Expression of the c-kit (CD117) Molecule in Normal and Malignant Hematopoiesis

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.

1988 • 727 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Embryonic expression of a haematopoietic growth factor encoded by the SI locus and the ligand for c-kit

1990 • 521 citations

Gonadal expression of c-kit encoded at the W locus of the mouse

1990 • 479 citations

Recombinant human stem cell factor synergises with GM-CSF, G-CSF, IL-3 and epo to stimulate human progenitor cells of the myeloid and erythroid lineages.

1991 • 454 citations

Developmental expression of c-kit, a proto-oncogene encoded by the W locus

1990 • 349 citations

Recombinant human stem cell factor enhances the formation of colonies by CD34+ and CD34+lin- cells, and the generation of colony-forming cell progeny from CD34+lin- cells cultured with interleukin-3, granulocyte colony-stimulating factor, or granulocyte-macrophage colony-stimulating factor

1991 • 341 citations

Involvement of the c-kit receptor in the adhesion of hematopoietic stem cells to stromal cells.

1994 • 253 citations

Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.

1993 • 233 citations

Mast cell typing: demonstration of a distinct hematopoietic cell type and evidence for immunophenotypic relationship to mononuclear phagocytes

1989 • 210 citations

Effect of murine mast cell growth factor (c-kit proto-oncogene ligand) on colony formation by human marrow hematopoietic progenitor cells

1991 • 202 citations

Model study detecting breast cancer cells in peripheral blood mononuclear cells at frequencies as low as 10(-7).

1995 • 201 citations

Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow

1991 • 195 citations

Isolation of c-kit receptor-expressing cells from bone marrow, peripheral blood, and fetal liver: functional properties and composite antigenic profile

1991 • 188 citations

Monoclonal antibody YB5.B8 identifies the human c-kit protein product

1991 • 160 citations

Coexpression of the c-kit receptor and the stem cell factor in gynecological tumors.

1994 • 153 citations

The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2.

1994 • 151 citations

Expression of the c-kit Proto-Oncogene and Its Ligand Stem Cell Factor (SCF) in Normal and Malignant Human Testicular Tissue

1995 • 149 citations

Mast cell growth factor (c-kit ligand) supports the growth of human multipotential progenitor cells with a high replating potential

1991 • 144 citations

Expression of a functional c-kit receptor on a subset of natural killer cells.

1993 • 143 citations

Effects of the stem cell factor, c-kit ligand, on human megakaryocytic cells

1992 • 140 citations

Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division

1995 • 140 citations

Human primitive hematopoietic progenitor cells are more enriched in KITlow cells than in KIThigh cells

1993 • 138 citations

Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group

1994 • 135 citations

Recombinant human stem cell factor, a c-kit ligand, stimulates hematopoiesis in primates

1991 • 133 citations

Role of bone marrow matrix in normal and abnormal hematopoiesis

1994 • 126 citations

Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group

1994 • 121 citations

Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts

1992 • 115 citations

Further Characterization of Surface Membrane Structures Expressed on Human Basophils and Mast Cells

1990 • 111 citations

Detection of rare cells at a frequency of one per million by flow cytometry

1993 • 108 citations

The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hemopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic leukemic cells.

1991 • 98 citations

Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in dorsal root ganglia of mouse embryos

1993 • 96 citations

Expression of the CD117 antigen (C‐Kit) on normal and myelomatous plasma cells

1996 • 91 citations

Flow cytometric analysis of mast cells from normal and pathological human bone marrow samples: identification and enumeration.

1996 • 89 citations

Characterization of aberrant phenotypes in acute myeloblastic leukemia

1995 • 87 citations

Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand

1992 • 86 citations

AML: immunophenotypic heterogeneity and prognostic significance of c-kit expression.

1994 • 82 citations

In vivo administration of recombinant methionyl human stem cell factor expands the number of human marrow hematopoietic stem cells

1993 • 76 citations

Sequential immunophenotypic analysis of mast cells in a case of systemic mast cell disease evolving to a mast cell leukemia

1997 • 74 citations

c-kit Gene was not transcribed in cultured mast cells of mast cell- deficient Wsh/Wsh mice that have a normal number of erythrocytes and a normal c-kit coding region

1992 • 73 citations

CD117/CD34 Expression in Leukemic Blasts

1996 • 72 citations

Interaction of human bone marrow fibroblasts with megakaryocytes: role of the c-kit ligand

1992 • 70 citations

A murine monoclonal antibody specific for a cell-surface antigen expressed by a subgroup of human myeloid leukaemias

1985 • 68 citations

Expression of a 150-kD cell surface antigen identified by monoclonal antibody YB5.B8 is associated with poor prognosis in acute non-lymphoblastic leukaemia

1988 • 64 citations

Flow cytometry: its applications in hematology.

1995 • 60 citations

The in vitro and in vivo effects of stem cell factor on human hematopoiesis

1996 • 54 citations

Detection and isolation of rare cells

1995 • 52 citations

Expression of c-<i>kit</i> and <i>kit</i> Ligand in Human Colon Carcinoma Cells

1993 • 52 citations

Interactions Between c-kit and Stem Cell Factor Are Not Required for B-Cell Development In Vivo

1997 • 50 citations

Expression and functional role of c‐kit ligand (SCF) in human multiple myeloma cells

1994 • 50 citations

Characterization of hemopoietic cell populations from human cord blood expressing c-kit.

1993 • 47 citations

Expression of the c-kit receptor in hypomelanosis: a comparative study between piebaldism, naevus depigmentosus and vitiligo

2006 • 45 citations

Changes in c‐Kit expression and effects of SCF during differentiation of human erythroid progenitor cells

1995 • 44 citations

Immunophenotype of c‐kit cells in normal human bone marrow: implications for the detection of minimal residual disease in AML

1995 • 44 citations

c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13.

1992 • 42 citations

Expression of lymphoid‐associated antigens in mast cells: report of a case of systemic mast cell disease

1995 • 42 citations

c-kit expression in human megakaryoblastic leukemia cell lines

1994 • 40 citations

Separation of myeloid and erythroid progenitors based on expression of CD34 and c-kit

1995 • 39 citations

Expression of the receptor tyrosine kinasec-kit in oligodendrocyte progenitor cells

1993 • 36 citations

Flow cytometry in the diagnosis of cancer

1995 • 35 citations

C-kit receptor (CD0117) expression in acute leukemia

1996 • 33 citations

A monoclonal antibody to a human mast cell/ myeloid leukaemia-specific antigen binds to normal haemopoietic progenitor cells and inhibits colony formation in vitro

1988 • 32 citations

Stem cell factor enhances in vivo effects of granulocyte colony stimulating factor for stimulating mobilization of peripheral blood progenitor cells

1996 • 31 citations

Biological characteristics of CD7(+) acute leukemia.

1996 • 31 citations

Expression of c-kit Receptor (CD 117) and CD34 in Leukemic Cells

1995 • 30 citations

Expression of c-kit mRNA and protein during the differentiation of human hematopoietic progenitor cells.

1993 • 30 citations

The c-kit proto-oncogene receptor is expressed on a subset of human CD3-CD4-CD8- (triple-negative) thymocytes.

1994 • 28 citations

The c‐kitproto‐oncogene in normal and malignant human hematopoiesis

1992 • 26 citations

The role of stem cell factor in mobilization of peripheral blood progenitor cells: Synergy with G‐CSF

1993 • 21 citations

The c-kit Molecule and the Surface Immunophenotype of Human Acute Leukemia

1994 • 20 citations

Effects of recombinant human Steel factor (c-kit ligand) on early cord blood hematopoietic precursors.

1994 • 20 citations

Expression of the c-kit mRNA in human aortic endothelial cells.

1994 • 18 citations

Cytofluorimetric and Functional Analysis of C-Kit Receptor in Acute Leukemia

1995 • 16 citations

Establishment in culture and characterization of a strain with mast cell and monocytic properties from the bone marrow of a child with diffuse cutaneous mastocytosis

1991 • 13 citations

Natural Killer Cell Acute Leukemia With Myeloid Antigen Expression:A Previously Undescribed Form of Acute Leukemia

1995 • 10 citations

Types of Neurons that Express mRNA of c-kit and its Ligand in Developing Murine Cerebellum.

1993 • 10 citations

Regulation of Mast Cell Proliferation, Maturation and Function by Stem Cell Factor, a Ligand for the c-<i>kit</i> Receptor

1992 • 9 citations

Analysis of c-kit expression of human erythroleukemia cell line, HEL: Clonal variation and relationship with erythroid and megakaryocytic phenotype

1995 • 7 citations

[Post-transfusion purpura. Description of 2 cases diagnosed at the same hospital in a 6-month period].

1996 • 1 citations