The role of E-cadherin and scatter factor in tumor invasion and cell motility

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Molecular cloning and expression of human hepatocyte growth factor

1989 • 2,191 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

The cadherins: cell-cell adhesion molecules controlling animal morphogenesis

1988 • 1,626 citations

E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.

1991 • 1,592 citations

The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.

1989 • 1,393 citations

Scatter factor is a fibroblast-derived modulator of epithelial cell mobility

1987 • 1,333 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

1989 • 1,214 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion.

1989 • 961 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Tumor diagnosis by intermediate filament typing: a novel tool for surgical pathology.

1983 • 863 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.

1990 • 753 citations

Transformation of cell adhesion properties by exogenously introduced E-cadherin cDNA

1987 • 752 citations

Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells.

1990 • 695 citations

BIOCHEMICAL INTERACTIONS OF TUMOR CELLS WITH THE BASEMENT MEMBRANE

1986 • 693 citations

Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor

1989 • 664 citations

Evidence for the identity of human scatter factor and human hepatocyte growth factor.

1991 • 651 citations

Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma

1987 • 638 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas.

1989 • 598 citations

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

1990 • 577 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

1985 • 429 citations

Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue

1983 • 396 citations

Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

1987 • 396 citations

Cloning and expression of cDNA encoding a neural calcium-dependent cell adhesion molecule: its identity in the cadherin gene family.

1988 • 382 citations

Human breast carcinoma cells in continuous culture: a review.

1978 • 345 citations

Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma.

1988 • 343 citations

Cell-cell interactions in early embryogenesis: A molecular approach to the role of calcium

1981 • 338 citations

The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of Ca2+-dependent cell adhesion.

1987 • 304 citations

Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules.

1988 • 301 citations

Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.

1990 • 292 citations

Characterization of L-CAM, a major cell adhesion molecule from embryonic liver cells

1983 • 289 citations

Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin.

1985 • 286 citations

The calcium-dependent cell-cell adhesion system regulates inner cell mass formation and cell surface polarization in early mouse development

1983 • 242 citations

The Structure and Function of Intercellular Junctions in Cancer

1976 • 240 citations

Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues

1984 • 206 citations

Early epochal maps of two different cell adhesion molecules.

1983 • 204 citations

Uvomorulin: a nonintegral membrane protein of early mouse embryo.

1983 • 186 citations

Tumor dedifferentiation: An important step in tumor invasion

1985 • 181 citations

Desmosomal proteins: new markers for identification and classification of tumors.

1986 • 174 citations

Evidence for the identy of human scatter factor and human hepatocyte growth factor.

1991 • 163 citations

Sequence analysis of a cDNA clone encoding the liver cell adhesion molecule, L-CAM.

1987 • 163 citations

Unstable Expression of E‐Cadherin Adhesion Molecules in Metastatic Ovarian Tumor Cells

1989 • 157 citations

Cell-cell interaction and polarity of epithelial cells: Specific perturbation using a monoclonal antibody

1983 • 153 citations

Purification of the migration stimulating factor produced by fetal and breast cancer patient fibroblasts.

1989 • 153 citations

Molecular cloning of a human Ca2+-dependent cell-cell adhesion molecule homologous to mouse placental cadherin: its low expression in human placental tissues.

1989 • 120 citations

A cell surface molecule involved in aggregation of embryonic liver cells.

1980 • 104 citations

Protein factors which regulate cell motility

1989 • 100 citations

Regional assignment of the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16

1989 • 93 citations

Structure of the gene for the liver cell adhesion molecule, L-CAM.

1988 • 52 citations

[Epithelial tumor markers].

1986 • 17 citations

Kolonkarzinom: Präoperatives CEA, Tumordifferenzierung und Prognose

2008 • 8 citations

Deleted Work

1955 • 0 citations