MAPK Mediates RAS-induced Chromosome Instability

Antibodies, a laboratory manual

1989 • 12,929 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Antibodies: A laboratory manual

1989 • 4,532 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Current Protocols in Cytometry

2001 • 916 citations

Abnormal Centrosome Amplification in the Absence of p53

1996 • 802 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

Raf meets Ras: completing the framework of a signal transduction pathway

1994 • 591 citations

Ras signalling and apoptosis

1998 • 559 citations

Ras-Dependent Induction of Cellular Responses by Constitutively Active Phosphatidylinositol-3 Kinase

1995 • 553 citations

Serum-, TPA-, and Ras-induced expression from Ap-1/Ets-driven promoters requires Raf-1 kinase.

1992 • 453 citations

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

1997 • 422 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway

1995 • 411 citations

The spindle checkpoint

1999 • 408 citations

A MAP kinase-dependent spindle assembly checkpoint in Xenopus egg extracts

1994 • 402 citations

Stimulation of Membrane Ruffling and MAP Kinase Activation by Distinct Effectors of RAS

1996 • 377 citations

Cell cycle tyrosine phosphorylation of p34cdc2 and a microtubule-associated protein kinase homolog in Xenopus oocytes and eggs.

1991 • 352 citations

Kinetochore chemistry is sensitive to tension and may link mitotic forces to a cell cycle checkpoint.

1995 • 344 citations

Sequential protein kinase reactions controlling cell growth and differentiation

1994 • 342 citations

Ras-dependent growth factor regulation of MEK kinase in PC12 cells

1994 • 322 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

Ras Transformation Results in an Elevated Level of Cyclin D1 and Acceleration of G₁ Progression in NIH 3T3 cells

1995 • 276 citations

Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway

1997 • 268 citations

Induction of metaphase arrest in cleaving Xenopus embryos by MAP kinase

1993 • 264 citations

What does mos do in oocytes and somatic cells?

1997 • 250 citations

Requirement for Src Family Protein Tyrosine Kinases in G ₂ for Fibroblast Cell Division

1995 • 249 citations

Activation of the MKK/ERK Pathway during Somatic Cell Mitosis: Direct Interactions of Active ERK with Kinetochores and Regulation of the Mitotic 3F3/2 Phosphoantigen

1998 • 223 citations

The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.

1994 • 216 citations

Active MAP Kinase in Mitosis: Localization at Kinetochores and Association with the Motor Protein CENP-E

1998 • 215 citations

Emerging concepts in the Ras superfamily of GTP‐binding proteins

1993 • 208 citations

Requirement for the MAP kinase kinase/MAP kinase cascade in Xenopus oocyte maturation.

1994 • 207 citations

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts.

1991 • 202 citations

BAD Enables Ceramide to Signal Apoptosis via Ras and Raf-1

1998 • 186 citations

Immunofluorescent staining of kinetochores in micronuclei: A new assay for the detection of aneuploidy

1988 • 179 citations

Initiation of Xenopus Oocyte Maturation by Activation of the Mitogen-activated Protein Kinase Cascade

1995 • 172 citations

Kinetochore detection in micronuclei: an alternative method for measuring chromosome loss

1989 • 172 citations

Induction of Xenopus Oocyte Meiotic Maturation by MAP Kinase

1995 • 154 citations

Hypoxic activation of nuclear factor-kappa B is mediated by a Ras and Raf signaling pathway and does not involve MAP kinase (ERK1 or ERK2).

1994 • 151 citations

Molecular dissection of mammalian gene amplification: New mechanistic insights revealed by analyses of very early events

1992 • 146 citations

The identification of micronucleated chromosomes: a possible assay for aneuploidy

1988 • 136 citations

Tyrosine phosphorylation of p34cdc2 and p42 during meiotic maturation of Xenopus oocyte: Antagonistic action of okadaic acid and 6-DMAP

1991 • 128 citations

Microinjection of mitotic cells with the 3F3/2 anti-phosphoepitope antibody delays the onset of anaphase.

1995 • 127 citations

Synergy between the Mos/Mitogen-Activated Protein Kinase Pathway and Loss of p53 Function in Transformation and Chromosome Instability

1997 • 119 citations

KINETOCHORES AND THE CHECKPOINT MECHANISM THAT MONITORS FOR DEFECTS IN THE CHROMOSOME SEGREGATION MACHINERY

1998 • 113 citations

Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation

1999 • 108 citations

Classification of micronuclei in murine erythrocytes: immunofluorescent staining using CREST antibodies compared to in situ hybridization with biotinylated gamma satellite DNA

1991 • 106 citations

A Role for Mitogen-activated Protein Kinase in the Spindle Assembly Checkpoint in XTC Cells

1997 • 100 citations

p120 GAP Modulates Ras Activation of Jun Kinases and Transformation

1997 • 97 citations

De novo formation of several features of a centromere following introduction of a Y alphoid YAC into mammalian cells

1994 • 95 citations

Kinetochore immunofluorescence in micronuclei: A rapid method for the in situ detection of aneuploidy and chromosome breakage in human fibroblasts

1988 • 91 citations

Differences between normal and ras-transformed NIH-3T3 cells in expression of the 170kD and 180kD forms of topoisomerase II.

1990 • 91 citations

Requirement for MAPK Activation for Normal Mitotic Progression in Xenopus Egg Extracts

1998 • 90 citations

Mitogen-activated protein kinase kinase is required for the mos-induced metaphase arrest.

1994 • 83 citations

An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer.

1995 • 79 citations

Ras signaling in tumor necrosis factor-induced apoptosis.

1996 • 77 citations

The protein kinase mos activates MAP kinase kinase in vitro and stimulates the MAP kinase pathway in mammalian somatic cells in vivo

1993 • 76 citations

Application of antikinetochore antibody staining (CREST staining) to micronuclei in erythrocytes induced in vivo

1990 • 70 citations

Kinetochore identification in micronuclei in mouse bone-marrow erythrocytes: An assay for the detection of aneuploidy-inducing agents

1990 • 64 citations

Differential Regulation of Discrete Apoptotic Pathways by Ras

1998 • 63 citations

Chapter 9 Measurement of Micronuclei by Flow Cytometry

1994 • 63 citations

Differentiation of micronuclei in mouse bone marrow cells: a comparison between CREST staining and fluorescent in situ hybridization with centromeric and telomeric DNA probes

1994 • 58 citations

Genetic instability and the acquisition of metastatic ability by rat mammary cancer cells following v-H-ras oncogene transfection.

1990 • 56 citations

Control of Ha-ras-mediated mammalian cell transformation by Escherichia coli regulatory elements.

1992 • 51 citations

Analysis of micronuclei induced by 2-chlorobenzylidene malonitrile (CS) using fluorescence in situ hybridization with telomeric and centromeric DNA probes, and flow cytometry

1993 • 48 citations

Casein Kinase II Catalyzes a Mitotic Phosphorylation on Threonine 1342 of Human DNA Topoisomerase IIα, Which Is Recognized by the 3F3/2 Phosphoepitope Antibody

1998 • 46 citations

Selective activation of oncogenic Ha-ras-induced apoptosis in NIH/3T3 cells

1998 • 45 citations

Mitotic and post mitotic consequences of genomic instability induced by oncogenic Ha-Ras

1995 • 45 citations

Differential occurrence of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblasts.

1992 • 32 citations

Mos overexpression in Swiss 3T3 cells induces meiotic-like alterations of the mitotic spindle.

1995 • 31 citations

High expression of ras p21 correlates with increased rate of abnormal mitosis in NIH3T3 cells.

1990 • 29 citations

Increased methotrexate resistance and dhfr gene amplification as a consequence of induced Ha-ras expression in NIH 3T3 cells.

1994 • 29 citations

H‐ras expression, genetic instability, and acquisition of metastatic ability by rat prostatic cancer cells following v‐H‐ras oncogene transfection

1991 • 27 citations

Involvement of fos in spontaneous and ultraviolet light‐induced genetic changes

1991 • 23 citations

Transfected c-Ha-ras oncogene enhances karyotypic instability and integrates predominantly in aberrant chromosomes

1993 • 21 citations

Expression ofRap 1 suppresses genomic instability ofH-ras transformed mouse fibroblasts

1997 • 15 citations

Cytogenetic findings in 111 ovarian cancer patients: Therapy-related chromosome aberrations and heterochromatic variants

1993 • 14 citations