact on the adaptive immune response

1997 • 1,542 citations

The product of the tobacco mosaic virus resistance gene N: Similarity to toll and the interleukin-1 receptor

1994 • 1,323 citations

NF-κB: A lesson in family values

1995 • 1,266 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Virus induction of human IFNβ gene expression requires the assembly of an enhanceosome

1995 • 994 citations

The DNA binding subunit of NF-κB is identical to factor KBF1 and homologous to the rel oncogene product

1990 • 900 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

The Role of Fas in Autoimmune Diabetes

1997 • 503 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

Dif, a dorsal-related gene that mediates an immune response in Drosophila

1993 • 464 citations

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

1997 • 453 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter.

1988 • 308 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

1997 • 296 citations

Functional characterization of the rat chemokine KC and its importance in neutrophil recruitment in a rat model of pulmonary inflammation.

1995 • 240 citations

Regulation of MHC gene expression

1993 • 215 citations

Fas- and FasL-deficient mice are resistant to induction of autoimmune encephalomyelitis.

1997 • 204 citations

Cell Death Mediators in Autoimmune Diabetes—No Shortage of Suspects

1997 • 177 citations

Structure of the human APO‐1 gene

1994 • 165 citations

Cloning, expression, and functional characterization of rat MIP-2: a neutrophil chemoattractant and epithelial cell mitogen

1995 • 152 citations

A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes.

1990 • 144 citations

Functional Role of CD40 and Its Ligand

1997 • 123 citations

The Rel subunit of NF-kappaB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations.

1996 • 120 citations

A Large Protein Containing Zinc Finger Domains Binds to Related Sequence Elements in the Enhancers of the Class I Major Histocompatibility Complex and Kappa Immunoglobulin Genes

1990 • 52 citations

Molecular genetics of Drosophila immunity

1994 • 44 citations