The insulin-like growth factor binding proteins (IGFBPs) in human breast cancer

Growth Factors and Cancer

1991 • 2,044 citations

An insulin-like growth factor (IGF) binding protein enhances the biologic response to IGF-I.

1987 • 682 citations

Estrogenic Regulation of Growth and Polypeptide Growth Factor Secretion in Human Breast Carcinoma

1987 • 576 citations

Binding proteins for the insulin-like growth factors: Structure, regulation and function

1989 • 565 citations

Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts

1988 • 488 citations

Analysis of Insulin-Like Growth Factor I Gene Expression in Malignancy: Evidence for a Paracrine Role in Human Breast Cancer

1989 • 403 citations

Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells.

1990 • 385 citations

Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein

1988 • 367 citations

Insulin-Like Growth Factor (IGF) Binding Protein from Human Decidua Inhibits the Binding and Biological Action of IGF-I in Cultured Choriocarcinoma Cells**

1988 • 347 citations

Insulin-Like Growth Factor I (IGF-I)-Binding Protein Complex Is a Better Mitogen than Free IGF-I*

1989 • 318 citations

Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human

1991 • 313 citations

Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.

1986 • 310 citations

Phosphorylation of insulin-like growth factor (IGF)-binding protein 1 in cell culture and in vivo: effects on affinity for IGF-I.

1991 • 294 citations

Cloning, characterization, and expression of a human insulin-like growth factor binding protein

1988 • 249 citations

Insulin-Like Growth Factor-ll (IGF-II): A Potential Autocrine/Paracrine Growth Factor for Human Breast Cancer Acting via the IGF-I Receptor

1989 • 248 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2).

1989 • 240 citations

Molecular Cloning of the cDNAs Encoding a Novel Insulin-Like Growth Factor-Binding Protein from Rat and Human

1990 • 239 citations

Isolation and Molecular Cloning of Insulin-Like Growth Factor-Binding Protein-6

1991 • 233 citations

Insulin-Like Growth Factor (IGF) Binding Protein Complementary Deoxyribonucleic Acid from Human HEP G2 Hepatoma Cells: Predicted Protein Sequence Suggests an IGF Binding Domain Different from Those of the IGF-I and IGF-II Receptors

1988 • 232 citations

Inhibition of biological activity of multiplication-stimulating activity by binding to its carrier protein.

1980 • 212 citations

Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.

1991 • 204 citations

Inhibitory Insulin-Like Growth Factor-Binding Protein: Cloning, Complete Sequence, and Physiological Regulation

1990 • 204 citations

Multihormonal Regulation of the Progesterone Receptor in MCF-7 Human Breast Cancer Cells: Interrelationships among Insulin/Insulin-Like Growth Factor-I, Serum, and Estrogen*

1990 • 187 citations

Insulin-Like Growth Factor Binding Protein Secretion by Breast Carcinoma Cell Lines: Correlation with Estrogen Receptor Status*

1990 • 135 citations

Insulin-Like Growth Factor (IGF)-Binding Protein-3 Blocks IGF-I-Induced Receptor Down-Regulation and Cell Desensitization in Cultured Bovine Fibroblasts*

1991 • 130 citations

Insulin‐Like Growth Factor (IGF) Binding Proteins: the Role of Serum IGFBPs in Regulating IGF Availability

1991 • 126 citations

Insulin-like growth factor-II overexpression in MCF-7 cells induces phenotypic changes associated with malignant progression.

1992 • 120 citations

Retinoid Modulation of Insulin-Like Growth Factor-Binding Proteins and Inhibition of Breast Carcinoma Proliferation*

1991 • 110 citations

Demonstration of insulin-like growth factor (IGF-I and -II) receptors and binding protein in human breast cancer cell lines

1988 • 110 citations

Regulation of Insulin-Like Growth Factor-Binding Protein (IGFBP) Expression by Breast Cancer Cells: Use of IGFBP-1 as as Inhibitor of Insulin-like Growth Factor Action

1992 • 107 citations

Insulin-Like Growth Factor (IGF) Binding to Cell Monolayers Is Directly Modulated by the Addition of IGF-Binding Proteins*

1991 • 102 citations

Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein.

1991 • 90 citations

Mechanism of action of retinoids

1986 • 86 citations

Effect of 4-Hydroxyphenylretinamide and Retinoic Acid on Proliferation and Cell Cycle of Cultured Human Breast Cancer Cells

1985 • 82 citations

Identification of insulin-like growth factor binding proteins in breast cancer cells

1991 • 75 citations

Growth inhibition by retinol of a human breast carcinoma cell line in vitro and in athymic mice.

1984 • 72 citations

Characterization of Insulin-Like Growth Factor Binding Proteins from Human Breast Cancer Cells

1989 • 70 citations

A factor contained in plasma is required for IGF binding protein‐1 to potentiate the effect of IGF‐I on smooth muscle cell DNA synthesis

1990 • 63 citations

The insulin-like growth factor binding protein BP-25 is expressed by human breast cancer cells

1989 • 61 citations

Insulin‐Like growth factor binding protein (IGFBP) inhibits igf action on human osteosarcoma cells

1991 • 61 citations

Secretion and biological actions of insulin‐like growth factor binding proteins in two human tumor‐derived cell lines in vitro

1991 • 59 citations

Autocrine production of insulin-like growth factor II using an inducible expression system results in reduced estrogen sensitivity of MCF-7 human breast cancer cells.

1991 • 57 citations

IGFBP-1, an insulin like growth factor binding protein, is a cell growth inhibitor

1991 • 56 citations

Role of estrogen-induced insulin-like growth factors in the proliferation of human breast cancer cells.

1990 • 54 citations

Insulin-like growth factor-binding protein-1 inhibits binding of IGF-I on fetal skin fibroblasts but stimulates their DNA synthesis

1990 • 52 citations

Partial characterization of somatomedin C-like immunoreactivity secreted by breast cancer cells in vitro

1987 • 41 citations

Identification of a Specific Inhibitor of Nonsuppressible Insulin-Like Activity in a Partially Purified Human Serum Fraction*

1981 • 37 citations

Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture

1990 • 33 citations

Identification and regulation of insulin-like growth factor binding proteins produced by hormone-dependent and -independent human breast cancer cell lines

1991 • 23 citations

Characterization and hormonal regulation of radioimmunoassayable IGF-I (insulin-like growth factor I) like activity and IGF-binding proteins secreted by human breast cancer cells.

1990 • 13 citations