Neuronal Cyclin-Dependent Kinase 5 Activity Is Critical for Survival

A family of human cdc2-related protein kinases.

1992 • 928 citations

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1994 • 915 citations

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 • 901 citations

Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 • 727 citations

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 • 592 citations

A brain-specific activator of cyclin-dependent kinase 5

1994 • 575 citations

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

1999 • 557 citations

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

1992 • 507 citations

Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5

1993 • 470 citations

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system

1993 • 453 citations

Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25

2000 • 378 citations

Cables Links Cdk5 and c-Abl and Facilitates Cdk5 Tyrosine Phosphorylation, Kinase Upregulation, and Neurite Outgrowth

2000 • 378 citations

Neurotrophins Induce Formation of Functional Excitatory and Inhibitory Synapses between Cultured Hippocampal Neurons

1998 • 365 citations

An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator

1995 • 342 citations

Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex

1998 • 315 citations

Neurofilaments in Health and Disease

1998 • 282 citations

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression.

1992 • 275 citations

A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubule

1993 • 235 citations

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.

1992 • 230 citations

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

1993 • 207 citations

Evidence for the Participation of the Neuron-Specific CDK5 Activator P35 during Laminin-Enhanced Axonal Growth

1998 • 193 citations

Regulation of N-cadherin-mediated adhesion by the p35–Cdk5 kinase

2000 • 177 citations

A novel disruption of cortical development inp35?/? mice distinct fromreeler

1998 • 158 citations

Region-specific expression of cyclin-dependent kinase 5 (cdk5) and its activators, p35 and p39, in the developing and adult rat central nervous system

1998 • 143 citations

Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons

1997 • 131 citations

The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning.

1997 • 118 citations

Regulation of cyclin-dependent kinase 5 catalytic activity by phosphorylation

1999 • 113 citations

Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells

1997 • 112 citations

The cyclin-dependent kinase Cdk5 controls multiple aspects of axon patterning in vivo

2000 • 84 citations

Temporal and spatial patterns of expression of p35, a regulatory subunit of cyclin-dependent kinase 5, in the nervous system of the mouse.

1997 • 79 citations

Molecular Characterization of a Neuronal‐Specific Protein that Stimulates the Activity of Cdk5

1995 • 78 citations

Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)

1997 • 68 citations

Brain-derived neurotrophic factor-induced phosphorylation of neurofilament-H subunit in primary cultures of embryo rat cortical neurons

2000 • 58 citations

Ser ⁶⁷ -phosphorylated inhibitor 1 is a potent protein phosphatase 1 inhibitor

2000 • 55 citations

Cyclin-dependent Kinase 5 in Lewy Body-like Inclusions in Anterior Horn Cells of a Patient with Sporadic Amyotrophic Lateral Sclerosis

1997 • 54 citations

Changes in the expression of novel Cdk5 activator messenger RNA (p39nck5ai mRNA) during rat brain development

1997 • 53 citations

Localization and developmental changes in the neuron-specific cyclin-dependent kinase 5 activator (p35nck5a) in the rat brain

1996 • 53 citations

Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS

1999 • 52 citations

Molecular Cloning and Chromosomal Mapping of the Mouse Gene Encoding Cyclin-Dependent Kinase 5 Regulatory Subunit p35

1996 • 39 citations

In situ hybridization-theory and practice.

1999 • 39 citations

Inhibition of neuronal cyclin-dependent kinase-5 by staurosporine and purine analogs is independent of activation by munc-18

1996 • 30 citations

Spatial and temporal activity of the dentin sialophosphoprotein gene promoter: differential regulation in odontoblasts and ameloblasts.

1999 • 30 citations

In situ hybridization—Theory and practice

1999 • 30 citations

Molecular Cloning and Chromosomal Mapping of the Mouse Cyclin-Dependent Kinase 5 Gene

1995 • 29 citations

Immunohistochemical localization of CDK5 activator p39 in the rat brain

1999 • 23 citations

Distinct cellular compartment of cyclin-dependent kinase 5 (Cdk5) and neuron-specific Cdk5 activator protein (p35nck5a) in the developing rat cerebellum

1996 • 22 citations